Glucagon-like receptor 1 agonists and DPP-4 inhibitors: potential therapies for the treatment of stroke.

PubWeight™: 0.81‹?›

🔗 View Article (PMID 25669907)

Published in J Cereb Blood Flow Metab on February 11, 2015

Authors

Vladimer Darsalia1, Martin Larsson1, David Nathanson1, Thomas Klein2, Thomas Nyström1, Cesare Patrone1

Author Affiliations

1: Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Internal Medicine, Stockholm, Sweden.
2: Boehringer Ingelheim Pharma GmbH & Co. KG, Biberach, Germany.

Associated clinical trials:

Sitagliptin Cardiovascular Outcomes Study (MK-0431-082) (TECOS) | NCT00790205

CAROLINA: Cardiovascular Outcome Study of Linagliptin Versus Glimepiride in Patients With Type 2 Diabetes | NCT01243424

Liraglutide Effect and Action in Diabetes: Evaluation of Cardiovascular Outcome Results (LEADER®) | NCT01179048

Exenatide Study of Cardiovascular Event Lowering Trial (EXSCEL): A Trial To Evaluate Cardiovascular Outcomes After Treatment With Exenatide Once Weekly In Patients With Type 2 Diabetes Mellitus | NCT01144338

Cardiovascular and Renal Microvascular Outcome Study With Linagliptin in Patients With Type 2 Diabetes Mellitus (CARMELINA) | NCT01897532

A Study to Evaluate Cardiovascular Outcomes in Patients With Type 2 Diabetes Treated With ITCA 650 | NCT01455896

Articles cited by this

The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet (2006) 15.76

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus. N Engl J Med (2013) 11.34

Alogliptin after acute coronary syndrome in patients with type 2 diabetes. N Engl J Med (2013) 8.74

2-year efficacy and safety of linagliptin compared with glimepiride in patients with type 2 diabetes inadequately controlled on metformin: a randomised, double-blind, non-inferiority trial. Lancet (2012) 4.11

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism. Proc Natl Acad Sci U S A (2009) 2.15

Neuroprotection for ischemic stroke: two decades of success and failure. NeuroRx (2004) 1.71

Design of the liraglutide effect and action in diabetes: evaluation of cardiovascular outcome results (LEADER) trial. Am Heart J (2013) 1.62

Peptide hormone exendin-4 stimulates subventricular zone neurogenesis in the adult rodent brain and induces recovery in an animal model of Parkinson's disease. J Neurosci Res (2008) 1.58

Risk of cardiovascular disease events in patients with type 2 diabetes prescribed the glucagon-like peptide 1 (GLP-1) receptor agonist exenatide twice daily or other glucose-lowering therapies: a retrospective analysis of the LifeLink database. Diabetes Care (2010) 1.54

Safety of dipeptidyl peptidase-4 inhibitors: a meta-analysis of randomized clinical trials. Curr Med Res Opin (2011) 1.48

Exendin-4, a glucagon-like peptide-1 receptor agonist, provides neuroprotection in mice transient focal cerebral ischemia. J Cereb Blood Flow Metab (2011) 1.40

Receptors for the incretin glucagon-like peptide-1 are expressed on neurons in the central nervous system. Neuroreport (2009) 1.22

Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia. J Neurosci Res (2011) 1.20

Glucagon-like peptide-1 receptor activation reduces ischaemic brain damage following stroke in Type 2 diabetic rats. Clin Sci (Lond) (2012) 1.19

The DPP-4 inhibitor linagliptin counteracts stroke in the normal and diabetic mouse brain: a comparison with glimepiride. Diabetes (2012) 1.13

Central effects of GLP-1: new opportunities for treatments of neurodegenerative diseases. J Endocrinol (2014) 1.07

Dipeptidyl peptidase-4 inhibitors do not increase the risk of cardiovascular events in type 2 diabetes: a cohort study. Acta Diabetol (2014) 0.94

Repeated administration of exendin-4 reduces focal cerebral ischemia-induced infarction in rats. Brain Res (2011) 0.91

Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. J Neurosci (2014) 0.91

Reducing the risk of stroke in type 2 diabetes: pathophysiological and therapeutic perspectives. J Neurol (2009) 0.91

Exendin-4 reduces ischemic brain injury in normal and aged type 2 diabetic mice and promotes microglial M2 polarization. PLoS One (2014) 0.89

Glucagon-like peptide-1 decreases intracerebral glucose content by activating hexokinase and changing glucose clearance during hyperglycemia. J Cereb Blood Flow Metab (2012) 0.88

Pleiotropic mechanisms for the glucose-lowering action of DPP-4 inhibitors. Diabetes (2014) 0.87

Neuroprotective effects of liraglutide for stroke model of rats. Int J Mol Sci (2013) 0.87

Neuroprotective and anti-apoptotic effects of liraglutide in the rat brain following focal cerebral ischemia. Neuroscience (2014) 0.85

Alogliptin, a dipeptidylpeptidase-4 inhibitor, for patients with diabetes mellitus type 2, induces tolerance to focal cerebral ischemia in non-diabetic, normal mice. Brain Res (2013) 0.85

Exenatide in acute ischemic stroke. Int J Stroke (2013) 0.79

Antidiabetic treatment, stroke severity and outcome. World J Diabetes (2014) 0.78

Dipeptidyl peptidase IV, aminopeptidase N and DPIV/APN-like proteases in cerebral ischemia. J Neuroinflammation (2012) 0.78

Related expressional change of HIF-1α to the neuroprotective activity of exendin-4 in transient global ischemia. Neuroreport (2014) 0.77