Published in Oncogene on February 16, 2015
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Knockdown of CMTM3 promotes metastasis of gastric cancer via the STAT3/Twist1/EMT signaling pathway. Oncotarget (2016) 0.77
Increased Hemodynamic Load in Early Embryonic Stages Alters Endocardial to Mesenchymal Transition. Front Physiol (2017) 0.77
Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1. Oncogene (2016) 0.77
Regulation of Multi-drug Resistance in hepatocellular carcinoma cells is TRPC6/Calcium Dependent. Sci Rep (2016) 0.77
Rewiring of the apoptotic TGF-β-SMAD/NFκB pathway through an oncogenic function of p27 in human papillary thyroid cancer. Oncogene (2016) 0.76
Profilin-1 mediated cell-cycle arrest: searching for drug targets. Cell Cycle (2015) 0.75
B7-H3 regulates migration and invasion in salivary gland adenoid cystic carcinoma via the JAK2/STAT3 signaling pathway. Am J Transl Res (2017) 0.75
p27(KIP1) loss promotes proliferation and phagocytosis but prevents epithelial-mesenchymal transition in RPE cells after photoreceptor damage. Mol Vis (2016) 0.75
Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion. Oncogene (2016) 0.75
Role of STAT3 and FOXO1 in the Divergent Therapeutic Responses of Non-metastatic and Metastatic Bladder Cancer Cells to miR-145. Mol Cancer Ther (2017) 0.75
p27(Kip1) promotes invadopodia turnover and invasion through the regulation of the PAK1/Cortactin pathway. Elife (2017) 0.75
Prognostic Importance of Cell Cycle Regulators Cyclin D1 (CCND1) and Cyclin-Dependent Kinase Inhibitor 1B (CDKN1B/p27) in Sporadic Gastric Cancers. Gastroenterol Res Pract (2016) 0.75
Clonal cooperativity in heterogenous cancers. Semin Cell Dev Biol (2016) 0.75
Musashi-2 promotes migration and invasion in bladder cancer via activation of the JAK2/STAT3 pathway. Lab Invest (2016) 0.75
Epithelial-mesenchymal transition and inflammation at the site of the primary tumor. Semin Cancer Biol (2017) 0.75
Suppression of CIP4/Par6 attenuates TGF-β1-induced epithelial-mesenchymal transition in NRK-52E cells. Int J Mol Med (2017) 0.75
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The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol (2007) 6.22
PKB/Akt phosphorylates p27, impairs nuclear import of p27 and opposes p27-mediated G1 arrest. Nat Med (2002) 5.79
The murine gene p27Kip1 is haplo-insufficient for tumour suppression. Nature (1998) 5.40
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A Technical Assessment of the Utility of Reverse Phase Protein Arrays for the Study of the Functional Proteome in Non-microdissected Human Breast Cancers. Clin Proteomics (2010) 3.25
p27Kip1 modulates cell migration through the regulation of RhoA activation. Genes Dev (2004) 3.16
mTOR-raptor binds and activates SGK1 to regulate p27 phosphorylation. Mol Cell (2008) 3.06
Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype. Genes Dev (2007) 3.00
Unravelling the complexity of metastasis - molecular understanding and targeted therapies. Nat Rev Cancer (2011) 2.64
Oncogenic roles of EMT-inducing transcription factors. Nat Cell Biol (2014) 2.40
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Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition. J Biol Chem (2011) 1.70
Phosphorylation of p27Kip1 at threonine 198 by p90 ribosomal protein S6 kinases promotes its binding to 14-3-3 and cytoplasmic localization. J Biol Chem (2003) 1.59
TWISTing an embryonic transcription factor into an oncoprotein. Oncogene (2010) 1.57
STAT3 as a central regulator of tumor metastases. Curr Mol Med (2009) 1.57
RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility. Proc Natl Acad Sci U S A (2009) 1.46
Relocalized p27Kip1 tumor suppressor functions as a cytoplasmic metastatic oncogene in melanoma. Cancer Res (2007) 1.35
C-terminal phosphorylation controls the stability and function of p27kip1. EMBO J (2006) 1.35
p27(Kip1) directly represses Sox2 during embryonic stem cell differentiation. Cell Stem Cell (2012) 1.23
Proteasome-dependent degradation of p27/kip1 in gliomas. J Neuropathol Exp Neurol (1999) 1.19
Cytoplasmic p27 is oncogenic and cooperates with Ras both in vivo and in vitro. Oncogene (2011) 1.12
Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27kip1 in breast cancer. Cell Cycle (2004) 1.10
p27Kip1 represses transcription by direct interaction with p130/E2F4 at the promoters of target genes. Oncogene (2011) 1.09
The cell cycle inhibitor p27Kip¹ controls self-renewal and pluripotency of human embryonic stem cells by regulating the cell cycle, Brachyury and Twist. Cell Cycle (2011) 1.09
STAT3 can be activated through paracrine signaling in breast epithelial cells. BMC Cancer (2008) 1.01
Biological correlates of p27 compartmental expression in prostate cancer. J Urol (2006) 0.98
High cytoplasmic expression of p27(Kip1) is associated with a worse cancer-specific survival in clear cell renal cell carcinoma. BJU Int (2011) 0.98
Phosphorylation of p27Kip1 by JAK2 directly links cytokine receptor signaling to cell cycle control. Oncogene (2011) 0.96
Invasion and metastasis models for studying RhoGDI2 in bladder cancer. Methods Enzymol (2008) 0.92
The combination of low cytoplasmic and high nuclear expression of p27 predicts a better prognosis in high-grade astrocytoma. Anticancer Res (2009) 0.86
PI3K/mTOR inhibition can impair tumor invasion and metastasis in vivo despite a lack of antiproliferative action in vitro: implications for targeted therapy. Breast Cancer Res Treat (2013) 0.84