Salinomycin and other polyether ionophores are a new class of antiscarring agent.

PubWeight™: 0.83‹?›

🔗 View Article (PMID 25538236)

Published in J Biol Chem on December 23, 2014

Authors

Collynn F Woeller1, Charles W O'Loughlin2, Elisa Roztocil2, Steven E Feldon2, Richard P Phipps3

Author Affiliations

1: From the Department of Environmental Medicine and.
2: Flaum Eye Institute, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642.
3: From the Department of Environmental Medicine and Flaum Eye Institute, School of Medicine and Dentistry, University of Rochester, Rochester, New York 14642 Richard_Phipps@urmc.rochester.edu.

Articles cited by this

Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol (2002) 14.80

Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell (2009) 12.96

The myofibroblast: one function, multiple origins. Am J Pathol (2007) 8.64

TGFβ signalling in context. Nat Rev Mol Cell Biol (2012) 8.08

MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol (1996) 6.91

The myofibroblast in wound healing and fibrocontractive diseases. J Pathol (2003) 6.16

Formation and function of the myofibroblast during tissue repair. J Invest Dermatol (2007) 6.11

Targeting the TGFβ signalling pathway in disease. Nat Rev Drug Discov (2012) 4.30

Graves' ophthalmopathy. N Engl J Med (2010) 4.24

Recent developments in myofibroblast biology: paradigms for connective tissue remodeling. Am J Pathol (2012) 4.13

Tissue repair, contraction, and the myofibroblast. Wound Repair Regen (2005) 3.70

The myofibroblast in pulmonary fibrosis. Chest (2002) 3.46

Inhibition of transforming growth factor (TGF)-beta1-induced extracellular matrix with a novel inhibitor of the TGF-beta type I receptor kinase activity: SB-431542. Mol Pharmacol (2002) 3.36

Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6. J Biol Chem (1998) 3.21

Transforming growth factor beta stimulates collagen-matrix contraction by fibroblasts: implications for wound healing. Proc Natl Acad Sci U S A (1988) 2.69

On the nature of hypertrophic scars and keloids: a review. Plast Reconstr Surg (1999) 2.55

Hypertrophic scarring and keloids: pathomechanisms and current and emerging treatment strategies. Mol Med (2010) 2.51

Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol (1997) 2.47

Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells. Proc Natl Acad Sci U S A (2011) 2.12

Pulmonary fibrosis: patterns and perpetrators. J Clin Invest (2012) 2.05

TGFbeta pathobiology in the eye. Lab Invest (2006) 1.85

Fibrosis and diseases of the eye. J Clin Invest (2007) 1.79

The myofibroblast matrix: implications for tissue repair and fibrosis. J Pathol (2013) 1.73

Salinomycin induces apoptosis and overcomes apoptosis resistance in human cancer cells. Biochem Biophys Res Commun (2009) 1.65

The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis. J Clin Invest (2003) 1.61

Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep (2002) 1.52

Salinomycin as a drug for targeting human cancer stem cells. J Biomed Biotechnol (2012) 1.50

The TGFbeta superfamily signaling pathway. Wiley Interdiscip Rev Dev Biol (2012) 1.40

Wnt3a induces myofibroblast differentiation by upregulating TGF-β signaling through SMAD2 in a β-catenin-dependent manner. PLoS One (2011) 1.32

Comparative effectiveness of therapies for Graves' hyperthyroidism: a systematic review and network meta-analysis. J Clin Endocrinol Metab (2013) 1.29

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. Immunol Invest (2006) 1.21

A p38 MAPK inhibitor, FR-167653, ameliorates murine bleomycin-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol (2002) 1.20

Inhibition of p38 mitogen-activated protein kinase and transforming growth factor-beta1/Smad signaling pathways modulates the development of fibrosis in adriamycin-induced nephropathy. Am J Pathol (2006) 1.13

Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation. Acta Pharmacol Sin (2007) 1.10

The eye and thyroid disease. Curr Opin Ophthalmol (2008) 1.05

Immune mechanisms in thyroid eye disease. Thyroid (2008) 1.05

Effects of salinomycin on cancer stem cell in human lung adenocarcinoma A549 cells. Med Chem (2011) 1.03

Salinomycin: a new cancer drug candidate. Chem Biol Drug Des (2012) 1.02

Requirement of transforming growth factor beta-activated kinase 1 for transforming growth factor beta-induced alpha-smooth muscle actin expression and extracellular matrix contraction in fibroblasts. Arthritis Rheum (2009) 0.99

Salinomycin in cancer: A new mission for an old agent. Mol Med Rep (2011) 0.97

TGF-β signaling via TAK1 pathway: role in kidney fibrosis. Semin Nephrol (2012) 0.96

Synthesis, cytotoxicity and antibacterial activity of new esters of polyether antibiotic - salinomycin. Eur J Med Chem (2014) 0.96

The myofibroblast, multiple origins for major roles in normal and pathological tissue repair. Fibrogenesis Tissue Repair (2012) 0.95

TRPV1 potentiates TGFβ-induction of corneal myofibroblast development through an oxidative stress-mediated p38-SMAD2 signaling loop. PLoS One (2013) 0.93

Multiple regulatory genes in the salinomycin biosynthetic gene cluster of Streptomyces albus CCM 4719. Folia Microbiol (Praha) (2007) 0.92

Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. Invest Ophthalmol Vis Sci (2013) 0.92

Novel anti-adipogenic activity produced by human fibroblasts. Am J Physiol Cell Physiol (2010) 0.91

TGFbeta family members are key mediators in the induction of myofibroblast phenotype of human adipose tissue progenitor cells by macrophages. PLoS One (2012) 0.90

p38 kinase inhibitor approved for idiopathic pulmonary fibrosis. Nat Biotechnol (2011) 0.89

Sequential analysis of myofibroblast differentiation and transforming growth factor-β1/Smad pathway activation in murine pulmonary fibrosis. J Nippon Med Sch (2012) 0.85

Regulation of myofibroblast differentiation by convergence of the Wnt and TGF-beta1/Smad signaling pathways. J Mol Cell Cardiol (2009) 0.85

Decreased expression of p38 MAPK mediates protective effects of hydrogen sulfide on hepatic fibrosis. Eur Rev Med Pharmacol Sci (2013) 0.82

Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts. J Biol Chem (2011) 0.82

A phase I study of the metal ionophore clioquinol in patients with advanced hematologic malignancies. Clin Lymphoma Myeloma Leuk (2012) 0.80

Improvement of thyroid eye disease following treatment with the cyclooxygenase-2 selective inhibitor celecoxib. Thyroid (2008) 0.79

Determination of the ionophoric coccidiostats narasin, monensin, lasalocid and salinomycin in eggs by liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2005) 0.78