CD8 and CD4 epitope predictions in RV144: no strong evidence of a T-cell driven sieve effect in HIV-1 breakthrough sequences from trial participants.

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Published in PLoS One on October 28, 2014

Authors

Kalpana Dommaraju1, Gustavo Kijak1, Jonathan M Carlson2, Brendan B Larsen3, Sodsai Tovanabutra1, Dan E Geraghty4, Wenjie Deng3, Brandon S Maust3, Paul T Edlefsen4, Eric Sanders-Buell1, Silvia Ratto-Kim1, Mark S deSouza5, Supachai Rerks-Ngarm6, Sorachai Nitayaphan7, Punnee Pitisuttihum8, Jaranit Kaewkungwal8, Robert J O'Connell5, Merlin L Robb1, Nelson L Michael9, James I Mullins3, Jerome H Kim9, Morgane Rolland1

Author Affiliations

1: US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America; Henry Jackson Foundation, Bethesda, Maryland, United States of America.
2: Microsoft Research, Los Angeles, California, United States of America.
3: Department of Microbiology, University of Washington, Seattle, Washington, United States of America.
4: Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America.
5: Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
6: Thai Ministry of Public Health, Nonthaburi, Thailand.
7: Royal Thai Army Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
8: Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand.
9: US Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America.

Associated clinical trials:

HIV Vaccine Trial in Thai Adults | NCT00223080

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