Published in Neoplasia on October 23, 2014
Markers of cellular senescence. Telomere shortening as a marker of cellular senescence. Aging (Albany NY) (2016) 0.88
Clinical Relevance of Telomere Status and Telomerase Activity in Colorectal Cancer. PLoS One (2016) 0.78
Relative telomere lengths in tumor and normal mucosa are related to disease progression and chromosome instability profiles in colorectal cancer. Oncotarget (2016) 0.77
A Randomized Controlled Trial to Increase Navy Bean or Rice Bran Consumption in Colorectal Cancer Survivors. Nutr Cancer (2016) 0.77
Aberrant reduction of telomere repetitive sequences in plasma cell-free DNA for early breast cancer detection. Oncotarget (2015) 0.76
Formation and stabilization of the telomeric antiparallel G-quadruplex and inhibition of telomerase by novel benzothioxanthene derivatives with anti-tumor activity. Sci Rep (2015) 0.75
A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res (1988) 77.80
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
Specific association of human telomerase activity with immortal cells and cancer. Science (1994) 28.20
Telomere measurement by quantitative PCR. Nucleic Acids Res (2002) 18.69
Creation of human tumour cells with defined genetic elements. Nature (1999) 16.47
CpG island methylator phenotype underlies sporadic microsatellite instability and is tightly associated with BRAF mutation in colorectal cancer. Nat Genet (2006) 13.63
A highly conserved repetitive DNA sequence, (TTAGGG)n, present at the telomeres of human chromosomes. Proc Natl Acad Sci U S A (1988) 11.81
Switching and signaling at the telomere. Cell (2001) 11.25
Telomere reduction in human colorectal carcinoma and with ageing. Nature (1990) 11.24
Absolute quantification of somatic DNA alterations in human cancer. Nat Biotechnol (2012) 10.87
TRF2 protects human telomeres from end-to-end fusions. Cell (1998) 10.13
The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell (1987) 8.32
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28
Telomere length measurement by a novel monochrome multiplex quantitative PCR method. Nucleic Acids Res (2009) 6.42
Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61
The age of cancer. Nature (2000) 4.32
Beginning to understand the end of the chromosome. Cell (2004) 3.46
Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science (2001) 3.35
Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res (1995) 3.16
Structure and polymorphism of human telomere-associated DNA. Cell (1990) 3.14
Telomere dysfunction provokes regional amplification and deletion in cancer genomes. Cancer Cell (2002) 3.06
Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet (1998) 3.01
Mammalian Ku86 protein prevents telomeric fusions independently of the length of TTAGGG repeats and the G-strand overhang. EMBO Rep (2000) 3.00
DNA double-strand break repair proteins are required to cap the ends of mammalian chromosomes. Proc Natl Acad Sci U S A (1999) 2.97
Telomere dysfunction and evolution of intestinal carcinoma in mice and humans. Nat Genet (2001) 2.92
Different telomere damage signaling pathways in human and mouse cells. EMBO J (2002) 2.87
Telomere dynamics in cancer progression and prevention: fundamental differences in human and mouse telomere biology. Nat Med (2000) 2.81
Telomere dysfunction increases mutation rate and genomic instability. Cell (2001) 2.62
Origin of human chromosome 2: an ancestral telomere-telomere fusion. Proc Natl Acad Sci U S A (1991) 2.54
Telomere dysfunction and fusion during the progression of chronic lymphocytic leukemia: evidence for a telomere crisis. Blood (2010) 2.16
Telomere shortening is associated with cell division in vitro and in vivo. Exp Cell Res (1995) 2.11
Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96
Does a sentinel or a subset of short telomeres determine replicative senescence? Mol Biol Cell (2004) 1.92
The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88
Differences in gene expression in prostate cancer, normal appearing prostate tissue adjacent to cancer and prostate tissue from cancer free organ donors. BMC Cancer (2005) 1.87
The telomere deprotection response is functionally distinct from the genomic DNA damage response. Mol Cell (2013) 1.81
Mechanisms of cellular senescence in human and mouse cells. Biogerontology (2004) 1.76
Telomerase reactivation following telomere dysfunction yields murine prostate tumors with bone metastases. Cell (2012) 1.75
Oncogene-induced telomere dysfunction enforces cellular senescence in human cancer precursor lesions. EMBO J (2012) 1.71
Nonradioactive detection of telomerase activity using the telomeric repeat amplification protocol. Nat Protoc (2006) 1.70
Telomere dysfunction and the initiation of genome instability. Nat Rev Cancer (2003) 1.69
Telomerase and telomere length in the development and progression of premalignant lesions to colorectal cancer. Clin Cancer Res (1997) 1.68
DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci U S A (2001) 1.64
A telomere-dependent DNA damage checkpoint induced by prolonged mitotic arrest. Nat Struct Mol Biol (2012) 1.59
Molecular genetics. Colorectal cancer genes. Nature (1990) 1.56
17p allelic losses in diploid cells of patients with Barrett's esophagus who develop aneuploidy. Cancer Res (1994) 1.52
Telomere dysfunction and chromosome instability. Mutat Res (2011) 1.51
Genetic anticipation is associated with telomere shortening in hereditary breast cancer. PLoS Genet (2011) 1.51
Stabilised p53 facilitates aneuploid clonal divergence in colorectal cancer. Oncogene (1993) 1.50
Importance of TRF1 for functional telomere structure. J Biol Chem (2003) 1.37
Telomeric structure in cells with chromosome end associations. Chromosoma (1993) 1.34
Epigenetic regulation of telomeres in human cancer. Oncogene (2008) 1.33
Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers. Br J Cancer (2010) 1.30
Telomere length in breast cancer patients before and after chemotherapy with or without stem cell transplantation. Br J Cancer (2001) 1.28
Telomerase activity in preneoplastic and neoplastic gastric and colorectal lesions. Clin Cancer Res (1995) 1.24
Telomere loss as a mechanism for chromosome instability in human cancer. Cancer Res (2010) 1.24
Fusion of short telomeres in human cells is characterized by extensive deletion and microhomology, and can result in complex rearrangements. Nucleic Acids Res (2009) 1.19
Mutations of APC, K-ras, and p53 are associated with specific chromosomal aberrations in colorectal adenocarcinomas. Cancer Res (2003) 1.14
Flow cytometric analysis of DNA aneuploidy in primary and metastatic human solid tumors. Cytometry (1984) 1.11
Telomere shortening of epithelial cells characterises the adenoma-carcinoma transition of human colorectal cancer. Gut (2003) 1.09
Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer. Eur J Cancer (2001) 1.06
The potential utility of telomere-related markers for cancer diagnosis. J Cell Mol Med (2011) 1.04
Acceleration of telomere loss by chemotherapy is greater in older patients with locally advanced head and neck cancer. Clin Cancer Res (2006) 1.02
DNA repair pathways involved in anaphase bridge formation. Genes Chromosomes Cancer (2007) 1.01
K-ras gene mutations in normal colorectal tissues from K-ras mutation-positive colorectal cancer patients. Cancer Res (1997) 0.99
Extensive telomere erosion in the initiation of colorectal adenomas and its association with chromosomal instability. J Natl Cancer Inst (2013) 0.98
Alterations of DNA and chromatin structures at telomeres and genetic instability in mouse cells defective in DNA polymerase alpha. Mol Cell Biol (2005) 0.97
Telomere fusions in early human breast carcinoma. Proc Natl Acad Sci U S A (2012) 0.97
Evidence for a putative telomerase repressor gene in the 3p14.2-p21.1 region. Genes Chromosomes Cancer (1998) 0.97
Transient telomere dysfunction induces chromosomal instability and promotes carcinogenesis. J Clin Invest (2012) 0.95
The effect of chemotherapy on telomere dynamics: clinical results and possible mechanisms. Leuk Lymphoma (2013) 0.93
Epigenetic alterations associated with cellular senescence: a barrier against tumorigenesis or a red carpet for cancer? Semin Cancer Biol (2011) 0.92
Telomere dynamics in mice and humans. Semin Hematol (2013) 0.92
Telomerase is active in normal gastrointestinal mucosa and not up-regulated in precancerous lesions. J Cancer Res Clin Oncol (1999) 0.90
Telomere length is a prognostic factor for overall survival in colorectal cancer. Colorectal Dis (2011) 0.87
Promoter methylation and expression changes of CDH1 and P16 genes in invasive breast cancer and adjacent normal breast tissue. Neoplasma (2010) 0.86
Telomerase activity and human telomerase reverse transcriptase expression in colorectal carcinoma. World J Gastroenterol (2006) 0.83
Tumor aneuploidy in young patients with colorectal cancer. Cancer (1993) 0.82
Detection of the DCC gene product in normal and malignant colorectal tissues and its relation to a codon 201 mutation. Br J Cancer (1998) 0.81
Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade. Breast Cancer Res Treat (2013) 0.80
Abnormal DNA ploidy and proliferative patterns in superficial colonic epithelium adjacent to colorectal cancer. Cancer (1990) 0.80
Telomerase expression of malignant epithelial cells correlates with Dukes' stage in colorectal cancer. Colorectal Dis (2002) 0.79
DNA content in human colon cancer and non-neoplastic adjacent mucosa. Int J Biol Markers (1995) 0.77