Direct venous inoculation of Plasmodium falciparum sporozoites for controlled human malaria infection: a dose-finding trial in two centres.

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Published in Malar J on March 18, 2015

Authors

Benjamin Mordmüller1, Christian Supan2, Kim Lee Sim3, Gloria P Gómez-Pérez4, Carmen Lucelly Ospina Salazar5, Jana Held6, Stefanie Bolte7, Meral Esen8, Serena Tschan9, Fanny Joanny10, Carlos Lamsfus Calle11, Sascha J Z Löhr12, Albert Lalremruata13, Anusha Gunasekera14, Eric R James15, Peter F Billingsley16, Adam Richman17, Sumana Chakravarty18, Almudena Legarda19, Jose Muñoz20, Rosa M Antonijoan21,22, Maria Rosa Ballester23,24, Stephen L Hoffman25, Pedro L Alonso26, Peter G Kremsner27

Author Affiliations

1: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. benjamin.mordmueller@uni-tuebingen.de.
2: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. christian.supan@medizin.uni-tuebingen.de.
3: Sanaria Inc, Rockville, MD, 20850, USA. ksim@protpot.com.
4: Barcelona Center for International Health Research (CRESIB), Hospital Clínic, University of Barcelona, E-08036, Barcelona, Spain. patricia.gomez@cresib.cat.
5: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. carmenlucelly@hotmail.com.
6: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. janaheld@hotmail.de.
7: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. stefanie.bolte@web.de.
8: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. meral.esen@uni-tuebingen.de.
9: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. serena.tschan@gmail.com.
10: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. fanny.joanny@gmail.com.
11: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. carlos.lamsfus@gmail.com.
12: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. sascha-zori-loehr@web.de.
13: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. albrt.04@gmail.com.
14: Sanaria Inc, Rockville, MD, 20850, USA. agunasekera@sanaria.com.
15: Sanaria Inc, Rockville, MD, 20850, USA. ejames@sanaria.com.
16: Sanaria Inc, Rockville, MD, 20850, USA. pbillingsley@sanaria.com.
17: Sanaria Inc, Rockville, MD, 20850, USA. arichman@sanaria.com.
18: Sanaria Inc, Rockville, MD, 20850, USA. schakravarty@sanaria.com.
19: Barcelona Center for International Health Research (CRESIB), Hospital Clínic, University of Barcelona, E-08036, Barcelona, Spain. almudena.legarda@gmail.com.
20: Barcelona Center for International Health Research (CRESIB), Hospital Clínic, University of Barcelona, E-08036, Barcelona, Spain. jmunozg@clinic.ub.es.
21: Drug Research Center (CIM), Institute of Biomedical Research (IIB), Research Institute of Santa Creu and Sant Pau Hospital, Barcelona, Spain. rantonijoana@santpau.cat.
22: Department of Pharmacology and Therapeutics, Autonomous University of Barcelona (UAB), Santa Creu and Sant Pau Hospital, E-08026, Barcelona, Spain. rantonijoana@santpau.cat.
23: Drug Research Center (CIM), Institute of Biomedical Research (IIB), Research Institute of Santa Creu and Sant Pau Hospital, Barcelona, Spain. mballesterv@santpau.cat.
24: Department of Pharmacology and Therapeutics, Autonomous University of Barcelona (UAB), Santa Creu and Sant Pau Hospital, E-08026, Barcelona, Spain. mballesterv@santpau.cat.
25: Sanaria Inc, Rockville, MD, 20850, USA. slhoffman@sanaria.com.
26: Barcelona Center for International Health Research (CRESIB), Hospital Clínic, University of Barcelona, E-08036, Barcelona, Spain. pedro.alonso@isglobal.org.
27: Institut für Tropenmedizin, Eberhard Karls Universität Tübingen and German Center for Infection Research, 72074, Tübingen, Germany. peter.kremsner@uni-tuebingen.de.

Associated clinical trials:

Controlled Human Malarial Infection by Intravenous Injection of Plasmodium Falciparum Sporozoites in Non-Immune Adults | NCT01624961

Optimization of Controlled Human Malarial Infection by Injection of P. Falciparum Sporozoites in Non-Immune Adults | NCT01771848

Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis | NCT02115516

Safety, Immunogenicity, and Protective Efficacy of Radiation Attenuated Plasmodium Falciparum NF54 Sporozoites (PfSPZ Vaccine) in Healthy African Adults in Mali | NCT02627456

Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Trial to Determine Safety and Development of Protective Efficacy After Exposure to Only Pre-erythrocytic Stages of Plasmodium Falciparum | NCT03083847

Chemoprotective Activity of MMV390048 in PfSPZ Challenge Model | NCT03195387

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