Published in Crit Care Med on August 01, 2015
Impact of Drug Resistance on Virulence and Fitness of Bacterial Pathogens. Crit Care Med (2016) 1.05
Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis. Crit Care Med (2017) 0.76
The authors reply. Crit Care Med (2016) 0.75
The authors reply. Crit Care Med (2016) 0.75
Does Appropriate Antibiotic Therapy Mean Only Adequate Spectrum and Timing? Crit Care Med (2015) 0.75
Augmented renal clearance is not a risk factor for mortality in Enterobacteriaceae bloodstream infections treated with appropriate empiric antimicrobials. PLoS One (2017) 0.75
APACHE II: a severity of disease classification system. Crit Care Med (1985) 69.83
Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med (2006) 23.62
Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clin Microbiol Infect (2011) 17.47
National Nosocomial Infections Surveillance (NNIS) System Report, data summary from January 1992 through June 2004, issued October 2004. Am J Infect Control (2004) 14.85
The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest (2000) 9.51
Inadequate antimicrobial treatment of infections: a risk factor for hospital mortality among critically ill patients. Chest (1999) 7.40
Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest (2002) 3.98
Antibiotic therapy for Klebsiella pneumoniae bacteremia: implications of production of extended-spectrum beta-lactamases. Clin Infect Dis (2004) 3.75
Influx of extended-spectrum beta-lactamase-producing enterobacteriaceae into the hospital. Clin Infect Dis (2006) 3.64
Mortality and delay in effective therapy associated with extended-spectrum beta-lactamase production in Enterobacteriaceae bacteraemia: a systematic review and meta-analysis. J Antimicrob Chemother (2007) 3.55
Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother (2005) 3.49
Clinical and economic impact of bacteremia with extended- spectrum-beta-lactamase-producing Enterobacteriaceae. Antimicrob Agents Chemother (2006) 3.33
Occurrence and characterization of carbapenemase-producing Enterobacteriaceae: report from the SENTRY Antimicrobial Surveillance Program (2000-2004). Microb Drug Resist (2006) 3.11
Systematic review and meta-analysis of the efficacy of appropriate empiric antibiotic therapy for sepsis. Antimicrob Agents Chemother (2010) 2.34
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay. Crit Care Med (2011) 2.16
Survival in neutropenic patients with severe sepsis or septic shock. Crit Care Med (2012) 2.15
Current epidemiology and growing resistance of gram-negative pathogens. Korean J Intern Med (2012) 2.09
Association between source of infection and hospital mortality in patients who have septic shock. Am J Respir Crit Care Med (2014) 2.05
Nosocomial bacteremia caused by antibiotic-resistant gram-negative bacteria in critically ill patients: clinical outcome and length of hospitalization. Clin Infect Dis (2002) 1.88
Broad-spectrum antimicrobials and the treatment of serious bacterial infections: getting it right up front. Clin Infect Dis (2008) 1.79
The determinants of hospital mortality among patients with septic shock receiving appropriate initial antibiotic treatment*. Crit Care Med (2012) 1.78
Identifying critically ill patients at risk for inappropriate antibiotic therapy: a pilot study of a point-of-care decision support alert. Crit Care Med (2014) 1.60
Multicenter, double-blind, randomized, phase II trial to assess the safety and efficacy of ceftolozane-tazobactam plus metronidazole compared with meropenem in adult patients with complicated intra-abdominal infections. Antimicrob Agents Chemother (2014) 1.29
Multi-drug resistance, inappropriate initial antibiotic therapy and mortality in Gram-negative severe sepsis and septic shock: a retrospective cohort study. Crit Care (2014) 1.26
Clinical characteristics and risk factors for attributable mortality in Enterobacter cloacae bacteremia. J Microbiol Immunol Infect (2006) 1.07
A phase 3 randomized double-blind comparison of ceftobiprole medocaril versus ceftazidime plus linezolid for the treatment of hospital-acquired pneumonia. Clin Infect Dis (2014) 1.01
Epidemiology and clinical outcomes of bloodstream infections caused by extended-spectrum β-lactamase-producing Escherichia coli in patients with cancer. Int J Antimicrob Agents (2013) 0.99
Integration of technology into clinical practice. Clin Lab Med (2013) 0.99
Extended spectrum β-lactamase producers among nosocomial Enterobacteriaceae in Latin America. Braz J Infect Dis (2014) 0.99
Predictors of hospital mortality for patients with severe sepsis treated with Drotrecogin alfa (activated). Pharmacotherapy (2005) 0.98
Impact of antimicrobial resistance on the treatment and outcome of patients with sepsis. Shock (2008) 0.94
Current and future treatment options for infections caused by multidrug-resistant Gram-negative pathogens. Future Microbiol (2014) 0.85
Linezolid in methicillin-resistant Staphylococcus aureus nosocomial pneumonia: a randomized, controlled study. Clin Infect Dis (2012) 7.97
Epidemiology and outcomes of ventilator-associated pneumonia in a large US database. Chest (2002) 6.13
Linezolid vs vancomycin: analysis of two double-blind studies of patients with methicillin-resistant Staphylococcus aureus nosocomial pneumonia. Chest (2003) 5.64
Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality. Antimicrob Agents Chemother (2005) 5.35
Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med (2006) 4.10
Clinical importance of delays in the initiation of appropriate antibiotic treatment for ventilator-associated pneumonia. Chest (2002) 3.98
Increase in adult Clostridium difficile-related hospitalizations and case-fatality rate, United States, 2000-2005. Emerg Infect Dis (2008) 3.88
Validation of a clinical score for assessing the risk of resistant pathogens in patients with pneumonia presenting to the emergency department. Clin Infect Dis (2011) 3.78
The epidemiology, pathogenesis and treatment of Pseudomonas aeruginosa infections. Drugs (2007) 3.63
Pseudomonas aeruginosa bloodstream infection: importance of appropriate initial antimicrobial treatment. Antimicrob Agents Chemother (2005) 3.49
Telavancin versus vancomycin for hospital-acquired pneumonia due to gram-positive pathogens. Clin Infect Dis (2011) 3.20
Pneumonia caused by methicillin-resistant Staphylococcus aureus. Clin Infect Dis (2008) 3.13
The importance of fluid management in acute lung injury secondary to septic shock. Chest (2009) 2.92
Time to Appropriate Antibiotic Therapy Is an Independent Determinant of Postinfection ICU and Hospital Lengths of Stay in Patients With Sepsis. Crit Care Med (2015) 2.86
Fluconazole prophylaxis in critically ill surgical patients: a meta-analysis. Crit Care Med (2005) 2.70
Outcome and attributable cost of ventilator-associated pneumonia among intensive care unit patients in a suburban medical center. Crit Care Med (2003) 2.59
Hospital-wide impact of a standardized order set for the management of bacteremic severe sepsis. Crit Care Med (2009) 2.57
Healthcare-associated bloodstream infection: A distinct entity? Insights from a large U.S. database. Crit Care Med (2006) 2.51
Health care-associated pneumonia and community-acquired pneumonia: a single-center experience. Antimicrob Agents Chemother (2007) 2.49
Implementation of a real-time computerized sepsis alert in nonintensive care unit patients. Crit Care Med (2011) 2.35
Short- vs long-duration antibiotic regimens for ventilator-associated pneumonia: a systematic review and meta-analysis. Chest (2013) 2.32
A randomized controlled trial of an antibiotic discontinuation policy for clinically suspected ventilator-associated pneumonia. Chest (2004) 2.26
Endotracheal tube intraluminal volume loss among mechanically ventilated patients. Crit Care Med (2004) 2.20
Inappropriate antibiotic therapy in Gram-negative sepsis increases hospital length of stay. Crit Care Med (2011) 2.16
Probiotic prophylaxis of ventilator-associated pneumonia: a blinded, randomized, controlled trial. Am J Respir Crit Care Med (2010) 2.15
Early versus late enteral feeding of mechanically ventilated patients: results of a clinical trial. JPEN J Parenter Enteral Nutr (2002) 2.15
Occurrence of co-colonization or co-infection with vancomycin-resistant enterococci and methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol (2004) 2.13
Association between a silver-coated endotracheal tube and reduced mortality in patients with ventilator-associated pneumonia. Chest (2009) 2.09
Pneumonia Pathogen Characterization Is an Independent Determinant of Hospital Readmission. Chest (2015) 2.09
Treatment-related risk factors for hospital mortality in Candida bloodstream infections. Crit Care Med (2008) 2.06
A retrospective analysis of possible renal toxicity associated with vancomycin in patients with health care-associated methicillin-resistant Staphylococcus aureus pneumonia. Clin Ther (2007) 2.05
Attitudes of respiratory therapists and nurses about measures to prevent ventilator-associated pneumonia: a multicenter, cross-sectional survey study. Respir Care (2007) 2.03
Delirium as detected by the CAM-ICU predicts restraint use among mechanically ventilated medical patients. Crit Care Med (2005) 1.92
Economic implications of an evidence-based sepsis protocol: can we improve outcomes and lower costs? Crit Care Med (2007) 1.88
Methicillin-resistant Staphylococcus aureus sterile-site infection: The importance of appropriate initial antimicrobial treatment. Crit Care Med (2006) 1.86
A comparison of ventilator-associated pneumonia rates as identified according to the National Healthcare Safety Network and American College of Chest Physicians criteria. Crit Care Med (2012) 1.82
Diagnostic implications of soluble triggering receptor expressed on myeloid cells-1 in BAL fluid of patients with pulmonary infiltrates in the ICU. Chest (2008) 1.81
Methicillin-resistant Staphylococcus aureus prolongs intensive care unit stay in ventilator-associated pneumonia, despite initially appropriate antibiotic therapy. Crit Care Med (2006) 1.80
Effect of an education program aimed at reducing the occurrence of ventilator-associated pneumonia. Crit Care Med (2002) 1.72
Inappropriate therapy for methicillin-resistant Staphylococcus aureus: resource utilization and cost implications. Crit Care Med (2008) 1.72
Antimicrobial stewardship in the intensive care unit: advances and obstacles. Am J Respir Crit Care Med (2009) 1.71
Silver-coated endotracheal tubes associated with reduced bacterial burden in the lungs of mechanically ventilated dogs. Chest (2002) 1.63
Use of adjunctive aerosolized antimicrobial therapy in the treatment of Pseudomonas aeruginosa and Acinetobacter baumannii ventilator-associated pneumonia. Respir Care (2012) 1.62
Clostridium difficile in the intensive care unit: epidemiology, costs, and colonization pressure. Infect Control Hosp Epidemiol (2007) 1.61
Nursing adherence with evidence-based guidelines for preventing ventilator-associated pneumonia. Crit Care Med (2003) 1.61
Identifying critically ill patients at risk for inappropriate antibiotic therapy: a pilot study of a point-of-care decision support alert. Crit Care Med (2014) 1.60
Readmission following hospitalization for pneumonia: the impact of pneumonia type and its implication for hospitals. Clin Infect Dis (2013) 1.60
A prospective evaluation of ventilator-associated conditions and infection-related ventilator-associated conditions. Chest (2015) 1.59
Prediction of infection due to antibiotic-resistant bacteria by select risk factors for health care-associated pneumonia. Arch Intern Med (2008) 1.58
Tracheobronchial aspiration of gastric contents in critically ill tube-fed patients: frequency, outcomes, and risk factors. Crit Care Med (2006) 1.57
Use of a handheld computer by respiratory care practitioners to improve the efficiency of weaning patients from mechanical ventilation. Crit Care Med (2002) 1.56
Patient safety event reporting in critical care: a study of three intensive care units. Crit Care Med (2007) 1.51
A randomized trial of conventional chest physical therapy versus high frequency chest wall compressions in intubated and non-intubated adults. Respir Care (2011) 1.51
Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med (2004) 1.49
Antimicrobial therapy escalation and hospital mortality among patients with health-care-associated pneumonia: a single-center experience. Chest (2008) 1.47
Epidemiology and outcomes of clostridium difficile-associated disease among patients on prolonged acute mechanical ventilation. Chest (2009) 1.47
Non-invasive stroke volume measurement and passive leg raising predict volume responsiveness in medical ICU patients: an observational cohort study. Crit Care (2009) 1.47
Physicians' estimates of cardiac index and intravascular volume based on clinical assessment versus transesophageal Doppler measurements obtained by critical care nurses. Am J Crit Care (2003) 1.46
Hospital mortality for patients with bacteremia due to Staphylococcus aureus or Pseudomonas aeruginosa. Chest (2004) 1.45
Diagnostic utility of plasma procalcitonin for nosocomial pneumonia in the intensive care unit setting. Respir Care (2011) 1.45
Prevention of hospital infection. Microbes Infect (2005) 1.45
Activity of a silver-coated endotracheal tube in preclinical models of ventilator-associated pneumonia and a study after extubation. Crit Care Med (2010) 1.42
Secular trends in candidemia-related hospitalization in the United States, 2000-2005. Infect Control Hosp Epidemiol (2008) 1.42
Ambulatory care-sensitive conditions: clinical outcomes and impact on intensive care unit resource use. South Med J (2003) 1.42
Levofloxacin for treatment of ventilator-associated pneumonia: a subgroup analysis from a randomized trial. Clin Infect Dis (2005) 1.40
Addition of vasopressin to norepinephrine as independent predictor of mortality in patients with refractory septic shock: an observational study. Surg Infect (Larchmt) (2007) 1.39
Morbidity and cost burden of methicillin-resistant Staphylococcus aureus in early onset ventilator-associated pneumonia. Crit Care (2006) 1.37
Staphylococcus aureus nasal colonization and subsequent infection in intensive care unit patients: does methicillin resistance matter? Infect Control Hosp Epidemiol (2010) 1.34
Cost and mortality prediction using polymerase chain reaction pathogen detection in sepsis: evidence from three observational trials. Crit Care (2010) 1.33
Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia. Clin Ther (2003) 1.33
Analysis of 30-day mortality for clostridium difficile-associated disease in the ICU setting. Chest (2007) 1.30
Inappropriate empiric antifungal therapy for candidemia in the ICU and hospital resource utilization: a retrospective cohort study. BMC Infect Dis (2010) 1.29
Empiric combination antibiotic therapy is associated with improved outcome against sepsis due to Gram-negative bacteria: a retrospective analysis. Antimicrob Agents Chemother (2010) 1.27
Hospital resource utilization and costs of inappropriate treatment of candidemia. Pharmacotherapy (2010) 1.25
Deep vein thrombosis during prolonged mechanical ventilation despite prophylaxis. Crit Care Med (2002) 1.25
The effect of an education program on the incidence of central venous catheter-associated bloodstream infection in a medical ICU. Chest (2004) 1.24
Increase in Clostridium difficile-related hospitalizations among infants in the United States, 2000-2005. Pediatr Infect Dis J (2008) 1.20
Transfusion practice and blood stream infections in critically ill patients. Chest (2005) 1.19
A randomized trial of 7-day doripenem versus 10-day imipenem-cilastatin for ventilator-associated pneumonia. Crit Care (2012) 1.18
An educational intervention to reduce ventilator-associated pneumonia in an integrated health system: a comparison of effects. Chest (2004) 1.16
Red blood cell transfusion and ventilator-associated pneumonia: A potential link? Crit Care Med (2004) 1.15
Fluid balance and cardiac function in septic shock as predictors of hospital mortality. Crit Care (2013) 1.14
Invasive approaches to the diagnosis of ventilator-associated pneumonia: a meta-analysis. Crit Care Med (2005) 1.13
Risk factors for ventilator-associated pneumonia: from epidemiology to patient management. Clin Infect Dis (2004) 1.13
Reporting of medical errors: an intensive care unit experience. Crit Care Med (2004) 1.13
Early prediction of septic shock in hospitalized patients. J Hosp Med (2010) 1.12
Growth and geographic variation in hospitalizations with resistant infections, United States, 2000-2005. Emerg Infect Dis (2008) 1.10
Hypoglossal neuropathology and respiratory activity in pompe mice. Front Physiol (2011) 1.10
Probiotics for preventing and treating nosocomial infections: review of current evidence and recommendations. Chest (2007) 1.09
Cycling empirical antimicrobial agents to prevent emergence of antimicrobial-resistant Gram-negative bacteria among intensive care unit patients. Crit Care Med (2004) 1.09
A comparison of culture-positive and culture-negative health-care-associated pneumonia. Chest (2009) 1.07
A trial of a real-time alert for clinical deterioration in patients hospitalized on general medical wards. J Hosp Med (2013) 1.06
Economic burden of ventilator-associated pneumonia based on total resource utilization. Infect Control Hosp Epidemiol (2010) 1.05
Do clinical features allow for accurate prediction of fungal pathogenesis in bloodstream infections? Potential implications of the increasing prevalence of non-albicans candidemia. Crit Care Med (2007) 1.05