Signalling thresholds and negative B-cell selection in acute lymphoblastic leukaemia.

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Published in Nature on March 23, 2015

Authors

Zhengshan Chen1, Seyedmehdi Shojaee1, Maike Buchner1, Huimin Geng1, Jae Woong Lee1, Lars Klemm1, Björn Titz2, Thomas G Graeber2, Eugene Park1, Ying Xim Tan3, Anne Satterthwaite4, Elisabeth Paietta5, Stephen P Hunger6, Cheryl L Willman7, Ari Melnick8, Mignon L Loh9, Jae U Jung10, John E Coligan11, Silvia Bolland12, Tak W Mak13, Andre Limnander14, Hassan Jumaa15, Michael Reth16, Arthur Weiss3, Clifford A Lowell1, Markus Müschen1

Author Affiliations

1: Department of Laboratory Medicine, University of California, San Francisco, California 94143, USA.
2: Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.
3: Rosalind Russell-Ephraim P. Engleman Medical Research Center for Arthritis, Division of Rheumatology, Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143, USA.
4: Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
5: Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10466, USA.
6: Division of Pediatric Oncology and Center for Childhood Cancer Research, Children's Hospital of Philadelphia, Philadelphia, Philadelphia 19104, USA.
7: University of New Mexico Cancer Center, Albuquerque, New Mexico 87102, USA.
8: Departments of Medicine and Pharmacology, Weill Cornell Medical College, New York, New York 10065, USA.
9: Pediatric Hematology-Oncology, University of California, San Francisco, California 94143, USA.
10: Department of Molecular Microbiology and Immunology, University of Southern California, Los Angeles, California 90033, USA.
11: Receptor Cell Biology Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
12: Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland 20852, USA.
13: The Campbell Family Institute for Breast Cancer Research, University Health Network, 620 University Avenue, Toronto, Ontario M5G 2M9, Canada.
14: Department of Anatomy, University of California, San Francisco, California 94143, USA.
15: Institute of Immunology, University Clinics Ulm, 89081 Ulm, Germany.
16: BIOSS Centre for Biological Signalling Studies and Faculty of Biology, Albert-Ludwigs-Universität Freiburg, and MPI of Immunbiologie and Epigenetics, 79104 Freiburg, Germany.

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