Cyclin C is a haploinsufficient tumour suppressor.

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Published in Nat Cell Biol on October 26, 2014

Authors

Na Li1, Anne Fassl1, Joel Chick2, Hiroyuki Inuzuka3, Xiaoyu Li4, Marc R Mansour5, Lijun Liu1, Haizhen Wang1, Bryan King6, Shavali Shaik3, Alejandro Gutierrez7, Alban Ordureau2, Tobias Otto1, Taras Kreslavsky4, Lukas Baitsch8, Leah Bury1, Clifford A Meyer9, Nan Ke1, Kristin A Mulry1, Michael J Kluk10, Moni Roy10, Sunkyu Kim11, Xiaowu Zhang12, Yan Geng1, Agnieszka Zagozdzon1, Sarah Jenkinson13, Rosemary E Gale13, David C Linch13, Jean J Zhao8, Charles G Mullighan14, J Wade Harper2, Jon C Aster10, Iannis Aifantis6, Harald von Boehmer4, Steven P Gygi2, Wenyi Wei3, A Thomas Look7, Piotr Sicinski1

Author Affiliations

1: 1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
2: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
3: Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA.
4: 1] Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts 02115, USA.
5: 1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA [4] Department of Haematology, University College London Cancer Institute, London WC1E 6BT, UK.
6: Howard Hughes Medical Institute and Department of Pathology, NYU School of Medicine, New York, New York 10016, USA.
7: 1] Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Division of Hematology/Oncology, Children's Hospital, Boston, Massachusetts 02115, USA [3] Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.
8: 1] Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA.
9: 1] Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Harvard School of Public Health, Boston, Massachusetts 02115, USA.
10: Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
11: Novartis Institutes for BioMedical Research, Cambridge, Massachusetts 02139, USA.
12: Cell Signaling Technology, Inc., Danvers, Massachusetts 01923, USA.
13: Department of Haematology, University College London Cancer Institute, London WC1E 6BT, UK.
14: Department of Pathology, St. Jude Research Hospital, Memphis, Tennessee 38105, USA.

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