Published in J Biol Chem on December 29, 2014
Modeling the Regulatory Mechanisms by Which NLRX1 Modulates Innate Immune Responses to Helicobacter pylori Infection. PLoS One (2015) 0.79
The Translational Repressor 4E-BP1 Contributes to Diabetes-Induced Visual Dysfunction. Invest Ophthalmol Vis Sci (2016) 0.76
Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cell Signal (2016) 0.76
Differential expression of breast cancer-resistance protein, lung resistance protein, and multidrug resistance protein 1 in retinas of streptozotocin-induced diabetic mice. Int J Ophthalmol (2017) 0.75
Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy. Sci Rep (2016) 0.75
Activation of the stress response kinase JNK attenuates insulin action in retina through a p70S6K1 dependent mechanism. J Biol Chem (2016) 0.75
Troxerutin Attenuates Enhancement of Hepatic Gluconeogenesis by Inhibiting NOD Activation-Mediated Inflammation in High-Fat Diet-Treated Mice. Int J Mol Sci (2016) 0.75
The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. The Diabetes Control and Complications Trial Research Group. N Engl J Med (1993) 102.56
Global quantification of mammalian gene expression control. Nature (2011) 22.36
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev (2004) 7.51
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev (2001) 5.37
Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia. J Biol Chem (1995) 5.20
Molecular understanding of hyperglycemia's adverse effects for diabetic complications. JAMA (2002) 4.18
Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model. Am J Pathol (1994) 3.76
Vascular endothelial growth factors and angiogenesis in eye disease. Prog Retin Eye Res (2003) 3.53
Endogenous VEGF is required for visual function: evidence for a survival role on müller cells and photoreceptors. PLoS One (2008) 3.46
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol Cell Biol (2002) 3.30
Transgenic mice with increased expression of vascular endothelial growth factor in the retina: a new model of intraretinal and subretinal neovascularization. Am J Pathol (1997) 2.73
Hyperglycemic pseudohypoxia and diabetic complications. Diabetes (1993) 2.62
Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol Cell Biol (1998) 2.59
A hypoxia-controlled cap-dependent to cap-independent translation switch in breast cancer. Mol Cell (2007) 2.44
Müller cell changes in human diabetic retinopathy. Diabetes (1998) 2.34
Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Mol Cell Biol (2005) 1.99
Vascular endothelial growth factor is present in glial cells of the retina and optic nerve of human subjects with nonproliferative diabetic retinopathy. Invest Ophthalmol Vis Sci (1997) 1.81
Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate. Arch Ophthalmol (1996) 1.64
Müller cell-derived VEGF is essential for diabetes-induced retinal inflammation and vascular leakage. Diabetes (2010) 1.63
Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin. Diabetes (2006) 1.58
Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts. J Biol Chem (1998) 1.46
Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF-4E and eIF-4G. Am J Physiol (1997) 1.40
Inhibition of oxygen-induced retinopathy in RTP801-deficient mice. Invest Ophthalmol Vis Sci (2004) 1.39
Elevated corticosterone associated with food deprivation upregulates expression in rat skeletal muscle of the mTORC1 repressor, REDD1. J Nutr (2009) 1.35
An RNA G-quadruplex is essential for cap-independent translation initiation in human VEGF IRES. J Am Chem Soc (2010) 1.27
The hypoxic proteome is influenced by gene-specific changes in mRNA translation. Radiother Oncol (2005) 1.22
An upstream open reading frame within an IRES controls expression of a specific VEGF-A isoform. Nucleic Acids Res (2008) 1.20
Role of intravitreal inflammatory cytokines and angiogenic factors in proliferative diabetic retinopathy. Curr Eye Res (2012) 1.20
Activation of endoplasmic reticulum stress by hyperglycemia is essential for Müller cell-derived inflammatory cytokine production in diabetes. Diabetes (2012) 1.19
Translational induction of VEGF internal ribosome entry site elements during the early response to ischemic stress. Circ Res (2007) 1.18
REDD1 enhances protein phosphatase 2A-mediated dephosphorylation of Akt to repress mTORC1 signaling. Sci Signal (2014) 1.12
Increased prostaglandin E2 (PGE2) levels in proliferative diabetic retinopathy, and correlation with VEGF and inflammatory cytokines. Invest Ophthalmol Vis Sci (2012) 1.09
Vascular endothelial cell growth factor-a: not just for endothelial cells anymore. Am J Pathol (2007) 1.07
Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis. J Biol Chem (2012) 1.07
Therapeutic interventions against inflammatory and angiogenic mediators in proliferative diabetic retinopathy. Mediators Inflamm (2012) 1.02
Treatment of proliferative diabetic retinopathy with anti-VEGF agents. Acta Ophthalmol (2011) 1.01
Glutaredoxin regulates autocrine and paracrine proinflammatory responses in retinal glial (muller) cells. J Biol Chem (2008) 1.00
Chronic hyperglycemia reduces substrate oxidation and impairs metabolic switching of human myotubes. Biochim Biophys Acta (2010) 0.96
High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications. Biochem Biophys Res Commun (2013) 0.95
Differential roles of hyperglycemia and hypoinsulinemia in diabetes induced retinal cell death: evidence for retinal insulin resistance. PLoS One (2011) 0.94
Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes (2010) 0.93
Calcium mediates high glucose-induced HIF-1α and VEGF expression in cultured rat retinal Müller cells through CaMKII-CREB pathway. Acta Pharmacol Sin (2012) 0.88
Hyperglycemia mediates a shift from cap-dependent to cap-independent translation via a 4E-BP1-dependent mechanism. Diabetes (2013) 0.88
Reduced REDD1 expression contributes to activation of mTORC1 following electrically induced muscle contraction. Am J Physiol Endocrinol Metab (2014) 0.87
Inhibition of high glucose-induced VEGF release in retinal ganglion cells by RNA interference targeting G protein-coupled receptor 91. Exp Eye Res (2013) 0.86
Hyperglycemia-induced O-GlcNAcylation and truncation of 4E-BP1 protein in liver of a mouse model of type 1 diabetes. J Biol Chem (2011) 0.86
Many roads from mTOR to eIF4F. Biochem Soc Trans (2013) 0.85
O-GlcNAc modification of transcription factor Sp1 mediates hyperglycemia-induced VEGF-A upregulation in retinal cells. Invest Ophthalmol Vis Sci (2014) 0.83
Role of transcription factor modifications in the pathogenesis of insulin resistance. Exp Diabetes Res (2011) 0.82
mTORC1-independent reduction of retinal protein synthesis in type 1 diabetes. Diabetes (2014) 0.79
RTP801 gene expression is differentially upregulated in retinopathy and is silenced by PF-04523655, a 19-Mer siRNA directed against RTP801. Invest Ophthalmol Vis Sci (2014) 0.77