Recanalization and Reperfusion Therapies of Acute Ischemic Stroke: What have We Learned, What are the Major Research Questions, and Where are We Headed?

PubWeight™: 0.82‹?›

🔗 View Article (PMC 4237052)

Published in Front Neurol on November 19, 2014

Authors

Meritxell Gomis1, Antoni Dávalos1

Author Affiliations

1: Stroke Unit, Neurosciences Department, Hospital Universitari Germans Trias i Pujol , Badalona , Spain.

Associated clinical trials:

Endovascular Treatment for Small Core and Proximal Occlusion Ischemic Stroke (ESCAPE) | NCT01778335

Endovascular Revascularization With Solitaire Device Versus Best Medical Therapy in Anterior Circulation Stroke Within 8 Hours (REVASCAT) | NCT01692379

Assess the Penumbra System in the Treatment of Acute Stroke (THERAPY) | NCT01429350

Trial and Cost Effectiveness Evaluation of Intra-arterial Thrombectomy in Acute Ischemic Stroke (THRACE) | NCT01062698

Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) | NCT01745692

NCT01655746

Articles cited by this

Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med (1995) 47.15

Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med (2008) 28.42

Endovascular therapy after intravenous t-PA versus t-PA alone for stroke. N Engl J Med (2013) 14.78

Association of outcome with early stroke treatment: pooled analysis of ATLANTIS, ECASS, and NINDS rt-PA stroke trials. Lancet (2004) 12.92

Stenting versus aggressive medical therapy for intracranial arterial stenosis. N Engl J Med (2011) 12.76

Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA (1999) 12.75

Thrombolysis with alteplase for acute ischaemic stroke in the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST): an observational study. Lancet (2007) 10.74

Magnetic resonance imaging profiles predict clinical response to early reperfusion: the diffusion and perfusion imaging evaluation for understanding stroke evolution (DEFUSE) study. Ann Neurol (2006) 10.51

A trial of imaging selection and endovascular treatment for ischemic stroke. N Engl J Med (2013) 9.97

Effects of alteplase beyond 3 h after stroke in the Echoplanar Imaging Thrombolytic Evaluation Trial (EPITHET): a placebo-controlled randomised trial. Lancet Neurol (2008) 9.02

Solitaire flow restoration device versus the Merci Retriever in patients with acute ischaemic stroke (SWIFT): a randomised, parallel-group, non-inferiority trial. Lancet (2012) 8.76

Endovascular treatment for acute ischemic stroke. N Engl J Med (2013) 8.45

Mechanical thrombectomy for acute ischemic stroke: final results of the Multi MERCI trial. Stroke (2008) 8.45

The impact of recanalization on ischemic stroke outcome: a meta-analysis. Stroke (2007) 8.06

Safety and efficacy of mechanical embolectomy in acute ischemic stroke: results of the MERCI trial. Stroke (2005) 8.05

Trevo versus Merci retrievers for thrombectomy revascularisation of large vessel occlusions in acute ischaemic stroke (TREVO 2): a randomised trial. Lancet (2012) 7.89

Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke (2003) 7.75

The penumbra pivotal stroke trial: safety and effectiveness of a new generation of mechanical devices for clot removal in intracranial large vessel occlusive disease. Stroke (2009) 7.65

The Thrombolysis in Myocardial Infarction (TIMI) trial. Phase I findings. TIMI Study Group. N Engl J Med (1985) 7.29

MRI profile and response to endovascular reperfusion after stroke (DEFUSE 2): a prospective cohort study. Lancet Neurol (2012) 5.91

Combined intravenous and intra-arterial recanalization for acute ischemic stroke: the Interventional Management of Stroke Study. Stroke (2004) 4.67

Recombinant tissue plasminogen activator for acute ischaemic stroke: an updated systematic review and meta-analysis. Lancet (2012) 4.66

The Desmoteplase in Acute Ischemic Stroke Trial (DIAS): a phase II MRI-based 9-hour window acute stroke thrombolysis trial with intravenous desmoteplase. Stroke (2004) 4.39

Intravenous desmoteplase in patients with acute ischaemic stroke selected by MRI perfusion-diffusion weighted imaging or perfusion CT (DIAS-2): a prospective, randomised, double-blind, placebo-controlled study. Lancet Neurol (2008) 3.98

The Interventional Management of Stroke (IMS) II Study. Stroke (2007) 3.83

A randomized trial of tenecteplase versus alteplase for acute ischemic stroke. N Engl J Med (2012) 3.81

Revascularization results in the Interventional Management of Stroke II trial. AJNR Am J Neuroradiol (2008) 3.32

Dose Escalation of Desmoteplase for Acute Ischemic Stroke (DEDAS): evidence of safety and efficacy 3 to 9 hours after stroke onset. Stroke (2006) 3.03

Site of arterial occlusion identified by transcranial Doppler predicts the response to intravenous thrombolysis for stroke. Stroke (2007) 2.93

Occurrence and predictors of futile recanalization following endovascular treatment among patients with acute ischemic stroke: a multicenter study. AJNR Am J Neuroradiol (2010) 2.80

Mechanical thrombectomy with the Solitaire AB device in large artery occlusions of the anterior circulation: a pilot study. Stroke (2010) 2.78

Recommendations on angiographic revascularization grading standards for acute ischemic stroke: a consensus statement. Stroke (2013) 2.50

Collateral blood vessels in acute ischaemic stroke: a potential therapeutic target. Lancet Neurol (2011) 2.46

Solitaire FR thrombectomy system: immediate results in 56 consecutive acute ischemic stroke patients. J Neurointerv Surg (2011) 2.14

Prospective, multicenter, single-arm study of mechanical thrombectomy using Solitaire Flow Restoration in acute ischemic stroke. Stroke (2013) 1.94

Rescue, combined, and stand-alone thrombectomy in the management of large vessel occlusion stroke using the solitaire device: a prospective 50-patient single-center study: timing, safety, and efficacy. Stroke (2011) 1.81

Prognosis of untreated strokes due to anterior circulation proximal intracranial arterial occlusions detected by use of computed tomography angiography. JAMA Neurol (2014) 1.78

Trevo System: single-center experience with a novel mechanical thrombectomy device. J Neuroimaging (2011) 1.73

Stent-assisted mechanical recanalization for treatment of acute intracerebral artery occlusions. Stroke (2010) 1.69

Neurothrombectomy for the treatment of acute ischemic stroke: results from the TREVO study. Cerebrovasc Dis (2013) 1.53

Mechanical thrombectomy with a self-expanding retrievable intracranial stent (Solitaire AB): experience in 26 patients with acute cerebral artery occlusion. AJNR Am J Neuroradiol (2011) 1.47

Recanalization and clinical outcome of occlusion sites at baseline CT angiography in the Interventional Management of Stroke III trial. Radiology (2014) 1.46

Efficacy and safety of tissue plasminogen activator 3 to 4.5 hours after acute ischemic stroke: a metaanalysis. Stroke (2009) 1.44

Greater effect of stroke thrombolysis in the presence of arterial obstruction. Ann Neurol (2011) 1.44

Retrospective multicenter study of Solitaire FR for revascularization in the treatment of acute ischemic stroke. Stroke (2012) 1.41

Collaterals at angiography and outcomes in the Interventional Management of Stroke (IMS) III trial. Stroke (2014) 1.38

Progressive derangement of periinfarct viable tissue in ischemic stroke. J Cereb Blood Flow Metab (1992) 1.31

Years of disability-adjusted life gained as a result of thrombolytic therapy for acute ischemic stroke. Stroke (2010) 1.28

Refining angiographic biomarkers of revascularization: improving outcome prediction after intra-arterial therapy. Stroke (2013) 1.27

Single-center experience of cerebral artery thrombectomy using the TREVO device in 60 patients with acute ischemic stroke. Stroke (2012) 1.27

Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial. Stroke (2011) 1.22

Stent placement for flow restoration in acute ischemic stroke: a single-center experience with the Solitaire stent system. AJNR Am J Neuroradiol (2011) 1.18

Futile recanalization in mechanical embolectomy trials: a call to improve selection of patients for revascularization. Stroke (2010) 1.17

Acute ischemic stroke: imaging-guided tenecteplase treatment in an extended time window. Neurology (2009) 1.14

Self-expanding stents for recanalization of acute cerebrovascular occlusions. AJNR Am J Neuroradiol (2007) 1.13

Initial experience with a self-expanding retrievable stent for recanalization of large vessel occlusions in acute ischemic stroke. Neuroradiology (2011) 1.05

Collateral lessons from recent acute ischemic stroke trials. Neurol Res (2014) 1.05

Intracranial thrombectomy using the Solitaire stent: a historical vignette. J Neurointerv Surg (2011) 1.05

Safety of intra-arterial thrombolysis in the postoperative period. Stroke (2001) 1.04

Mechanical thrombectomy in severe acute stroke: preliminary results of the Solitaire stent. J Neurol Neurosurg Psychiatry (2011) 1.01

A retrieval thrombectomy technique with the Solitaire stent in a large cerebral artery occlusion. Acta Neurochir (Wien) (2011) 1.01

Safety and effectiveness of endovascular therapy after 8 hours of acute ischemic stroke onset and wake-up strokes. Stroke (2009) 1.00

Refinement of the magnetic resonance diffusion-perfusion mismatch concept for thrombolytic patient selection: insights from the desmoteplase in acute stroke trials. Stroke (2012) 1.00

Recanalization with stent-based mechanical thrombectomy in anterior circulation major ischemic stroke. J Clin Neurosci (2011) 0.99

Is general anaesthesia preferable to conscious sedation in the treatment of acute ischaemic stroke with intra-arterial mechanical thrombectomy? A review of the literature. Neuroradiology (2012) 0.98

Endovascular mechanical clot retrieval in a broad ischemic stroke cohort. AJNR Am J Neuroradiol (2006) 0.97

Endovascular treatment of acute ischemic stroke: the end or just the beginning? Neurosurg Focus (2014) 0.96

Door-to-puncture: a practical metric for capturing and enhancing system processes associated with endovascular stroke care, preliminary results from the rapid reperfusion registry. J Am Heart Assoc (2014) 0.95

CLOTBUST-Hands Free: pilot safety study of a novel operator-independent ultrasound device in patients with acute ischemic stroke. Stroke (2013) 0.94

Outcomes of a contemporary cohort of 536 consecutive patients with acute ischemic stroke treated with endovascular therapy. Stroke (2014) 0.93

Mechanical thrombectomy in acute embolic stroke: preliminary results with the revive device. Stroke (2011) 0.93

Use of the New Solitaire (TM) AB Device for Mechanical Thrombectomy when Merci Clot Retriever Has Failed to Remove the Clot. A Case Report. Interv Neuroradiol (2009) 0.93

Imaging-based selection in acute ischemic stroke trials - a quest for imaging sweet spots. Ann N Y Acad Sci (2012) 0.93

Mechanical thrombectomy compared to local-intraarterial thrombolysis in carotid T and middle cerebral artery occlusions: a single center experience. Clin Neuroradiol (2011) 0.91

Early single center experience with the solitaire thrombectomy device for the treatment of acute ischemic stroke. Interv Neuroradiol (2011) 0.91

IMS-III and SYNTHESIS Expansion trials of endovascular therapy in acute ischemic stroke: how can we improve? Stroke (2013) 0.91

Temporary stenting and retrieval of the self-expandable, intracranial stent in acute middle cerebral artery occlusion. Neuroradiology (2009) 0.89

Trevo versus solitaire a head-to-head comparison between two heavy weights of clot retrieval. J Neuroimaging (2012) 0.86

Effects of age on outcome in the SENTIS trial: better outcomes in elderly patients. Cerebrovasc Dis (2012) 0.85

Preliminary experience with the use of self-expanding stent as a thrombectomy device in ischemic stroke. Neurol Res (2011) 0.85

Endovascular treatment for acute ischemic stroke patients: implications and interpretation of IMS III, MR RESCUE, and SYNTHESIS EXPANSION trials: A report from the Working Group of International Congress of Interventional Neurology. J Vasc Interv Neurol (2014) 0.84

Self-expanding stent-assisted middle cerebral artery recanalization: technical note. Neuroradiology (2006) 0.84

Treatment of acute ischemic stroke: feasibility of primary or secondary use of a self-expanding stent (Neuroform) during local intra-arterial thrombolysis. Neuroradiology (2011) 0.81

The Desmoteplase in Acute Ischemic Stroke (DIAS) clinical trial program. Int J Stroke (2012) 0.81

Mechanical thrombectomy with solitaire stent retrieval for acute ischemic stroke in a Brazilian population. Clinics (Sao Paulo) (2012) 0.80

The SITS-MOST registry. Neurol Sci (2006) 0.80

Intra-arterial thrombolysis in patients treated with warfarin. Cerebrovasc Dis (2005) 0.80

[New options in the therapeutic management of acute ischaemic stroke. Good results with combined i. v. and i. a. lysis and mechanical thrombectomy]. Fortschr Neurol Psychiatr (2010) 0.76