A Phase I/II Trial of BNC105P with Everolimus in Metastatic Renal Cell Carcinoma.

PubWeight™: 0.75‹?›

🔗 View Article (PMC 4526387)

Published in Clin Cancer Res on March 18, 2015

Authors

Sumanta Pal1, Arun Azad2, Shailender Bhatia3, Harry Drabkin4, Brian Costello5, John Sarantopoulos6, Ravindran Kanesvaran7, Richard Lauer8, Alexander Starodub9, Ralph Hauke10, Christopher J Sweeney11, Noah M Hahn12, Guru Sonpavde13, Stephen Richey14, Timothy Breen15, Gabriel Kremmidiotis16, Annabell Leske16, Elizabeth Doolin16, David C Bibby16, Jeremy Simpson16, Jose Iglesias16, Thomas Hutson17

Author Affiliations

1: City of Hope Medical Center, Duarte, California. spal@coh.org.
2: BC Cancer Agency, Vancouver, British Columbia, Canada.
3: University of Washington, Seattle, Washington.
4: Medical University of South Carolina, Charleston, South Carolina.
5: Mayo Clinic, Rochester, Minnesota.
6: University of Texas Health Science Center, San Antonio, Texas.
7: National Cancer Center, Singapore.
8: University of New Mexico Cancer Center, Albuquerque, New Mexico.
9: Indiana University Health Goshen Center for Cancer Care, Goshen, Indiana.
10: Nebraska Cancer Specialists/Nebraska Methodist Hospital, Omaha, Nebraska.
11: Dana-Farber Cancer Center, Boston, Massachusetts.
12: Sidney Kimmel Comprehensive Cancer Center, Baltimore, Maryland.
13: University of Alabama, Birmingham, Alabama.
14: Texas Oncology, Fort Worth, Texas.
15: Hoosier Cancer Research Network, Indianapolis, Indiana.
16: Bionomics, Thebarton, South Australia, Australia.
17: Charles A. Sammons Cancer Center, Baylor University Medical Center, Dallas, Texas.

Associated clinical trials:

Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025) | NCT01668784

A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma (METEOR) | NCT01865747

Articles cited by this

Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet (2008) 19.58

Comparative effectiveness of axitinib versus sorafenib in advanced renal cell carcinoma (AXIS): a randomised phase 3 trial. Lancet (2011) 12.13

Discovery and development of sorafenib: a multikinase inhibitor for treating cancer. Nat Rev Drug Discov (2006) 6.88

Phase I pharmacokinetic and pharmacodynamic study of the oral mammalian target of rapamycin inhibitor everolimus in patients with advanced solid tumors. J Clin Oncol (2008) 5.98

Randomized phase III trial of temsirolimus and bevacizumab versus interferon alfa and bevacizumab in metastatic renal cell carcinoma: INTORACT trial. J Clin Oncol (2013) 3.20

Nivolumab for Metastatic Renal Cell Carcinoma: Results of a Randomized Phase II Trial. J Clin Oncol (2014) 2.78

Increased expression of matrix metalloproteinases 2 and 9 and tissue inhibitors of metalloproteinases 1 and 2 correlate with poor prognostic variables in renal cell carcinoma. Clin Cancer Res (2001) 1.41

A phase I study of cabozantinib (XL184) in patients with renal cell cancer. Ann Oncol (2014) 1.33

Nanostring-based multigene assay to predict recurrence for gastric cancer patients after surgery. PLoS One (2014) 1.17

Expression levels of genes that regulate metastasis and angiogenesis correlate with advanced pathological stage of renal cell carcinoma. Am J Pathol (2001) 1.11

BNC105: a novel tubulin polymerization inhibitor that selectively disrupts tumor vasculature and displays single-agent antitumor efficacy. Mol Cancer Ther (2010) 1.04

A novel class of tubulin inhibitors that exhibit potent antiproliferation and in vitro vessel-disrupting activity. Cancer Chemother Pharmacol (2007) 0.91

Gene expression profiling using nanostring digital RNA counting to identify potential target antigens for melanoma immunotherapy. Clin Cancer Res (2013) 0.89

Angiogenesis in renal cell carcinoma: Evaluation of microvessel density, vascular endothelial growth factor and matrix metalloproteinases. Int J Urol (2002) 0.89

Possible prognostic and therapeutic significance of c-Kit expression, mast cell count and microvessel density in renal cell carcinoma. Int J Mol Sci (2014) 0.88

Clinical, pharmacodynamic, and pharmacokinetic evaluation of BNC105P: a phase I trial of a novel vascular disrupting agent and inhibitor of cancer cell proliferation. Clin Cancer Res (2011) 0.88

Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma. Urology (2006) 0.87

Vascular disruption in combination with mTOR inhibition in renal cell carcinoma. Mol Cancer Ther (2011) 0.87

Association of serum amyloid A protein and peptide fragments with prognosis in renal cancer. Br J Cancer (2010) 0.84

The vascular disrupting agent BNC105 potentiates the efficacy of VEGF and mTOR inhibitors in renal and breast cancer. Cancer Biol Ther (2014) 0.80

Soluble KIT correlates with clinical outcome in patients with metastatic breast cancer treated with sunitinib. J Transl Med (2012) 0.80

Sequence mutations of the substrate binding pocket of stem cell factor and multidrug resistance protein ABCG2 in renal cell cancer: a possible link to treatment resistance. Oncol Rep (2013) 0.78