Akt inhibition enhances expansion of potent tumor-specific lymphocytes with memory cell characteristics.

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Published in Cancer Res on November 28, 2014

Authors

Joseph G Crompton1, Madhusudhanan Sukumar2, Rahul Roychoudhuri3, David Clever4, Alena Gros3, Robert L Eil3, Eric Tran3, Ken-Ichi Hanada3, Zhiya Yu3, Douglas C Palmer3, Sid P Kerkar3, Ryan D Michalek5, Trevor Upham3, Anthony Leonardi3, Nicolas Acquavella3, Ena Wang6, Francesco M Marincola6, Luca Gattinoni3, Pawel Muranski3, Mark S Sundrud7, Christopher A Klebanoff8, Steven A Rosenberg3, Douglas T Fearon9, Nicholas P Restifo3

Author Affiliations

1: National Cancer Institute (NCI), NIH, Bethesda, Maryland. Department of Surgery, University of California Los Angeles, Los Angeles, California. Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom. joe.crompton@nih.gov sukumarm2@mail.nih.gov restifo@nih.gov.
2: National Cancer Institute (NCI), NIH, Bethesda, Maryland. joe.crompton@nih.gov sukumarm2@mail.nih.gov restifo@nih.gov.
3: National Cancer Institute (NCI), NIH, Bethesda, Maryland.
4: National Cancer Institute (NCI), NIH, Bethesda, Maryland. Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
5: Metabolon Incorporated, Durham, North Carolina.
6: Sidra Medical and Research Centre, Doha, Qatar.
7: Department of Cancer Biology, The Scripps Research Institute, Jupiter, Florida.
8: National Cancer Institute (NCI), NIH, Bethesda, Maryland. Clinical Investigator Development Program, NCI, NIH, Bethesda, Maryland.
9: Department of Medicine, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.

Associated clinical trials:

Chemotherapy Followed by ESO-1 Lymphocytes and Aldesleukin to Treat Metastatic Cancer | NCT00670748

Prospective Randomized Study of Cell Therapy for Metastatic Melanoma Using Short-Term Cultured Tumor Infiltrating Lymphocytes Plus IL-2 Following Either a Non-Myeloablative Lymphocyte Depleting Chemotherapy Regimen Alone or in Conjunction w/1200 TBI | NCT01319565

Phase II Study of Herzuma® Plus Gedatolisib in Patients With HER-2 Positive Metastatic Breast Cancer | NCT03698383

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