Multiple facets of histone variant H2AX: a DNA double-strand-break marker with several biological functions.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMC 4357700)

Published in Nucleic Acids Res on February 20, 2015

Authors

Valentina Turinetto1, Claudia Giachino2

Author Affiliations

1: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy valentina.turinetto@unito.it.
2: Department of Clinical and Biological Sciences, University of Turin, Orbassano, Turin, Italy claudia.giachino@unito.it.

Articles citing this

Single-molecule decoding of combinatorially modified nucleosomes. Science (2016) 1.48

Helicobacter saguini, a Novel Helicobacter Isolated from Cotton-Top Tamarins with Ulcerative Colitis, Has Proinflammatory Properties and Induces Typhlocolitis and Dysplasia in Gnotobiotic IL-10-/- Mice. Infect Immun (2016) 0.89

Molecular pathology endpoints useful for aging studies. Ageing Res Rev (2016) 0.89

Cbx4 maintains the epithelial lineage identity and cell proliferation in the developing stratified epithelium. J Cell Biol (2015) 0.88

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53. Cell Death Dis (2016) 0.86

Essential role of autoactivation circuitry on Aurora B-mediated H2AX-pS121 in mitosis. Nat Commun (2016) 0.84

NF-κB oscillations translate into functionally related patterns of gene expression. Elife (2016) 0.82

Di (2-ethylhexyl) Phthalate Exposure Impairs Growth of Antral Follicle in Mice. PLoS One (2016) 0.80

Histone variants as emerging regulators of embryonic stem cell identity. Epigenetics (2015) 0.79

Effect of ATM and HDAC Inhibition on Etoposide-Induced DNA Damage in Porcine Early Preimplantation Embryos. PLoS One (2015) 0.79

Norepinephrine-induced apoptotic and hypertrophic responses in H9c2 cardiac myoblasts are characterized by different repertoire of reactive oxygen species generation. Redox Biol (2015) 0.76

The Structural Determinants behind the Epigenetic Role of Histone Variants. Genes (Basel) (2015) 0.76

A Checkpoint-Related Function of the MCM Replicative Helicase Is Required to Avert Accumulation of RNA:DNA Hybrids during S-phase and Ensuing DSBs during G2/M. PLoS Genet (2016) 0.76

The Fra-1-miR-134-SDS22 feedback loop amplifies ERK/JNK signaling and reduces chemosensitivity in ovarian cancer cells. Cell Death Dis (2016) 0.76

Novel Helicobacter species H.japonicum isolated from laboratory mice from Japan induces typhlocolitis and lower bowel carcinoma in C57BL/129 IL10-/- mice. Carcinogenesis (2016) 0.75

γH2Ax Expression as a Potential Biomarker Differentiating between Low and High Grade Cervical Squamous Intraepithelial Lesions (SIL) and High Risk HPV Related SIL. PLoS One (2017) 0.75

Response of Mouse Zygotes Treated with Mild Hydrogen Peroxide as a Model to Reveal Novel Mechanisms of Oxidative Stress-Induced Injury in Early Embryos. Oxid Med Cell Longev (2016) 0.75

Autophagy deficient keratinocytes display increased DNA damage, senescence and aberrant lipid composition after oxidative stress in vitro and in vivo. Redox Biol (2016) 0.75

Accumulation of DNA damage in the aged hematopoietic stem cell compartment. Semin Hematol (2016) 0.75

The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii. Front Microbiol (2016) 0.75

Cataloging antineoplastic agents according to their effectiveness against platinum-resistant and platinum-sensitive ovarian carcinoma cell lines. J Transl Sci (2016) 0.75

pATM and γH2AX are effective radiation biomarkers in assessing the radiosensitivity of (12)C(6+) in human tumor cells. Cancer Cell Int (2017) 0.75

Antimitotic activity of DY131 and the estrogen-related receptor beta 2 (ERRβ2) splice variant in breast cancer. Oncotarget (2016) 0.75

Citron Kinase Deficiency Leads to Chromosomal Instability and TP53-Sensitive Microcephaly. Cell Rep (2017) 0.75

G-rich DNA-induced stress response blocks type-I-IFN but not CXCL10 secretion in monocytes. Sci Rep (2016) 0.75

Cytological basis of sterility in male and female hybrids between sibling species of grey voles Microtus arvalis and M. levis. Sci Rep (2016) 0.75

Sexually dimorphic expression of Dmrt1 and γH2AX in germ stem cells during gonadal development in Xenopus laevis. FEBS Open Bio (2016) 0.75

Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions. PLoS One (2016) 0.75

Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice. PLoS One (2016) 0.75

The cnidarian Hydractinia echinata employs canonical and highly adapted histones to pack its DNA. Epigenetics Chromatin (2016) 0.75

Chromosomal Integrity after UV Irradiation Requires FANCD2-Mediated Repair of Double Strand Breaks. PLoS Genet (2016) 0.75

Identification of evolutionarily conserved DNA damage response genes that alter sensitivity to cisplatin. Oncotarget (2016) 0.75

Oocyte exposure to ZnO nanoparticles inhibits early embryonic development through the γ-H2AX and NF-κB signaling pathways. Oncotarget (2017) 0.75

Overexpression of Exportin-5 Overrides the Inhibitory Effect of miRNAs Regulation Control and Stabilize Proteins via Posttranslation Modifications in Prostate Cancer. Neoplasia (2017) 0.75

Differential expression profile analysis of DNA damage repair genes in CD133(+)/CD133(-) colorectal cancer cells. Oncol Lett (2017) 0.75

Induced Pluripotent Stem Cells: Advances in the Quest for Genetic Stability during Reprogramming Process. Int J Mol Sci (2017) 0.75

The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance. Genes (Basel) (2017) 0.75

Articles cited by this

(truncated to the top 100)

The language of covalent histone modifications. Nature (2000) 44.92

Crystal structure of the nucleosome core particle at 2.8 A resolution. Nature (1997) 44.55

DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J Biol Chem (1998) 28.13

The role of chromatin during transcription. Cell (2007) 26.48

The serial cultivation of human diploid cell strains. Exp Cell Res (1961) 25.11

The spindle-assembly checkpoint in space and time. Nat Rev Mol Cell Biol (2007) 18.33

Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol (1999) 16.81

Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol (2007) 16.55

A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55

Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev (2001) 12.46

Genomic instability in mice lacking histone H2AX. Science (2002) 10.23

Choreography of the DNA damage response: spatiotemporal relationships among checkpoint and repair proteins. Cell (2004) 9.74

Mutation selection and the natural history of cancer. Nature (1975) 9.73

DNA damage foci at dysfunctional telomeres. Curr Biol (2003) 9.08

Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks. Nat Cell Biol (2003) 8.55

Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell (2006) 8.53

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks. Cell (2005) 8.39

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol (2009) 7.74

Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem (2001) 7.35

Recombinational DNA double-strand breaks in mice precede synapsis. Nat Genet (2001) 6.91

Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol Cell (2004) 6.48

Requirement of the MRN complex for ATM activation by DNA damage. EMBO J (2003) 6.23

Mechanism and control of meiotic recombination initiation. Curr Top Dev Biol (2001) 6.15

Reversal of human cellular senescence: roles of the p53 and p16 pathways. EMBO J (2003) 5.61

A role for Saccharomyces cerevisiae histone H2A in DNA repair. Nature (2001) 5.28

Chromatin challenges during DNA replication and repair. Cell (2007) 5.23

Senescence-messaging secretome: SMS-ing cellular stress. Nat Rev Cancer (2009) 5.02

Dynamics of global gene expression changes during mouse preimplantation development. Dev Cell (2004) 4.97

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks. Nat Cell Biol (2004) 4.87

Replicative senescence: the human fibroblast comes of age. Science (1990) 4.77

Asymmetric inheritance of mother versus daughter centrosome in stem cell division. Science (2007) 4.59

Histone variants--ancient wrap artists of the epigenome. Nat Rev Mol Cell Biol (2010) 4.45

Epigenetic inheritance during the cell cycle. Nat Rev Mol Cell Biol (2009) 4.43

Distribution and dynamics of chromatin modification induced by a defined DNA double-strand break. Curr Biol (2004) 4.35

Wdr5 mediates self-renewal and reprogramming via the embryonic stem cell core transcriptional network. Cell (2011) 4.04

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes. Genes Dev (1996) 3.70

Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks. J Cell Biol (2006) 3.63

GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis. Neuron (1995) 3.51

H2AX is required for chromatin remodeling and inactivation of sex chromosomes in male mouse meiosis. Dev Cell (2003) 3.42

BRCA1 tumour suppression occurs via heterochromatin-mediated silencing. Nature (2011) 3.30

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention. EMBO J (2004) 3.20

Nonsynaptic GABA signaling in postnatal subventricular zone controls proliferation of GFAP-expressing progenitors. Nat Neurosci (2005) 3.17

Chromatin connections to pluripotency and cellular reprogramming. Cell (2011) 3.07

Asymmetric centrosome inheritance maintains neural progenitors in the neocortex. Nature (2009) 3.03

BRCA1 is associated with a human SWI/SNF-related complex: linking chromatin remodeling to breast cancer. Cell (2000) 2.94

BRCA1, histone H2AX phosphorylation, and male meiotic sex chromosome inactivation. Curr Biol (2004) 2.67

Histone 2A, a heteromorphous family of eight protein species. Biochemistry (1980) 2.55

The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations. Proc Natl Acad Sci U S A (2004) 2.41

A role for a novel centrosome cycle in asymmetric cell division. J Cell Biol (2007) 2.40

Functionally unequal centrosomes drive spindle orientation in asymmetrically dividing Drosophila neural stem cells. Dev Cell (2007) 2.39

Double-strand-break-induced homologous recombination in mammalian cells. Biochem Soc Trans (2001) 2.36

DNA-SCARS: distinct nuclear structures that sustain damage-induced senescence growth arrest and inflammatory cytokine secretion. J Cell Sci (2010) 2.34

Histone H2AX-dependent GABA(A) receptor regulation of stem cell proliferation. Nature (2008) 2.24

H2AX may function as an anchor to hold broken chromosomal DNA ends in close proximity. Cell Cycle (2004) 2.16

ATM-dependent DNA damage-independent mitotic phosphorylation of H2AX in normally growing mammalian cells. Mol Biol Cell (2005) 2.13

FACT-mediated exchange of histone variant H2AX regulated by phosphorylation of H2AX and ADP-ribosylation of Spt16. Mol Cell (2008) 1.99

Factors associated with the mammalian RNA polymerase II holoenzyme. Nucleic Acids Res (1998) 1.93

DNA replication stress, genome instability and aging. Nucleic Acids Res (2007) 1.80

The nucleosome family: dynamic and growing. Structure (2009) 1.75

Phosphorylation of histone H2AX at M phase in human cells without DNA damage response. Biochem Biophys Res Commun (2005) 1.73

Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum Mol Genet (2001) 1.71

Histone ubiquitination and chromatin remodeling in mouse spermatogenesis. Dev Biol (1999) 1.60

BRCA1 participates in DNA decatenation. Nat Struct Mol Biol (2005) 1.59

DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J (2004) 1.58

Chromatin plasticity and genome organization in pluripotent embryonic stem cells. Curr Opin Cell Biol (2010) 1.54

MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev (2011) 1.52

Histone modifications and mitosis: countermarks, landmarks, and bookmarks. Trends Cell Biol (2012) 1.43

Nucleosome structure(s) and stability: variations on a theme. Annu Rev Biophys (2011) 1.43

The X as model for RNA's niche in epigenomic regulation. Cold Spring Harb Perspect Biol (2010) 1.43

Cell cycle restriction by histone H2AX limits proliferation of adult neural stem cells. Proc Natl Acad Sci U S A (2011) 1.41

Spreading of mammalian DNA-damage response factors studied by ChIP-chip at damaged telomeres. EMBO J (2007) 1.38

Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells. Exp Cell Res (2008) 1.24

Mad2 prolongs DNA damage checkpoint arrest caused by a double-strand break via a centromere-dependent mechanism. Curr Biol (2010) 1.20

Reinitiation of DNA synthesis and cell division in senescent human fibroblasts by microinjection of anti-p53 antibodies. Mol Cell Biol (1998) 1.19

DNA-PKcs plays a dominant role in the regulation of H2AX phosphorylation in response to DNA damage and cell cycle progression. BMC Mol Biol (2010) 1.19

The many tales of a tail: carboxyl-terminal tail heterogeneity specializes histone H2A variants for defined chromatin function. Biochemistry (2002) 1.19

DNA damage responses by human ELG1 in S phase are important to maintain genomic integrity. Cell Cycle (2009) 1.18

Chromatin remodeling underlies the senescence-associated secretory phenotype of tumor stromal fibroblasts that supports cancer progression. Cancer Res (2012) 1.17

Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice. Development (2010) 1.17

The association of ATR protein with mouse meiotic chromosome cores. Chromosoma (1999) 1.14

Biased segregation of DNA and centrosomes: moving together or drifting apart? Nat Rev Mol Cell Biol (2009) 1.11

Distribution of p53 binding protein 1 (53BP1) and phosphorylated H2A.X during mouse preimplantation development in the absence of DNA damage. Int J Dev Biol (2009) 1.11

Activation of DNA damage response signaling in mouse embryonic stem cells. Cell Cycle (2008) 1.08

M31 and macroH2A1.2 colocalise at the pseudoautosomal region during mouse meiosis. J Cell Sci (2001) 1.07

High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells. Stem Cells (2012) 1.07

Senescent human diploid cells in culture: survival, DNA synthesis and morphology. J Gerontol (1979) 1.05

A distinct H2A.X isoform is enriched in Xenopus laevis eggs and early embryos and is phosphorylated in the absence of a checkpoint. Proc Natl Acad Sci U S A (2009) 1.04

Phosphorylation of histone H2A.X by DNA-dependent protein kinase is not affected by core histone acetylation, but it alters nucleosome stability and histone H1 binding. J Biol Chem (2010) 1.02

γH2AX foci formation in the absence of DNA damage: mitotic H2AX phosphorylation is mediated by the DNA-PKcs/CHK2 pathway. FEBS Lett (2013) 1.01

Interplay between the DNA damage proteins MDC1 and ATM in the regulation of the spindle assembly checkpoint. J Biol Chem (2014) 0.99

The BRG1 ATPase of chromatin remodeling complexes is involved in modulation of mesenchymal stem cell senescence through RB-P53 pathways. Oncogene (2010) 0.96

Contribution of the serine 129 of histone H2A to chromatin structure. Mol Cell Biol (2007) 0.94

Nuclear organization and dosage compensation. Cold Spring Harb Perspect Biol (2010) 0.94

A maternal store of macroH2A is removed from pronuclei prior to onset of somatic macroH2A expression in preimplantation embryos. Dev Biol (2005) 0.94

BRCA1 associates with the inactive X chromosome in late S-phase, coupled with transient H2AX phosphorylation. Chromosoma (2005) 0.92

Barring gene expression after XIST: maintaining facultative heterochromatin on the inactive X. Semin Cell Dev Biol (2003) 0.91

Structure and function of histone H2AX. Subcell Biochem (2010) 0.90

Organizing the genome with H2A histone variants. Biochem J (2013) 0.90

Histone variant H2A.X deposition pattern serves as a functional epigenetic mark for distinguishing the developmental potentials of iPSCs. Cell Stem Cell (2014) 0.89

Capturing epigenetic dynamics during pre-implantation development using live cell imaging. J Biochem (2008) 0.86