Published in J Alzheimers Dis on January 01, 2015
Dissecting Alzheimer disease in Down syndrome using mouse models. Front Behav Neurosci (2015) 0.79
Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis (2016) 0.76
Differentiation impairs Bach1 dependent HO-1 activation and increases sensitivity to oxidative stress in SH-SY5Y neuroblastoma cells. Sci Rep (2017) 0.75
Bilirubin is an antioxidant of possible physiological importance. Science (1987) 11.26
The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol (1997) 7.50
Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med (1997) 3.74
Mechanisms of cell protection by heme oxygenase-1. Annu Rev Pharmacol Toxicol (2010) 3.67
Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J (2002) 3.06
Signaling to heme oxygenase-1 and its anti-inflammatory therapeutic potential. Biochem Pharmacol (2010) 2.71
Oxidative damage in Alzheimer's. Nature (1996) 2.55
Heme mediates derepression of Maf recognition element through direct binding to transcription repressor Bach1. EMBO J (2001) 2.32
Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature (1996) 2.29
NAD(P)H:quinone acceptor oxidoreductase 1 (NQO1), a multifunctional antioxidant enzyme and exceptionally versatile cytoprotector. Arch Biochem Biophys (2010) 2.27
Bach1 competes with Nrf2 leading to negative regulation of the antioxidant response element (ARE)-mediated NAD(P)H:quinone oxidoreductase 1 gene expression and induction in response to antioxidants. J Biol Chem (2005) 2.14
Protein oxidation in the brain in Alzheimer's disease. Neuroscience (2001) 2.00
Localization of a retroviral element within the rd gene coding for the beta subunit of cGMP phosphodiesterase. Proc Natl Acad Sci U S A (1993) 1.95
Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem (1995) 1.84
Structure of human biliverdin IXbeta reductase, an early fetal bilirubin IXbeta producing enzyme. Nat Struct Biol (2001) 1.84
Antioxidant activities of bile pigments. Antioxid Redox Signal (2004) 1.65
Heme oxygenase and heme degradation. Biochem Biophys Res Commun (2005) 1.57
Biliverdin reductase-A: a novel drug target for atorvastatin in a dog pre-clinical model of Alzheimer disease. J Neurochem (2011) 1.53
Molecular genetic analysis of Down syndrome. Hum Genet (2009) 1.52
Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn. Mamm Genome (2011) 1.47
Potential role of conjugated bilirubin and copper in the metabolism of lipid peroxides in bile. Proc Natl Acad Sci U S A (1987) 1.43
Heme induces ubiquitination and degradation of the transcription factor Bach1. Mol Cell Biol (2007) 1.43
Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin. Trends Pharmacol Sci (2009) 1.38
Neurofibrillary tangles, granulovacuolar degeneration, and neuron loss in Down Syndrome: quantitative comparison with Alzheimer dementia. Ann Neurol (1980) 1.33
Down syndrome and genetics - a case of linked histories. Nat Rev Genet (2005) 1.31
New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda) (2005) 1.26
Early amyloid deposition in the medial temporal lobe of young Down syndrome patients: a regional quantitative analysis. Exp Neurol (1998) 1.24
Amyloid β-peptide (1-42)-induced oxidative stress in Alzheimer disease: importance in disease pathogenesis and progression. Antioxid Redox Signal (2013) 1.20
Nitrosative stress, cellular stress response, and thiol homeostasis in patients with Alzheimer's disease. Antioxid Redox Signal (2006) 1.20
Down syndrome and Alzheimer's disease: a link between development and aging. Ment Retard Dev Disabil Res Rev (2001) 1.20
Protein expression of BACE1, BACE2 and APP in Down syndrome brains. Amino Acids (2007) 1.16
The heme oxygenase system and its functions in the brain. Cell Mol Biol (Noisy-le-grand) (2000) 1.14
Redox regulation of the transcriptional repressor Bach1. Free Radic Biol Med (2005) 1.13
Free radicals: key to brain aging and heme oxygenase as a cellular response to oxidative stress. J Gerontol A Biol Sci Med Sci (2004) 1.09
Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic Biol Med (1998) 1.08
The heme oxygenase/biliverdin reductase pathway in drug research and development. Curr Drug Metab (2009) 1.03
Association between frontal cortex oxidative damage and beta-amyloid as a function of age in Down syndrome. Biochim Biophys Acta (2011) 1.02
Down's syndrome, aging, and Alzheimer's disease: a clinical review. Ann N Y Acad Sci (1982) 1.01
4-Hydroxy-2-nonenal, a reactive product of lipid peroxidation, and neurodegenerative diseases: a toxic combination illuminated by redox proteomics studies. Antioxid Redox Signal (2012) 1.01
Beta-amyloid, oxidative stress and down syndrome. Curr Alzheimer Res (2006) 0.99
Risk factors for dementia in people with down syndrome: issues in assessment and diagnosis. Am J Ment Retard (2004) 0.99
Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia. Curr Gerontol Geriatr Res (2011) 0.98
Oxidative stress occurs early in Down syndrome pregnancy: A redox proteomics analysis of amniotic fluid. Proteomics Clin Appl (2011) 0.98
Neurological phenotypes for Down syndrome across the life span. Prog Brain Res (2012) 0.98
Oxidative modification of brain proteins in Alzheimer's disease: perspective on future studies based on results of redox proteomics studies. J Alzheimers Dis (2013) 0.97
Heme oxygenase-1 posttranslational modifications in the brain of subjects with Alzheimer disease and mild cognitive impairment. Free Radic Biol Med (2012) 0.95
Characterization of the S-denitrosylating activity of bilirubin. J Cell Mol Med (2009) 0.94
Oxidative and nitrosative modifications of biliverdin reductase-A in the brain of subjects with Alzheimer's disease and amnestic mild cognitive impairment. J Alzheimers Dis (2011) 0.93
Oxidative stress and neural dysfunction in Down syndrome. J Neural Transm Suppl (1999) 0.92
Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part III). Amino Acids (2003) 0.91
Bach1, a heme-dependent transcription factor, reveals presence of multiple heme binding sites with distinct coordination structure. IUBMB Life (2007) 0.91
Quinone reductase (NQO1), a sensitive redox indicator, is increased in Alzheimer's disease. Redox Rep (1999) 0.91
Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: Challenging the gene dosage effect hypothesis (Part IV). Amino Acids (2003) 0.91
Biliverdin reductase--a protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment. Biochim Biophys Acta (2011) 0.90
Bilirubin and S-nitrosothiols interaction: evidence for a possible role of bilirubin as a scavenger of nitric oxide. Biochem Pharmacol (2003) 0.90
Mitochondrial dysfunction as a central actor in intellectual disability-related diseases: an overview of Down syndrome, autism, Fragile X and Rett syndrome. Neurosci Biobehav Rev (2014) 0.90
Redox proteomics analysis of HNE-modified proteins in Down syndrome brain: clues for understanding the development of Alzheimer disease. Free Radic Biol Med (2014) 0.89
Impairment of proteostasis network in Down syndrome prior to the development of Alzheimer's disease neuropathology: redox proteomics analysis of human brain. Biochim Biophys Acta (2013) 0.89
Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia. Brain Res (1999) 0.89
Biochemical analysis of protein stability in human brain collected at different post-mortem intervals. Indian J Med Res (2009) 0.89
The Janus face of the heme oxygenase/biliverdin reductase system in Alzheimer disease: it's time for reconciliation. Neurobiol Dis (2013) 0.88
Neuropathological role of PI3K/Akt/mTOR axis in Down syndrome brain. Biochim Biophys Acta (2014) 0.88
Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part II). Amino Acids (2003) 0.88
Down's syndrome: a pathology involving the lack of balance of reactive oxygen species. Free Radic Biol Med (1988) 0.87
Unraveling the complexity of neurodegeneration in brains of subjects with Down syndrome: insights from proteomics. Proteomics Clin Appl (2014) 0.86
Differential susceptibility to neurofibrillary pathology among patients with Down syndrome. Dementia (1996) 0.86
Inhibition of lipid peroxidation and protein oxidation by endogenous and exogenous antioxidants in rat brain microsomes in vitro. Neurosci Lett (2012) 0.86
Formation of ternary complex of human biliverdin reductase-protein kinase Cδ-ERK2 protein is essential for ERK2-mediated activation of Elk1 protein, nuclear factor-κB, and inducible nitric-oxidase synthase (iNOS). J Biol Chem (2011) 0.86
The sequence of human chromosome 21 and implications for research into Down syndrome. Genome Biol (2000) 0.86
Age-associated increases in heme oxygenase-1 and ferritin immunoreactivity in the autopsied brain. Leg Med (Tokyo) (2003) 0.85
Decreased expression and increased oxidation of plasma haptoglobin in Alzheimer disease: Insights from redox proteomics. Free Radic Biol Med (2012) 0.85
Protein levels of genes encoded on chromosome 21 in fetal Down Syndrome brain (Part V): overexpression of phosphatidyl-inositol-glycan class P protein (DSCR5). Amino Acids (2004) 0.84
Protein levels of genes encoded on chromosome 21 in fetal Down syndrome brain: challenging the gene dosage effect hypothesis (Part I). Amino Acids (2003) 0.84
Albumin-bound bilirubin interacts with nitric oxide by a redox mechanism. Antioxid Redox Signal (2006) 0.84
Biological response of human diploid keratinocytes to quinone-producing compounds: role of NAD(P)H:quinone oxidoreductase 1. Int J Biochem Cell Biol (2005) 0.84
The brain in Down syndrome (TRISOMY 21). J Neurol (2002) 0.84
beta-Carotene and cigarette smoke condensate regulate heme oxygenase-1 and its repressor factor Bach1: relationship with cell growth. Antioxid Redox Signal (2006) 0.83
Overexpression of transcription factor BACH1 in fetal Down syndrome brain. J Neural Transm Suppl (2003) 0.83
Redox proteomics analysis to decipher the neurobiology of Alzheimer-like neurodegeneration: overlaps in Down's syndrome and Alzheimer's disease brain. Biochem J (2014) 0.83
Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB. FASEB J (2010) 0.83
The identification of protein biomarkers for oxidative stress in Down syndrome. Expert Rev Proteomics (2011) 0.81
HO-1/BVR-a system analysis in plasma from probable Alzheimer's disease and mild cognitive impairment subjects: a potential biochemical marker for the prediction of the disease. J Alzheimers Dis (2012) 0.81
Redox proteomics and the dynamic molecular landscape of the aging brain. Ageing Res Rev (2013) 0.80
Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1. Hum Genet (1998) 0.80
Identification of senescence-associated genes and their networks under oxidative stress by the analysis of Bach1. Antioxid Redox Signal (2011) 0.80
Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion. Brain Res Brain Res Protoc (2000) 0.79
Regulation of heme oxygenase-1 by transcription factor Bach1 in the mouse brain. Neurosci Lett (2008) 0.78
Plasma nitrate levels are increased in adult Down syndrome patients. Biomarkers (2013) 0.78
Extensive natural variation for cellular hydrogen peroxide release is genetically controlled. PLoS One (2012) 0.77
Mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders. Front Biosci (2007) 1.65
Both mucosal and cutaneous papillomaviruses are in the oral cavity but only alpha genus seems to be associated with cancer. J Clin Virol (2012) 1.07
mTOR signaling in aging and neurodegeneration: At the crossroad between metabolism dysfunction and impairment of autophagy. Neurobiol Dis (2015) 1.03
Human Papillomaviruses, p16INK4a and Akt expression in basal cell carcinoma. J Exp Clin Cancer Res (2011) 0.94
Heat shock proteins and hormesis in the diagnosis and treatment of neurodegenerative diseases. Immun Ageing (2015) 0.86
It Is All about (U)biquitin: Role of Altered Ubiquitin-Proteasome System and UCHL1 in Alzheimer Disease. Oxid Med Cell Longev (2016) 0.82
Heme oxygenase and cyclooxygenase in the central nervous system: a functional interplay. J Neurosci Res (2006) 0.81
Activation of p53 in Down Syndrome and in the Ts65Dn Mouse Brain is Associated with a Pro-Apoptotic Phenotype. J Alzheimers Dis (2016) 0.76
Oxidative signature of cerebrospinal fluid from mild cognitive impairment and Alzheimer disease patients. Free Radic Biol Med (2015) 0.76
CURRENT DEVELOPMENTS IN DRUG ELUTING DEVICES: Introductory Editorial: Drug-Eluting Stents or Drug-Eluting Grafts? Insights from Proteomic Analysis. Drug Target Insights (2017) 0.75
Greater circulating DPP4 activity is associated with impaired flow-mediated dilatation in adults with type 2 diabetes mellitus. Nutr Metab Cardiovasc Dis (2019) 0.75
Redox proteomic analysis of serum from aortic anerurysm patients: insights on oxidation of specific protein target. Mol Biosyst (2016) 0.75