Published in Therap Adv Gastroenterol on January 01, 2015
A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | NCT01829971
MicroRNAs Expression in the Ileal Pouch of Patients with Ulcerative Colitis Is Robustly Up-Regulated and Correlates with Disease Phenotypes. PLoS One (2016) 1.38
MicroRNAs in colorectal carcinoma - from pathogenesis to therapy. J Exp Clin Cancer Res (2016) 1.00
Inflammatory Bowel Disease: Genetics, Epigenetics, and Pathogenesis. Front Immunol (2015) 0.98
Down-regulation of microRNAs of the miR-200 family and up-regulation of Snail and Slug in inflammatory bowel diseases - hallmark of epithelial-mesenchymal transition. J Cell Mol Med (2016) 0.78
miRiaD: A Text Mining Tool for Detecting Associations of microRNAs with Diseases. J Biomed Semantics (2016) 0.77
Recent insights into the molecular pathogenesis of Crohn's disease: a review of emerging therapeutic targets. Clin Exp Gastroenterol (2016) 0.76
miRNAs as new molecular insights into inflammatory bowel disease: Crucial regulators in autoimmunity and inflammation. World J Gastroenterol (2016) 0.76
Nutritional Modulation of Gene Expression: Might This be of Benefit to Individuals with Crohn's Disease? Front Immunol (2015) 0.76
Harnessing the Power of Posttranscriptional Gene Silencing in Crohn's Disease. Clin Transl Gastroenterol (2016) 0.75
Dietary Gluten-Induced Gut Dysbiosis Is Accompanied by Selective Upregulation of microRNAs with Intestinal Tight Junction and Bacteria-Binding Motifs in Rhesus Macaque Model of Celiac Disease. Nutrients (2016) 0.75
Genetic and Epigenetic Determinants in Autoinflammatory Diseases. Front Immunol (2017) 0.75
Circulating MicroRNA223 is a New Biomarker for Inflammatory Bowel Disease. Medicine (Baltimore) (2016) 0.75
Effects of Herb-Partitioned Moxibustion on the miRNA Expression Profiles in Colon from Rats with DSS-Induced Ulcerative Colitis. Evid Based Complement Alternat Med (2017) 0.75
RNA interference-based nanosystems for inflammatory bowel disease therapy. Int J Nanomedicine (2016) 0.75
Diet, Gut Microbiome and Epigenetics: Emerging Links with Inflammatory Bowel Diseases and Prospects for Management and Prevention. Nutrients (2017) 0.75
miR-4728-3p Functions as a Tumor Suppressor in Ulcerative Colitis-associated Colorectal Neoplasia Through Regulation of Focal Adhesion Signaling. Inflamm Bowel Dis (2017) 0.75
Omics Approaches to Identify Potential Biomarkers of Inflammatory Diseases in the Focal Adhesion Complex. Genomics Proteomics Bioinformatics (2017) 0.75
MicroRNAs: target recognition and regulatory functions. Cell (2009) 92.17
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell (1993) 64.62
Combinatorial microRNA target predictions. Nat Genet (2005) 50.48
Identification of novel genes coding for small expressed RNAs. Science (2001) 44.44
Most mammalian mRNAs are conserved targets of microRNAs. Genome Res (2008) 37.16
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans. Cell (1993) 33.79
Circulating microRNAs as stable blood-based markers for cancer detection. Proc Natl Acad Sci U S A (2008) 33.65
Silencing of microRNAs in vivo with 'antagomirs'. Nature (2005) 32.56
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature (2001) 28.24
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseases. Cell Res (2008) 20.59
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA. Nature (2000) 19.15
Switching from repression to activation: microRNAs can up-regulate translation. Science (2007) 17.00
microRNA functions. Annu Rev Cell Dev Biol (2007) 15.74
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet (2006) 15.14
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility. Nat Genet (2007) 13.74
Therapeutic microRNA delivery suppresses tumorigenesis in a murine liver cancer model. Cell (2009) 11.10
Adenovirus-associated virus vector-mediated gene transfer in hemophilia B. N Engl J Med (2011) 11.01
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts. Nature (2008) 10.73
Treatment of HCV infection by targeting microRNA. N Engl J Med (2013) 9.91
Deletion polymorphism upstream of IRGM associated with altered IRGM expression and Crohn's disease. Nat Genet (2008) 9.52
Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science (2006) 9.17
miR-181a is an intrinsic modulator of T cell sensitivity and selection. Cell (2007) 9.08
Genetics and pathogenesis of inflammatory bowel disease. Nature (2011) 7.79
MicroRNAs in stress signaling and human disease. Cell (2012) 6.93
Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07
miRNA profiling of naïve, effector and memory CD8 T cells. PLoS One (2007) 5.43
CD8(+) T-cell responses to adeno-associated virus capsid in humans. Nat Med (2007) 5.24
MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proc Natl Acad Sci U S A (2007) 4.92
MicroRNAs in the miR-106b family regulate p21/CDKN1A and promote cell cycle progression. Mol Cell Biol (2008) 4.76
Target protectors reveal dampening and balancing of Nodal agonist and antagonist by miR-430. Science (2007) 4.72
Micro-RNA profiling reveals a role for miR-29 in human and murine liver fibrosis. Hepatology (2010) 4.72
miR-21 mediates fibrogenic activation of pulmonary fibroblasts and lung fibrosis. J Exp Med (2010) 4.71
Blood cell origin of circulating microRNAs: a cautionary note for cancer biomarker studies. Cancer Prev Res (Phila) (2011) 4.64
MicroRNA functions in stress responses. Mol Cell (2010) 4.46
Ustekinumab induction and maintenance therapy in refractory Crohn's disease. N Engl J Med (2012) 4.41
Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum (2008) 4.08
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blasts. Cell (2010) 4.07
Mechanisms and optimization of in vivo delivery of lipophilic siRNAs. Nat Biotechnol (2007) 4.02
Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res (2007) 3.89
A synonymous variant in IRGM alters a binding site for miR-196 and causes deregulation of IRGM-dependent xenophagy in Crohn's disease. Nat Genet (2011) 3.59
Characterizing light-regulated retinal microRNAs reveals rapid turnover as a common property of neuronal microRNAs. Cell (2010) 3.57
Systemic leukocyte-directed siRNA delivery revealing cyclin D1 as an anti-inflammatory target. Science (2008) 3.51
MicroRNA-122 plays a critical role in liver homeostasis and hepatocarcinogenesis. J Clin Invest (2012) 3.46
RNA interference in the clinic: challenges and future directions. Nat Rev Cancer (2010) 3.43
Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res (2003) 3.39
MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha. Gastroenterology (2008) 3.29
Essential metabolic, anti-inflammatory, and anti-tumorigenic functions of miR-122 in liver. J Clin Invest (2012) 3.14
Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13
Coordinated regulation of cell cycle transcripts by p53-Inducible microRNAs, miR-192 and miR-215. Cancer Res (2008) 2.86
ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis. Gastroenterology (2010) 2.83
MicroRNA-29, a key regulator of collagen expression in systemic sclerosis. Arthritis Rheum (2010) 2.53
Crohn's disease-associated adherent-invasive E. coli are selectively favoured by impaired autophagy to replicate intracellularly. Cell Microbiol (2009) 2.23
miR-126 functions as a tumour suppressor in human gastric cancer. Cancer Lett (2010) 2.17
MicroRNA-126 inhibits invasion in non-small cell lung carcinoma cell lines. Biochem Biophys Res Commun (2008) 2.15
Chemical modification of siRNAs for in vivo use. Oligonucleotides (2008) 2.03
Silencing microRNA-155 ameliorates experimental autoimmune encephalomyelitis. J Immunol (2011) 1.93
Nanoparticle-based therapy in an in vivo microRNA-155 (miR-155)-dependent mouse model of lymphoma. Proc Natl Acad Sci U S A (2012) 1.91
Identification of microRNAs associated with ileal and colonic Crohn's disease. Inflamm Bowel Dis (2010) 1.89
The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families. PLoS One (2011) 1.81
SOCS1 restricts dendritic cells' ability to break self tolerance and induce antitumor immunity by regulating IL-12 production and signaling. J Clin Invest (2005) 1.75
Silencing of microRNA-155 in mice during acute inflammatory response leads to derepression of c/ebp Beta and down-regulation of G-CSF. Nucleic Acids Res (2009) 1.72
Identification of a microRNA signature in renal fibrosis: role of miR-21. Am J Physiol Renal Physiol (2011) 1.70
MicroRNA-205-directed transcriptional activation of tumor suppressor genes in prostate cancer. Cancer (2010) 1.70
Posttranscriptional regulation of interleukin-10 expression by hsa-miR-106a. Proc Natl Acad Sci U S A (2009) 1.64
Short hairpin RNA-expressing bacteria elicit RNA interference in mammals. Nat Biotechnol (2006) 1.61
Progress in microRNA delivery. J Control Release (2013) 1.58
Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. PLoS One (2010) 1.54
The roles of binding site arrangement and combinatorial targeting in microRNA repression of gene expression. Genome Biol (2007) 1.53
Environmental risk factors for inflammatory bowel disease. Gastroenterol Hepatol (N Y) (2010) 1.48
Engineering mucosal RNA interference in vivo. Mol Ther (2006) 1.43
MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis. Gastroenterology (2013) 1.41
Peripheral blood microRNAs distinguish active ulcerative colitis and Crohn's disease. Inflamm Bowel Dis (2010) 1.38
Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis. J Gastroenterol Hepatol (2010) 1.38
Chemical modification and design of anti-miRNA oligonucleotides. Gene Ther (2011) 1.36
Lessons from miR-143/145: the importance of cell-type localization of miRNAs. Nucleic Acids Res (2014) 1.34
Epidemiology of inflammatory bowel disease in a German twin cohort: results of a nationwide study. Inflamm Bowel Dis (2008) 1.32
MiR-155 is overexpressed in patients with atopic dermatitis and modulates T-cell proliferative responses by targeting cytotoxic T lymphocyte-associated antigen 4. J Allergy Clin Immunol (2010) 1.32
MicroRNA-29c functions as a tumor suppressor by direct targeting oncogenic SIRT1 in hepatocellular carcinoma. Oncogene (2013) 1.30
miR-199a-3p targets CD44 and reduces proliferation of CD44 positive hepatocellular carcinoma cell lines. Biochem Biophys Res Commun (2010) 1.30
Serological antibodies in inflammatory bowel disease: a systematic review. Inflamm Bowel Dis (2011) 1.30
Circulating microRNA is a biomarker of pediatric Crohn disease. J Pediatr Gastroenterol Nutr (2011) 1.29
Circulating MicroRNA in inflammatory bowel disease. J Crohns Colitis (2012) 1.24
A single anti-microRNA antisense oligodeoxyribonucleotide (AMO) targeting multiple microRNAs offers an improved approach for microRNA interference. Nucleic Acids Res (2009) 1.23
miR-200b precursor can ameliorate renal tubulointerstitial fibrosis. PLoS One (2010) 1.23
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. Immunity (2013) 1.21
miR-143 and miR-145 are downregulated in ulcerative colitis: putative regulators of inflammation and protooncogenes. Inflamm Bowel Dis (2011) 1.20
Novel RNA-based strategies for therapeutic gene silencing. Mol Ther (2010) 1.20
Role of MicroRNAs in Fibrosis. Open Rheumatol J (2012) 1.14
MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation. J Biol Chem (2009) 1.12
Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodium-induced murine experimental colitis and human ulcerative colitis. J Pathol (2011) 1.11
Crohn's disease-associated adherent invasive Escherichia coli modulate levels of microRNAs in intestinal epithelial cells to reduce autophagy. Gastroenterology (2013) 1.11
miR-200b inhibits TGF-β1-induced epithelial-mesenchymal transition and promotes growth of intestinal epithelial cells. Cell Death Dis (2013) 1.09
Up-regulation of microRNA-126 may contribute to pathogenesis of ulcerative colitis via regulating NF-kappaB inhibitor IκBα. PLoS One (2012) 1.06
miR-141 Regulates colonic leukocytic trafficking by targeting CXCL12β during murine colitis and human Crohn's disease. Gut (2013) 1.06
Identification of serum and tissue micro-RNA expression profiles in different stages of inflammatory bowel disease. Clin Exp Immunol (2013) 1.06
Genome-wide maps of circulating miRNA biomarkers for ulcerative colitis. PLoS One (2012) 1.05
MicroRNA-21 knockout improve the survival rate in DSS induced fatal colitis through protecting against inflammation and tissue injury. PLoS One (2013) 1.02
Why interleukin-10 supplementation does not work in Crohn's disease patients. World J Gastroenterol (2013) 1.02
IL-10 gene therapy prevents TNBS-induced colitis. Gene Ther (2002) 1.01