Hypoxia promotes stem cell phenotypes and poor prognosis through epigenetic regulation of DICER.

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Published in Nat Commun on October 29, 2014

Authors

Twan van den Beucken1,2,3, Elizabeth Koch1,4, Kenneth Chu5, Rajesha Rupaimoole6, Peggy Prickaerts7, Michiel Adriaens8,9, Jan Willem Voncken7, Adrian L Harris10, Francesca M Buffa10, Syed Haider5, Maud H W Starmans2,5, Cindy Q Yao4,5, Mircea Ivan11, Cristina Ivan12, Chad V Pecot13, Paul C Boutros4,5,14, Anil K Sood6,12, Marianne Koritzinsky1,15,16, Bradly G Wouters1,2,4,16,17

Author Affiliations

1: Princess Margaret Cancer Centre and Campbell Family Institute for Cancer Research, University Health Network, Toronto, ON M5G 2M9, Canada.
2: Department of Radiation Oncology, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands.
3: Department of Toxicogenomics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands.
4: Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 1L7, Canada.
5: Informatics and Bio-computing Program, Ontario Institute for Cancer Research, Toronto, ON M5G 1L7, Canada.
6: Department of Gynecologic Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
7: Department of Molecular Genetics, GROW School for Oncology and Developmental Biology, Maastricht University Medical Center, 6200 MD, Maastricht, The Netherlands.
8: Department of Experimental Cardiology, Heart Failure Research Centre, Academic Medical Center, Amsterdam, The Netherlands.
9: Department of Bioinformatics - BiGCaT, Maastricht University, Maastricht, The Netherlands.
10: Cancer Research UK Department of Oncology, The Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
11: Department of Medicine, The Indiana University Melvin and Bren Simon Cancer Center, Indianapolis 46202, USA.
12: Center for RNA Interference and Non-Coding RNAs. The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
13: Department of Thoracic, Head and Neck Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA.
14: Department of Pharmacology & Toxicology, University of Toronto, Toronto, ON M5S 1A8, Canada.
15: Institute of Medical Science, University of Toronto, ON M5S 1A8, Canada.
16: Department of Radiation Oncology, University of Toronto, Toronto, ON M5T 1P5, Canada.
17: Selective Therapies Program, Ontario Institute for Cancer Research, Toronto, ON M5G 1L7, Canada.

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