Published in Aging (Albany NY) on December 01, 2014
A Critical Examination of the "Bad Luck" Explanation of Cancer Risk. Cancer Prev Res (Phila) (2015) 1.68
Toward an evolutionary model of cancer: Considering the mechanisms that govern the fate of somatic mutations. Proc Natl Acad Sci U S A (2015) 0.99
Cancer: Risk factors and random chances. Nature (2015) 0.99
Aging as a driver of leukemogenesis. Sci Transl Med (2015) 0.91
Cancer stem cell targeted therapy: progress amid controversies. Oncotarget (2015) 0.88
Aging-associated inflammation promotes selection for adaptive oncogenic events in B cell progenitors. J Clin Invest (2015) 0.88
Systemic Problems: A perspective on stem cell aging and rejuvenation. Aging (Albany NY) (2015) 0.88
Aging, Clonality, and Rejuvenation of Hematopoietic Stem Cells. Trends Mol Med (2016) 0.86
Stochastic modeling reveals an evolutionary mechanism underlying elevated rates of childhood leukemia. Proc Natl Acad Sci U S A (2016) 0.81
Preventing clonal evolutionary processes in cancer: Insights from mathematical models. Proc Natl Acad Sci U S A (2015) 0.80
Coronary artery calcifications predict long term cardiovascular events in non diabetic Caucasian hemodialysis patients. Aging (Albany NY) (2015) 0.78
The evolution of lifespan and age-dependent cancer risk. Trends Cancer (2016) 0.75
Evolved Cellular Mechanisms to Respond to Genotoxic Insults: Implications for Radiation-Induced Hematologic Malignancies. Radiat Res (2015) 0.75
Changing mutational and adaptive landscapes and the genesis of cancer. Biochim Biophys Acta (2017) 0.75
Aging, Metabolism, and Cancer Development: from Peto's Paradox to the Warburg Effect. Aging Dis (2017) 0.75
Cell state plasticity, stem cells, EMT, and the generation of intra-tumoral heterogeneity. NPJ Breast Cancer (2017) 0.75
Recurring mutations found by sequencing an acute myeloid leukemia genome. N Engl J Med (2009) 33.09
Cancer genome landscapes. Science (2013) 25.33
The clonal evolution of tumor cell populations. Science (1976) 24.39
The hallmarks of aging. Cell (2013) 14.29
The age distribution of cancer and a multi-stage theory of carcinogenesis. Br J Cancer (1954) 11.33
BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros. Nature (2008) 10.12
The origin and evolution of mutations in acute myeloid leukemia. Cell (2012) 9.66
The fate of competing beneficial mutations in an asexual population. Genetica (1998) 9.60
DNA damage, aging, and cancer. N Engl J Med (2009) 7.56
DNA methylation age of human tissues and cell types. Genome Biol (2013) 7.48
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia. Nature (2014) 6.83
A new theory on cancer-inducing mechanism. Br J Cancer (1953) 6.53
Understanding the odd science of aging. Cell (2005) 6.50
The distribution of fitness effects of new mutations. Nat Rev Genet (2007) 6.42
Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32
Why don't we get more cancer? A proposed role of the microenvironment in restraining cancer progression. Nat Med (2011) 5.54
Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol (2007) 5.48
Two genetic hits (more or less) to cancer. Nat Rev Cancer (2001) 5.19
Accumulation of driver and passenger mutations during tumor progression. Proc Natl Acad Sci U S A (2010) 4.47
A microenvironmental model of carcinogenesis. Nat Rev Cancer (2008) 4.40
Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell (2006) 4.07
Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia. Sci Transl Med (2012) 4.05
AML1/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation. Proc Natl Acad Sci U S A (2000) 3.68
Multistage carcinogenesis and the incidence of colorectal cancer. Proc Natl Acad Sci U S A (2002) 3.64
The population dynamics of cancer: a Darwinian perspective. Int J Epidemiol (2006) 3.59
Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels. Aging Cell (2009) 3.16
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age. Proc Natl Acad Sci U S A (2011) 2.96
Hematopoietic stem cells proliferate until after birth and show a reversible phase-specific engraftment defect. J Clin Invest (2006) 2.79
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work. Nat Rev Cancer (2012) 2.71
p53-mediated hematopoietic stem and progenitor cell competition. Cell Stem Cell (2010) 2.65
Self-renewing hematopoietic stem cell is the primary target in pathogenesis of human chronic lymphocytic leukemia. Cancer Cell (2011) 2.62
Clonal origin of chronic myelocytic leukemia in man. Proc Natl Acad Sci U S A (1967) 2.48
Peto's Paradox: evolution's prescription for cancer prevention. Trends Ecol Evol (2011) 2.48
Cancer and ageing: convergent and divergent mechanisms. Nat Rev Mol Cell Biol (2007) 2.27
Evidence that hematopoiesis may be a stochastic process in vivo. Nat Med (1996) 2.26
Cancer and aging: a model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol (2002) 2.08
Answering the ultimate question "what is the proximal cause of aging?". Aging (Albany NY) (2012) 2.04
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells. J Exp Med (2011) 1.95
Manifestations and mechanisms of stem cell aging. J Cell Biol (2011) 1.93
United States life tables, 2009. Natl Vital Stat Rep (2014) 1.89
Leukocyte telomere dynamics and human hematopoietic stem cell kinetics during somatic growth. Exp Hematol (2009) 1.66
Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol (2010) 1.65
The replication rate of human hematopoietic stem cells in vivo. Blood (2011) 1.58
In vivo kinetics of murine hemopoietic stem cells. Blood (2000) 1.55
Stem cell aging: mechanisms, regulators and therapeutic opportunities. Nat Med (2014) 1.52
Aging and genome maintenance. Ann N Y Acad Sci (2005) 1.39
Estimating human hematopoietic stem cell kinetics using granulocyte telomere lengths. Exp Hematol (2004) 1.33
Impact of genomic damage and ageing on stem cell function. Nat Cell Biol (2014) 1.33
It takes a tissue to make a tumor: epigenetics, cancer and the microenvironment. J Mammary Gland Biol Neoplasia (2001) 1.32
Challenging the axiom: does the occurrence of oncogenic mutations truly limit cancer development with age? Oncogene (2012) 1.29
Impaired DNA replication within progenitor cell pools promotes leukemogenesis. PLoS Biol (2005) 1.25
The evolving concept of tumor microenvironments. Bioessays (2007) 1.20
The age incidence of chronic myeloid leukemia can be explained by a one-mutation model. Proc Natl Acad Sci U S A (2006) 1.17
Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc Natl Acad Sci U S A (2010) 1.16
Modern Biological Theories of Aging. Aging Dis (2010) 1.15
Multistage models of carcinogenesis. Environ Health Perspect (1985) 1.15
Mechanisms of hematopoietic stem cell aging. Exp Gerontol (2009) 1.11
Irradiation alters selection for oncogenic mutations in hematopoietic progenitors. Cancer Res (2009) 1.09
Evolved tumor suppression: why are we so good at not getting cancer? Cancer Res (2011) 1.05
Synchronous waves of failed soft sweeps in the laboratory: remarkably rampant clonal interference of alleles at a single locus. Genetics (2013) 1.00
The effect of one additional driver mutation on tumor progression. Evol Appl (2012) 0.90
Estimation of the number of mutations necessary to cause chronic myeloid leukaemia from epidemiological data. Br J Haematol (1996) 0.88
Law of the Minimum paradoxes. Bull Math Biol (2010) 0.85
Age-related mutation accumulation at a lacZ reporter locus in normal and tumor tissues of Trp53-deficient mice. Mutat Res (2002) 0.84
Heritability of life span in mice and its implication for direct and indirect selection for longevity. Genetica (2000) 0.84
Cdc42 and aging of hematopoietic stem cells. Curr Opin Hematol (2013) 0.79