Pilot Trial of FANG Immunotherapy in Ewing's Sarcoma.

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Published in Mol Ther on March 19, 2015

Authors

Maurizio Ghisoli1, Minal Barve2, Reva Schneider3, Robert Mennel4, Carl Lenarsky5, Gladice Wallraven6, Beena O Pappen6, John LaNoue7, Padmasini Kumar6, Derek Nemunaitis8, Alyssa Roth8, James Nemunaitis8, Sam Whiting6, Neil Senzer9, Frederick A Fletcher6, John Nemunaitis10

Author Affiliations

1: Mary Crowley Cancer Research Centers, Dallas, Texas, USA; Texas Oncology, P.A., Dallas, Texas, USA; Medical City Dallas Hospital, Dallas, Texas, USA.
2: Mary Crowley Cancer Research Centers, Dallas, Texas, USA; Texas Oncology, P.A., Dallas, Texas, USA.
3: Mary Crowley Cancer Research Centers, Dallas, Texas, USA; Texas Oncology, P.A., Dallas, Texas, USA; Gradalis, Inc., Dallas, Texas, USA.
4: Texas Oncology, P.A., Dallas, Texas, USA; Baylor University Medical Center, Dallas, Texas, USA.
5: Texas Oncology, P.A., Dallas, Texas, USA; Medical City Dallas Hospital, Dallas, Texas, USA.
6: Gradalis, Inc., Dallas, Texas, USA.
7: Medical City Children's Hospital, Dallas, Texas, USA.
8: Mary Crowley Cancer Research Centers, Dallas, Texas, USA.
9: Mary Crowley Cancer Research Centers, Dallas, Texas, USA; Gradalis, Inc., Dallas, Texas, USA.
10: Mary Crowley Cancer Research Centers, Dallas, Texas, USA; Texas Oncology, P.A., Dallas, Texas, USA; Gradalis, Inc., Dallas, Texas, USA; Medical City Dallas Hospital, Dallas, Texas, USA. Electronic address: jnemunaitis@marycrowley.org.

Associated clinical trials:

Trial of Adjuvant FANG™ Vaccine for High Risk Stage III/IV Ovarian Cancer (FANG Ovarian) | NCT01309230

Randomized Phase II Adjuvant Chemotherapy ± FANG™ in Colorectal Carcinoma With Liver Metastases (FANG-CLM) | NCT01505166

Vigil™ + Nivolumab in Advanced Non-Small Cell Lung Cancer | NCT02639234

Phase II/III Trial of Maintenance Vigil™ for High Risk Stage III/IV Ovarian Cancer (VITAL) | NCT02346747

Pilot Study of Vigil™ + Pembrolizumab for Advanced Melanoma | NCT02574533

Randomized Phase IIb Trial of Vigil™ Versus Gemcitabine + Docetaxel for Ewing's Sarcoma | NCT02511132

Trial of Atezolizumab and Vigil for Advanced Gynecological Cancers (A Companion Study to CL-PTL-119) | NCT03073525

Vigil + Irinotecan and Temozolomide in Ewing's Sarcoma (VITA) | NCT03495921

Expanded Access of Vigil in Solid Tumors | NCT03842865

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