Reduced IFNλ4 activity is associated with improved HCV clearance and reduced expression of interferon-stimulated genes.

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Published in Nat Commun on December 23, 2014

Authors

Ewa Terczyńska-Dyla1, Stephanie Bibert2, Francois H T Duong3, Ilona Krol3, Sanne Jørgensen1, Emilie Collinet2, Zoltán Kutalik4, Vincent Aubert5, Andreas Cerny6, Laurent Kaiser7, Raffaele Malinverni8, Alessandra Mangia9, Darius Moradpour10, Beat Müllhaupt11, Francesco Negro12, Rosanna Santoro9, David Semela13, Nasser Semmo14, Swiss Hepatitis C Cohort Study Group, Markus H Heim3, Pierre-Yves Bochud2, Rune Hartmann1

Author Affiliations

1: Department of Molecular Biology and Genetics, Aarhus University, Aarhus DK-8000, Denmark.
2: Infectious Diseases Service, Department of Medicine, University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland.
3: 1] Department of Biomedicine, University of Basel, Basel CH-4031, Switzerland [2] Division of Gastroenterology and Hepatology, University Hospital Basel, Basel CH-4031, Switzerland.
4: 1] Institute of Social and Preventive Medicine, University Hospital (CHUV) and University of Lausanne, Lausanne 1010, Switzerland [2] Swiss Institute of Bioinformatics, Lausanne 1015, Switzerland.
5: Service of Immunology and Allergology, Department of Medicine, University Hospital and University of Lausanne, Lausanne 1011, Switzerland.
6: Fondazione Epatocentro Ticino, Sede Moncucco, Lugano 6900, Switzerland.
7: Laboratory of Virology, Division of Infectious Diseases and Division of Laboratory Medicine, University Hospitals of Geneva and Medical School, University of Geneva, Geneva 1211, Switzerland.
8: Pourtalès Hospital, Neuchâtel 2000, Switzerland.
9: Liver Unit, Scientific Research Institute Casa Sollievo della Sofferenza, San Giovanni Rotondo 71013, Italy.
10: Division of Gastroenterology and Hepatology, University Hospital and University of Lausanne, Lausanne CH-1011, Switzerland.
11: Division of Gastroenterology and Hepatology, University Hospital of Zurich, Zurich 8091, Switzerland.
12: Division of Clinical Pathology and Division of Gastroenterology and Hepatology, University Hospitals, Geneva 1211, Switzerland.
13: Division of Gastroenterology, Canton Hospital, St Gallen CH-9007, Switzerland.
14: Service of Hepatology, Department of Clinical Research, University of Bern, Bern CH-3010, Switzerland.

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