Published in Epigenetics on October 01, 2014
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort. Proc Natl Acad Sci U S A (2016) 0.84
Comparative Genomic, MicroRNA, and Tissue Analyses Reveal Subtle Differences between Non-Diabetic and Diabetic Foot Skin. PLoS One (2015) 0.77
Generation of Induced Pluripotent Stem Cells from Diabetic Foot Ulcer Fibroblasts Using a Nonintegrative Sendai Virus. Cell Reprogram (2016) 0.77
Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications. J Diabetes Res (2015) 0.75
Type 2 diabetes alters mesenchymal stem cell secretome composition and angiogenic properties. J Cell Mol Med (2016) 0.75
Bioconductor: open software development for computational biology and bioinformatics. Genome Biol (2004) 143.19
Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc (2009) 137.99
Exploring the full spectrum of macrophage activation. Nat Rev Immunol (2008) 26.08
Cutaneous wound healing. N Engl J Med (1999) 19.12
Functions of DNA methylation: islands, start sites, gene bodies and beyond. Nat Rev Genet (2012) 15.21
Wound repair and regeneration. Nature (2008) 12.30
Linking DNA methylation and histone modification: patterns and paradigms. Nat Rev Genet (2009) 12.08
High density DNA methylation array with single CpG site resolution. Genomics (2011) 10.35
Effect of intensive therapy on the microvascular complications of type 1 diabetes mellitus. JAMA (2002) 6.61
Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics (2014) 5.93
SWAN: Subset-quantile within array normalization for illumina infinium HumanMethylation450 BeadChips. Genome Biol (2012) 4.99
Distinct DNA methylomes of newborns and centenarians. Proc Natl Acad Sci U S A (2012) 4.26
Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia. J Exp Med (2008) 4.25
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice. J Clin Invest (2011) 3.69
Nucleosome-interacting proteins regulated by DNA and histone methylation. Cell (2010) 3.25
Science, medicine and the future: healing chronic wounds. BMJ (2002) 2.41
Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes. Proc Natl Acad Sci U S A (2008) 2.33
Molecular pathogenesis of chronic wounds: the role of beta-catenin and c-myc in the inhibition of epithelialization and wound healing. Am J Pathol (2005) 2.21
The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview. Diabetes Care (2014) 2.04
A method for the isolation and serial propagation of keratinocytes, endothelial cells, and fibroblasts from a single punch biopsy of human skin. In Vitro Cell Dev Biol Anim (1995) 2.02
Chronic wound pathogenesis and current treatment strategies: a unifying hypothesis. Plast Reconstr Surg (2006) 1.96
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin secretion. PLoS Genet (2014) 1.94
A method to assess genomic DNA methylation using high-performance liquid chromatography/electrospray ionization mass spectrometry. Anal Chem (2002) 1.81
Update on tissue-engineered biological dressings. Tissue Eng (2006) 1.71
Patterns of regulatory activity across diverse human cell types predict tissue identity, transcription factor binding, and long-range interactions. Genome Res (2013) 1.69
Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes. Diabetes (2014) 1.55
Impact of an exercise intervention on DNA methylation in skeletal muscle from first-degree relatives of patients with type 2 diabetes. Diabetes (2012) 1.54
EpiExplorer: live exploration and global analysis of large epigenomic datasets. Genome Biol (2012) 1.40
Epigenome-wide differences in pathology-free regions of multiple sclerosis-affected brains. Nat Neurosci (2013) 1.39
Epigenome-wide association study of fasting measures of glucose, insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study. Diabetes (2013) 1.38
Phenotypic transitions of macrophages orchestrate tissue repair. Am J Pathol (2013) 1.36
Enhanced levels of microRNA-125b in vascular smooth muscle cells of diabetic db/db mice lead to increased inflammatory gene expression by targeting the histone methyltransferase Suv39h1. Diabetes (2010) 1.32
Fibroblasts-a diverse population at the center of it all. Int Rev Cell Mol Biol (2009) 1.27
COL4A1 and COL4A2 mutations and disease: insights into pathogenic mechanisms and potential therapeutic targets. Hum Mol Genet (2012) 1.26
Genome-wide analysis distinguishes hyperglycemia regulated epigenetic signatures of primary vascular cells. Genome Res (2011) 1.22
Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes (2012) 1.21
Epigenetics: deciphering its role in diabetes and its chronic complications. Clin Exp Pharmacol Physiol (2011) 1.17
Epigenetic regulation of cell type-specific expression patterns in the human mammary epithelium. PLoS Genet (2011) 1.15
Fibroblasts cultured from venous ulcers display cellular characteristics of senescence. J Vasc Surg (1998) 1.15
Fibroblasts derived from chronic diabetic ulcers differ in their response to stimulation with EGF, IGF-I, bFGF and PDGF-AB compared to controls. Eur J Cell Biol (2002) 1.14
Gestational diabetes mellitus epigenetically affects genes predominantly involved in metabolic diseases. Epigenetics (2013) 1.13
Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight. Epigenetics (2013) 1.08
Fibroblasts from chronic wounds show altered TGF-beta-signaling and decreased TGF-beta Type II receptor expression. J Cell Physiol (2003) 1.07
Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation. Invest Ophthalmol Vis Sci (2013) 1.05
Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression. Diabetes (2012) 1.04
Regulation of DNA methyltransferase 1 transcription in BRCA1-mutated breast cancer: a novel crosstalk between E2F1 motif hypermethylation and loss of histone H3 lysine 9 acetylation. Mol Cancer (2014) 1.02
Chronic wounds: pathophysiologic and experimental considerations. J Invest Dermatol (1993) 1.02
Topical use of human recombinant epidermal growth factor (h-EGF) in venous ulcers. J Dermatol Surg Oncol (1992) 1.01
Global DNA hypomethylation in peripheral blood mononuclear cells as a biomarker of cancer risk. Cancer Epidemiol Biomarkers Prev (2013) 1.01
Reduced growth of dermal fibroblasts from chronic venous ulcers can be stimulated with growth factors. J Vasc Surg (1997) 0.99
MicroRNA signature in diabetic wound healing: promotive role of miR-21 in fibroblast migration. Int Wound J (2011) 0.97
Metabolic memory and chronic diabetes complications: potential role for epigenetic mechanisms. Curr Diab Rep (2012) 0.96
Defective extracellular matrix reorganization by chronic wound fibroblasts is associated with alterations in TIMP-1, TIMP-2, and MMP-2 activity. J Invest Dermatol (2000) 0.94
Fibroblasts derived from human chronic diabetic wounds have a decreased proliferation rate, which is recovered by the addition of heparin. J Dermatol Sci (1998) 0.92
The influence of patient and wound variables on healing of venous leg ulcers in a randomized controlled trial of growth-arrested allogeneic keratinocytes and fibroblasts. J Vasc Surg (2013) 0.91
Overexpression of the gap junction protein Cx43 as found in diabetic foot ulcers can retard fibroblast migration. Cell Biol Int (2012) 0.91
Gene expression differences in skin fibroblasts in identical twins discordant for type 1 diabetes. Diabetes (2012) 0.89
Epigenetic regulation of depot-specific gene expression in adipose tissue. PLoS One (2013) 0.89
Phenotypic overlap between MMP-13 and the plasminogen activation system during wound healing in mice. PLoS One (2011) 0.86
Disclosing the crosstalk among DNA methylation, transcription factors, and histone marks in human pluripotent cells through discovery of DNA methylation motifs. Genome Res (2013) 0.86
Primary cultured fibroblasts derived from patients with chronic wounds: a methodology to produce human cell lines and test putative growth factor therapy such as GMCSF. J Transl Med (2008) 0.85
Impact of high glucose and proteasome inhibitor MG132 on histone H2A and H2B ubiquitination in rat glomerular mesangial cells. J Diabetes Res (2013) 0.85
Modification of collagen by 3-deoxyglucosone alters wound healing through differential regulation of p38 MAP kinase. PLoS One (2011) 0.85
DNA methylation accumulation and its predetermination of future cancer phenotypes. J Biochem (2014) 0.84
Impaired tissue regeneration corresponds with altered expression of developmental genes that persists in the metabolic memory state of diabetic zebrafish. Wound Repair Regen (2013) 0.83
Transcriptional profiling of human skin fibroblast cell line Hs27 induced by herbal formula Astragali Radix and Rehmanniae Radix. J Ethnopharmacol (2011) 0.83
Understanding variation in transcription factor binding by modeling transcription factor genome-epigenome interactions. PLoS Comput Biol (2013) 0.82
The efficacy of Apligraf in the treatment of diabetic foot ulcers. Plast Reconstr Surg (2006) 0.82
Epigenetic mechanisms in the pathogenesis of diabetic foot ulcers. J Diabetes Complications (2012) 0.80
Irradiation at 636 nm positively affects diabetic wounded and hypoxic cells in vitro. Photomed Laser Surg (2011) 0.78
Growth factors, matrices, and forces combine and control stem cells. Science (2009) 8.46
Hydrogels for tissue engineering: scaffold design variables and applications. Biomaterials (2003) 7.15
Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater (2010) 5.36
Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med (2006) 5.10
Diabetes enhances vulnerability to particulate air pollution-associated impairment in vascular reactivity and endothelial function. Circulation (2005) 5.07
Engineering tumors with 3D scaffolds. Nat Methods (2007) 3.96
Highly stretchable and tough hydrogels. Nature (2012) 3.34
Alginate: properties and biomedical applications. Prog Polym Sci (2012) 3.18
Alginate hydrogels as biomaterials. Macromol Biosci (2006) 2.94
Growth factor delivery-based tissue engineering: general approaches and a review of recent developments. J R Soc Interface (2010) 2.69
Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS. J Clin Invest (2012) 2.67
Circulating adiponectin and resistin levels in relation to metabolic factors, inflammatory markers, and vascular reactivity in diabetic patients and subjects at risk for diabetes. Diabetes Care (2004) 2.55
Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors. Proc Natl Acad Sci U S A (2009) 2.29
Inspiration and application in the evolution of biomaterials. Nature (2009) 2.23
Transcriptional profiling of stroma from inflamed and resting lymph nodes defines immunological hallmarks. Nat Immunol (2012) 2.17
FRET measurements of cell-traction forces and nano-scale clustering of adhesion ligands varied by substrate stiffness. Proc Natl Acad Sci U S A (2005) 2.07
Cancer cell angiogenic capability is regulated by 3D culture and integrin engagement. Proc Natl Acad Sci U S A (2009) 2.07
Noise-enhanced balance control in patients with diabetes and patients with stroke. Ann Neurol (2006) 2.06
Dual growth factor delivery and controlled scaffold degradation enhance in vivo bone formation by transplanted bone marrow stromal cells. Bone (2004) 2.05
Alginate type and RGD density control myoblast phenotype. J Biomed Mater Res (2002) 2.04
Spatio-temporal VEGF and PDGF delivery patterns blood vessel formation and maturation. Pharm Res (2006) 2.03
Defining the cellular precursors to human breast cancer. Proc Natl Acad Sci U S A (2011) 2.01
Infection-mimicking materials to program dendritic cells in situ. Nat Mater (2009) 2.00
Material-based deployment enhances efficacy of endothelial progenitor cells. Proc Natl Acad Sci U S A (2008) 1.96
Coating of VEGF-releasing scaffolds with bioactive glass for angiogenesis and bone regeneration. Biomaterials (2006) 1.88
Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol (2009) 1.83
Combined angiogenic and osteogenic factor delivery enhances bone marrow stromal cell-driven bone regeneration. J Bone Miner Res (2004) 1.83
Non-viral gene delivery regulated by stiffness of cell adhesion substrates. Nat Mater (2005) 1.83
Label-free biomarker detection from whole blood. Nat Nanotechnol (2009) 1.80
Endothelial cell modulation of bone marrow stromal cell osteogenic potential. FASEB J (2005) 1.79
Rapid estrogen receptor signaling is essential for the protective effects of estrogen against vascular injury. Circulation (2012) 1.78
Angiogenic effects of sequential release of VEGF-A165 and PDGF-BB with alginate hydrogels after myocardial infarction. Cardiovasc Res (2007) 1.77
Engineering growing tissues. Proc Natl Acad Sci U S A (2002) 1.76
Polymeric growth factor delivery strategies for tissue engineering. Pharm Res (2003) 1.74
Controlling alginate gel degradation utilizing partial oxidation and bimodal molecular weight distribution. Biomaterials (2005) 1.74
New materials for tissue engineering: towards greater control over the biological response. Trends Biotechnol (2008) 1.69
Percent change in wound area of diabetic foot ulcers over a 4-week period is a robust predictor of complete healing in a 12-week prospective trial. Diabetes Care (2003) 1.68
Guidelines for the treatment of diabetic ulcers. Wound Repair Regen (2007) 1.67
In situ regulation of DC subsets and T cells mediates tumor regression in mice. Sci Transl Med (2009) 1.65
Quantitative assessment of scaffold and growth factor-mediated repair of critically sized bone defects. J Orthop Res (2007) 1.64
Controlled growth factor delivery for tissue engineering. Adv Mater (2009) 1.63
VEGF scaffolds enhance angiogenesis and bone regeneration in irradiated osseous defects. J Bone Miner Res (2006) 1.63
Engineering vascular networks in porous polymer matrices. J Biomed Mater Res (2002) 1.60
Cutaneous microcirculation in the neuropathic diabetic foot improves significantly but not completely after successful lower extremity revascularization. J Vasc Surg (2002) 1.59
Ultraviolet B irradiation induces expansion of intraepithelial tumor cells in a tissue model of early cancer progression. J Invest Dermatol (2003) 1.58
Active scaffolds for on-demand drug and cell delivery. Proc Natl Acad Sci U S A (2010) 1.58
The tensile properties of alginate hydrogels. Biomaterials (2004) 1.57
Cyclic strain enhances matrix mineralization by adult human mesenchymal stem cells via the extracellular signal-regulated kinase (ERK1/2) signaling pathway. J Biomech (2003) 1.56
Cannabidiol attenuates cardiac dysfunction, oxidative stress, fibrosis, and inflammatory and cell death signaling pathways in diabetic cardiomyopathy. J Am Coll Cardiol (2010) 1.56
Poly(ADP-Ribose) polymerase is activated in subjects at risk of developing type 2 diabetes and is associated with impaired vascular reactivity. Circulation (2002) 1.52
Abrogation of E-cadherin-mediated adhesion induces tumor cell invasion in human skin-like organotypic culture. J Invest Dermatol (2003) 1.51
Bioinspired growth of crystalline carbonate apatite on biodegradable polymer substrata. J Am Chem Soc (2002) 1.51
Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care (2003) 1.49
Regulating activation of transplanted cells controls tissue regeneration. Proc Natl Acad Sci U S A (2006) 1.46
Controlling rigidity and degradation of alginate hydrogels via molecular weight distribution. Biomacromolecules (2004) 1.44
Sustained vascular endothelial growth factor delivery enhances angiogenesis and perfusion in ischemic hind limb. Pharm Res (2005) 1.43
An alginate-based hybrid system for growth factor delivery in the functional repair of large bone defects. Biomaterials (2010) 1.42
Regulating myoblast phenotype through controlled gel stiffness and degradation. Tissue Eng (2007) 1.40
Role of vascular endothelial growth factor in bone marrow stromal cell modulation of endothelial cells. Tissue Eng (2003) 1.39
Designing alginate hydrogels to maintain viability of immobilized cells. Biomaterials (2003) 1.39
The forefoot-to-rearfoot plantar pressure ratio is increased in severe diabetic neuropathy and can predict foot ulceration. Diabetes Care (2002) 1.39
Microvascular reactivity and inflammatory cytokines in painful and painless peripheral diabetic neuropathy. J Clin Endocrinol Metab (2009) 1.37
Early changes in the skin microcirculation and muscle metabolism of the diabetic foot. Lancet (2005) 1.37
NF-κB inhibits osteogenic differentiation of mesenchymal stem cells by promoting β-catenin degradation. Proc Natl Acad Sci U S A (2013) 1.35
Analysis of microenvironmental factors contributing to basement membrane assembly and normalized epidermal phenotype. J Invest Dermatol (2003) 1.35
Integrated approach to designing growth factor delivery systems. FASEB J (2007) 1.35
Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro. Biomaterials (2005) 1.34
Quantifying the relation between adhesion ligand-receptor bond formation and cell phenotype. Proc Natl Acad Sci U S A (2006) 1.34
Differentiation stage alters matrix control of stem cells. J Biomed Mater Res A (2008) 1.33
Salt fusion: an approach to improve pore interconnectivity within tissue engineering scaffolds. Tissue Eng (2002) 1.33
Can tissue engineering concepts advance tumor biology research? Trends Biotechnol (2010) 1.32
Effects of VEGF temporal and spatial presentation on angiogenesis. Biomaterials (2009) 1.32
Effect of diabetes on renal medullary oxygenation during water diuresis. Diabetes Care (2002) 1.30
Injectable preformed scaffolds with shape-memory properties. Proc Natl Acad Sci U S A (2012) 1.28
Effect of substrate mechanics on chondrocyte adhesion to modified alginate surfaces. Arch Biochem Biophys (2004) 1.26
E-cadherin suppression accelerates squamous cell carcinoma progression in three-dimensional, human tissue constructs. Cancer Res (2005) 1.26
Mechanical strain regulates endothelial cell patterning in vitro. Tissue Eng (2007) 1.26
Macroscale delivery systems for molecular and cellular payloads. Nat Mater (2013) 1.25
Beta1 integrin expression on endothelial cells is required for angiogenesis but not for vasculogenesis. Dev Dyn (2008) 1.24
Temporally regulated delivery of VEGF in vitro and in vivo. J Biomed Mater Res A (2006) 1.23
Depletion of central BDNF in mice impedes terminal differentiation of new granule neurons in the adult hippocampus. Mol Cell Neurosci (2008) 1.22
Inflammation and neuropeptides: the connection in diabetic wound healing. Expert Rev Mol Med (2009) 1.22
Mechanisms involved in the development and healing of diabetic foot ulceration. Diabetes (2012) 1.21
Polymers to direct cell fate by controlling the microenvironment. Curr Opin Biotechnol (2007) 1.20
Polymers for pro- and anti-angiogenic therapy. Biomaterials (2007) 1.19
A combined approach to data mining of textual and structured data to identify cancer-related targets. BMC Bioinformatics (2006) 1.16
Protein-based signaling systems in tissue engineering. Curr Opin Biotechnol (2003) 1.16
Engineering RGD nanopatterned hydrogels to control preosteoblast behavior: a combined computational and experimental approach. Biomaterials (2007) 1.16
Long-term in vivo gene expression via delivery of PEI-DNA condensates from porous polymer scaffolds. Hum Gene Ther (2005) 1.15
Fabrication and in vitro testing of polymeric delivery system for condensed DNA. J Biomed Mater Res A (2003) 1.15
Enhancing microvascular formation and vessel maturation through temporal control over multiple pro-angiogenic and pro-maturation factors. Biomaterials (2013) 1.14
A bioinspired soft actuated material. Adv Mater (2013) 1.14
Sustained delivery of plasmid DNA from polymeric scaffolds for tissue engineering. Adv Drug Deliv Rev (2006) 1.13
The basement membrane microenvironment directs the normalization and survival of bioengineered human skin equivalents. Matrix Biol (2007) 1.13
The use of medical hyperspectral technology to evaluate microcirculatory changes in diabetic foot ulcers and to predict clinical outcomes. Diabetes Care (2007) 1.12
In vivo time-gated fluorescence imaging with biodegradable luminescent porous silicon nanoparticles. Nat Commun (2013) 1.11
Foot small muscle atrophy is present before the detection of clinical neuropathy. Diabetes Care (2005) 1.10
Locally enhanced angiogenesis promotes transplanted cell survival. Tissue Eng (2004) 1.10
Design of biodegradable hydrogel for the local and sustained delivery of angiogenic plasmid DNA. Pharm Res (2008) 1.10
Microenvironmental regulation of biomacromolecular therapies. Nat Rev Drug Discov (2007) 1.10