Prospective validation of a 1-hour algorithm to rule-out and rule-in acute myocardial infarction using a high-sensitivity cardiac troponin T assay.

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Published in CMAJ on April 13, 2015

Authors

Tobias Reichlin1, Raphael Twerenbold1, Karin Wildi1, Maria Rubini Gimenez1, Nathalie Bergsma1, Philip Haaf1, Sophie Druey1, Christian Puelacher1, Berit Moehring1, Michael Freese1, Claudia Stelzig1, Lian Krivoshei1, Petra Hillinger1, Cedric Jäger1, Thomas Herrmann1, Philip Kreutzinger1, Milos Radosavac1, Zoraida Moreno Weidmann1, Kateryna Pershyna1, Ursina Honegger1, Max Wagener1, Thierry Vuillomenet1, Isabel Campodarve1, Roland Bingisser1, Òscar Miró1, Katharina Rentsch1, Stefano Bassetti1, Stefan Osswald1, Christian Mueller2

Author Affiliations

1: Department of Cardiology and Cardiovascular Research Institute Basel (Reichlin, Twerenbold, Wildi, Rubini Gimenez, Bergsma, Haaf, Druey, Puelacher, Moehring, Freese, Stelzig, Krivoshei, Hillinger, Jäger, Herrmann, Kreutzinger, Radosavac, Weidmann, Pershyna, Honegger, Wagener, Vuillomenet, Osswald, Mueller), Universitätsspital Basel, Basel, Switzerland; Emergency Department (Rubini Gimenez, Campodarve), Internal Medicine Department, Hospital del Mar - Institut Municipal d'Investigació Mèdica, Barcelona, Spain; Emergency Department (Bingisser), Universitätsspital Basel, Basel, Switzerland; Emergency Department (Miró), Hospital Clínic de Barcelona, Barcelona, Spain; Laboratory Medicine (Rentsch), Universitätsspital Basel, Basel, Switzerland; Kantonsspital Olten (Bassetti), Olten, Switzerland.
2: Department of Cardiology and Cardiovascular Research Institute Basel (Reichlin, Twerenbold, Wildi, Rubini Gimenez, Bergsma, Haaf, Druey, Puelacher, Moehring, Freese, Stelzig, Krivoshei, Hillinger, Jäger, Herrmann, Kreutzinger, Radosavac, Weidmann, Pershyna, Honegger, Wagener, Vuillomenet, Osswald, Mueller), Universitätsspital Basel, Basel, Switzerland; Emergency Department (Rubini Gimenez, Campodarve), Internal Medicine Department, Hospital del Mar - Institut Municipal d'Investigació Mèdica, Barcelona, Spain; Emergency Department (Bingisser), Universitätsspital Basel, Basel, Switzerland; Emergency Department (Miró), Hospital Clínic de Barcelona, Barcelona, Spain; Laboratory Medicine (Rentsch), Universitätsspital Basel, Basel, Switzerland; Kantonsspital Olten (Bassetti), Olten, Switzerland chmueller@uhbs.ch.

Associated clinical trials:

Advantageous Predictors of Acute Coronary Syndromes Evaluation (APACE) Study (APACE) | NCT00470587

Trial of Cardiac CT in Acute Chest Patients With Intermediate Level Initial High-sensitivity Cardiac Troponin (PROTECCT) | NCT03583320

Rapid Use of High-sensitive Cardiac Troponin I for ruling-in and Ruling-out of Acute Myocardial Infarction (RACING-MI) | NCT03634384

Early Cardiac Magnetic Resonance Imaging in Suspected Non-ST-Elevation Myocardial Infarction (CMR-OBSERVE) | NCT04140019

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