Published in Proc Natl Acad Sci U S A on December 01, 1989
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Identification of Mycobacterium tuberculosis DNA in a pre-Columbian Peruvian mummy. Proc Natl Acad Sci U S A (1994) 3.12
Detection of Babesia microti by polymerase chain reaction. J Clin Microbiol (1992) 3.03
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Fidelity of DNA synthesis by the Thermococcus litoralis DNA polymerase--an extremely heat stable enzyme with proofreading activity. Nucleic Acids Res (1991) 1.83
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RNA editing and regulation of Drosophila 4f-rnp expression by sas-10 antisense readthrough mRNA transcripts. RNA (2003) 1.70
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Mutations of the microsomal triglyceride-transfer-protein gene in abetalipoproteinemia. Am J Hum Genet (1995) 1.47
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Heterogeneity and evolution rates of delta virus RNA sequences. J Virol (1990) 1.45
Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational analysis. Nucleic Acids Res (1994) 1.39
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Removal of polymerase-produced mutant sequences from PCR products. Proc Natl Acad Sci U S A (1997) 1.34
Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence. Genome Res (1997) 1.34
Autosomal recessive chronic granulomatous disease caused by deletion at a dinucleotide repeat. Proc Natl Acad Sci U S A (1991) 1.28
Molecular cloning of a human melanoma-associated chondroitin sulfate proteoglycan. Proc Natl Acad Sci U S A (1996) 1.25
A fetally expressed immunoglobulin VH1 gene belongs to a complex set of alleles. J Clin Invest (1993) 1.25
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Measuring cation dependent DNA polymerase fidelity landscapes by deep sequencing. PLoS One (2012) 1.20
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A general method for cloning recA genes of gram-positive bacteria by polymerase chain reaction. J Bacteriol (1992) 1.14
A PCR procedure to determine the sequence of large polypeptides by rapid walking through a cDNA library. Proc Natl Acad Sci U S A (1991) 1.13
Ongoing diversification of the rearranged immunoglobulin light-chain gene in a bursal lymphoma cell line. Mol Cell Biol (1990) 1.11
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Activation of the c-Ki-ras oncogene in aflatoxin B1-induced hepatocellular carcinoma and adenoma in the rat: detection by denaturing gradient gel electrophoresis. Proc Natl Acad Sci U S A (1993) 1.04
Expanding the structural and functional diversity of RNA: analog uridine triphosphates as candidates for in vitro selection of nucleic acids. Nucleic Acids Res (2000) 1.04
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Tracing the development of single memory-lineage B cells in a highly defined immune response. J Exp Med (1996) 1.03
General primer polymerase chain reaction in combination with sequence analysis for identification of potentially novel human papillomavirus genotypes in cervical lesions. J Clin Microbiol (1992) 1.03
Genetic stability of foamy viruses: long-term study in an African green monkey population. J Virol (1999) 1.03
Evidence that specific mtDNA point mutations may not accumulate in skeletal muscle during normal human aging. Am J Hum Genet (1996) 1.02
Autoaggressive myocytotoxic T lymphocytes expressing an unusual gamma/delta T cell receptor. J Exp Med (1992) 1.01
High fidelity TNA synthesis by Therminator polymerase. Nucleic Acids Res (2005) 1.01
Isothermal amplification methods for the detection of nucleic acids in microfluidic devices. Biosensors (Basel) (2012) 1.01
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PCR-based ordered genomic libraries: a new approach to drug target identification for Streptococcus pneumoniae. Antimicrob Agents Chemother (2002) 0.99
A double mutation in exon 6 of the beta-hexosaminidase alpha subunit in a patient with the B1 variant of Tay-Sachs disease. Am J Hum Genet (1992) 0.98
Nucleotide sequence analysis of Aleutian mink disease parvovirus shows that multiple virus types are present in infected mink. J Virol (1991) 0.98
Importance of basic residues in binding of rous sarcoma virus nucleocapsid to the RNA packaging signal. J Virol (2003) 0.97
Expression in Escherichia coli and sequencing of the coding region for the capsid protein of Dutch maedi-visna virus strain ZZV 1050: application of recombinant protein in enzyme-linked immunosorbent assay for the detection of caprine and ovine lentiviruses. J Clin Microbiol (1991) 0.97
Polymerase chain reaction-mediated gene synthesis: synthesis of a gene coding for isozyme c of horseradish peroxidase. Proc Natl Acad Sci U S A (1991) 0.93
RNA editing of hepatitis B virus transcripts by activation-induced cytidine deaminase. Proc Natl Acad Sci U S A (2013) 0.92
A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. Nucleic Acids Res (2000) 0.91
Sources of PCR-induced distortions in high-throughput sequencing data sets. Nucleic Acids Res (2015) 0.90
Next-generation sequencing reveals how RNA catalysts evolve from random space. Nucleic Acids Res (2013) 0.90
A mutant allele common to the type I adenine phosphoribosyltransferase deficiency in Japanese subjects. Am J Hum Genet (1991) 0.89
Restricted use of fetal VH3 immunoglobulin genes by unselected B cells in the adult. Predominance of 56p1-like VH genes in common variable immunodeficiency. J Clin Invest (1992) 0.88
Genotypic analysis of mutations in Taq I restriction recognition sites by restriction fragment length polymorphism/polymerase chain reaction. Proc Natl Acad Sci U S A (1992) 0.88
Microsatellite instability in preinvasive and invasive head and neck squamous carcinoma. Am J Pathol (1996) 0.88
Novel amplification of DNA in a hairpin structure: towards a radical elimination of PCR errors from amplified DNA. Nucleic Acids Res (2003) 0.87
Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplification. Proc Natl Acad Sci U S A (1992) 0.87
Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. Proc Natl Acad Sci U S A (1991) 0.87
Yeast three-hybrid screening of rous sarcoma virus mutants with randomly mutagenized minimal packaging signals reveals regions important for gag interactions. J Virol (2000) 0.86
Improved multiple displacement amplification (iMDA) and ultraclean reagents. BMC Genomics (2014) 0.86
Microsatellite alteration at chromosome 3p loci in neuroendocrine and non-neuroendocrine lung tumors. Histogenetic and clinical relevance. Am J Pathol (1996) 0.86
Extensive Mitochondrial Heteroplasmy in Natural Populations of a Resurging Human Pest, the Bed Bug (Hemiptera: Cimicidae). J Med Entomol (2015) 0.85
High-throughput discovery of mutations in tef semi-dwarfing genes by next-generation sequencing analysis. Genetics (2012) 0.85
Both mutated and unmutated memory B cells accumulate mutations in the course of the secondary response and develop a new antibody repertoire optimally adapted to the secondary stimulus. Int Immunol (2013) 0.84
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Analysis of mutational spectra by denaturing capillary electrophoresis. Nat Protoc (2008) 0.84
Uncovering Wolbachia diversity upon artificial host transfer. PLoS One (2013) 0.83
Description of an unusual Neisseria meningitidis isolate containing and expressing Neisseria gonorrhoeae-Specific 16S rRNA gene sequences. J Clin Microbiol (2013) 0.83
Isolation and characterization of a variant dihydrofolate reductase cDNA from methotrexate-resistant murine L5178Y cells. Nucleic Acids Res (1990) 0.83
The spontaneous replication error and the mismatch discrimination mechanisms of human DNA polymerase β. Nucleic Acids Res (2014) 0.82
Multiplex assay for species identification and monitoring of insecticide resistance in Anopheles punctulatus group populations of Papua New Guinea. Am J Trop Med Hyg (2012) 0.82
Investigation into the annotation of protocol sequencing steps in the sequence read archive. Gigascience (2015) 0.82
The Core/E1 domain of hepatitis C virus genotype 4a in Egypt does not contain viral mutations or strains specific for hepatocellular carcinoma. J Clin Virol (2011) 0.81
Non-phenotypic selection of N-methyl-N-nitrosourea-induced mutations in human cells. Nucleic Acids Res (1992) 0.81
Efficiency of the Polymerase Chain Reaction. Chem Eng Sci (2010) 0.81
Estimating genetic variability in non-model taxa: a general procedure for discriminating sequence errors from actual variation. PLoS One (2010) 0.80
Strategy for cloning large gene assemblages as illustrated using the phenylacetate and polyhydroxyalkanoate gene clusters. Appl Environ Microbiol (2004) 0.79
Determining lower limits of detection of digital PCR assays for cancer-related gene mutations. Biomol Detect Quantif (2014) 0.78
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PCR performance of the B-type DNA polymerase from the thermophilic euryarchaeon Thermococcus aggregans improved by mutations in the Y-GG/A motif. Nucleic Acids Res (2000) 0.78
Limitations and challenges of genetic barcode quantification. Sci Rep (2017) 0.78
Differences in mutagenesis during minus strand, plus strand and strand transfer (recombination) synthesis of the HIV-1 gene in vitro. Nucleic Acids Res (1996) 0.77
Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science (1988) 220.77
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08
Specific synthesis of DNA in vitro via a polymerase-catalyzed chain reaction. Methods Enzymol (1987) 58.68
DNA sequence analysis with a modified bacteriophage T7 DNA polymerase. Proc Natl Acad Sci U S A (1987) 37.15
Direct cloning and sequence analysis of enzymatically amplified genomic sequences. Science (1986) 19.54
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Length mutations in human mitochondrial DNA: direct sequencing of enzymatically amplified DNA. Nucleic Acids Res (1987) 10.38
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Characterization of beta-thalassaemia mutations using direct genomic sequencing of amplified single copy DNA. Nature (1987) 8.58
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Fidelity of DNA synthesis. Annu Rev Biochem (1982) 6.54
Detection of single base substitutions in total genomic DNA. Nature (1985) 5.99
Computational simulation of DNA melting and its application to denaturing gradient gel electrophoresis. Methods Enzymol (1987) 4.50
Escherichia coli thioredoxin confers processivity on the DNA polymerase activity of the gene 5 protein of bacteriophage T7. J Biol Chem (1987) 4.21
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Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich. Am J Hum Genet (1988) 3.50
Organization of the HPRT gene and related sequences in the human genome. Somat Cell Mol Genet (1984) 2.84
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DNA amplification in vitro using T4 DNA polymerase. DNA (1988) 2.45
Characterization of c-Ki-ras oncogene alleles by direct sequencing of enzymatically amplified DNA from carcinogen-induced tumors. Proc Natl Acad Sci U S A (1987) 1.98
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Detection of human DNA polymorphisms with a simplified denaturing gradient gel electrophoresis technique. Proc Natl Acad Sci U S A (1987) 1.68
On the fidelity of DNA replication. The accuracy of T4 DNA polymerases in copying phi X174 DNA in vitro. J Biol Chem (1984) 1.65
Enzymatic amplification and characterization of large DNA fragments from genomic DNA. Gene (1988) 1.02
Resolution of a missense mutant in human genomic DNA by denaturing gradient gel electrophoresis and direct sequencing using in vitro DNA amplification: HPRT Munich. Am J Hum Genet (1988) 3.50
Mismatch amplification mutation assay (MAMA): application to the c-H-ras gene. PCR Methods Appl (1992) 3.42
An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair. Proc Natl Acad Sci U S A (1993) 3.07
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Quantitative forward mutation assay in Salmonella typhimurium using 8-azaguanine resistance as a genetic marker. Proc Natl Acad Sci U S A (1978) 2.65
DNA amplification in vitro using T4 DNA polymerase. DNA (1988) 2.45
Mutational spectrum of chromium(VI) in human cells. Mutat Res (1994) 2.09
Isolation of a human lymphoblastoid line heterozygous at the thymidine kinase locus: possibility for a rapid human cell mutation assay. Biochem Biophys Res Commun (1978) 1.91
Relative sensitivities of forward and reverse mutation assays in Salmonella typhimurium. Proc Natl Acad Sci U S A (1978) 1.74
Deletion mutagenesis during polymerase chain reaction: dependence on DNA polymerase. Gene (1991) 1.71
Optimization of the polymerase chain reaction with regard to fidelity: modified T7, Taq, and vent DNA polymerases. PCR Methods Appl (1991) 1.67
Cell-by-cell scanning of whole mitochondrial genomes in aged human heart reveals a significant fraction of myocytes with clonally expanded deletions. Nucleic Acids Res (1999) 1.64
Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine. J Biol Chem (1986) 1.53
Mitochondrial mutational spectra in human cells and tissues. Proc Natl Acad Sci U S A (1997) 1.45
Mutation assay at the thymidine kinase locus in diploid human lymphoblasts. Mutat Res (1982) 1.44
Quantitative assay for mutation in diploid human lymphoblasts using microtiter plates. Anal Biochem (1981) 1.40
Constant denaturant capillary electrophoresis (CDCE): a high resolution approach to mutational analysis. Nucleic Acids Res (1994) 1.39
Molecular analysis of complex human cell populations: mutational spectra of MNNG and ICR-191. Mutat Res (1990) 1.35
Specificity, efficiency, and fidelity of PCR. PCR Methods Appl (1993) 1.35
Fidelity and mutational spectrum of Pfu DNA polymerase on a human mitochondrial DNA sequence. Genome Res (1997) 1.34
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Mutagenicity of soot and associated polycyclic aromatic hydrocarbons to Salmonella typhimurium. Cancer Res (1979) 1.32
Assay for gene mutation in a human lymphoblast line, AHH-1, competent for xenobiotic metabolism. Mutat Res (1984) 1.28
Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. Mutat Res (2000) 1.26
N-nitroso-N-methylurea-induced rat mammary tumors arise from cells with preexisting oncogenic Hras1 gene mutations. Proc Natl Acad Sci U S A (1994) 1.24
Mutational spectra in human B-cells. Spontaneous, oxygen and hydrogen peroxide-induced mutations at the hprt gene. J Mol Biol (1992) 1.20
Cell density dependence of focus formation in the C3H/10T1/2 transformation assay. Cancer Res (1977) 1.20
Mitochondrial mutagenesis in human cells and tissues. Mutat Res (1999) 1.19
Bacterial and human cell mutagenicity study of some C18H10 cyclopenta-fused polycyclic aromatic hydrocarbons associated with fossil fuels combustion. Environ Health Perspect (1993) 1.18
Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States. Mutat Res (2000) 1.13
Potential use of gradient denaturing gel electrophoresis in obtaining mutational spectra from human cells. Carcinog Compr Surv (1985) 1.13
Chemical and toxicological characterization of residential oil burner emissions: II. Mutagenic, tumorigenic, and potential teratogenic activity. Environ Health Perspect (1987) 1.13
Virus production with a newly developed microcarrier system. Appl Environ Microbiol (1977) 1.12
Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. Mutat Res (1998) 1.08
Pyruvate utilization, phosphocholine and adenosine triphosphate (ATP) are markers of human breast tumor progression: a 31P- and 13C-nuclear magnetic resonance (NMR) spectroscopy study. Cancer Res (1995) 1.07
A statistical model to estimate variance in long term-low dose mutation assays: testing of the model in a human lymphoblastoid mutation assay. Mutat Res (1989) 1.07
Optimization of environment for high density Vero cell culture: effect of dissolved oxygen and nutrient supply on cell growth and changes in metabolites. J Cell Sci (1986) 1.06
Mutational spectrometry: a general approach for hot-spot point mutations in selectable genes. Proc Natl Acad Sci U S A (1992) 1.05
Microsomal activation of fluoranthene to mutagenic metabolites. Toxicol Appl Pharmacol (1986) 1.04
Human cell mutagenicity of polycyclic aromatic hydrocarbon components of diesel emissions. Dev Toxicol Environ Sci (1982) 1.03
Quantitative RT-PCR measurement of cytochromes p450 1A1, 1B1, and 2B7, microsomal epoxide hydrolase, and NADPH oxidoreductase expression in lung cells of smokers and nonsmokers. Am J Respir Cell Mol Biol (1997) 1.03
Enzymatic amplification and characterization of large DNA fragments from genomic DNA. Gene (1988) 1.02
Normal bronchial epithelial cell expression of glutathione transferase P1, glutathione transferase M3, and glutathione peroxidase is low in subjects with bronchogenic carcinoma. Cancer Res (2000) 1.01
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Variance estimation in single-cell mutation assays: comparison to experimental observations in human lymphoblasts at 4 gene loci. Mutat Res (1985) 1.01
Mutation of human lymphoblasts by methylnitrosourea. Chem Biol Interact (1976) 1.00
Mutational spectrometry without phenotypic selection: human mitochondrial DNA. Nucleic Acids Res (1997) 1.00
Evolutionary trail of the mitochondrial genome as based on human 16S rDNA pseudogenes. Gene (1994) 0.99
Phenotypic lag and mutation to 6-thioguanine resistance in diploid human lymphoblasts. Mutat Res (1978) 0.98
Xenobiotic metabolism enzyme gene expression in human bronchial epithelial and alveolar macrophage cells. Am J Respir Cell Mol Biol (1996) 0.98
Mapping large spontaneous deletion endpoints in the human HPRT gene. Mutat Res (1988) 0.97
Mutation of human cells by kerosene soot. J Natl Cancer Inst (1979) 0.97
Combination of competitive quantitative PCR and constant-denaturant capillary electrophoresis for high-resolution detection and enumeration of microbial cells. Appl Environ Microbiol (2001) 0.97
Predominant mutations induced by the Thermococcus litoralis, vent DNA polymerase during DNA amplification in vitro. PCR Methods Appl (1993) 0.95
General approach to the biological analysis of complex mixtures. Environ Health Perspect (1983) 0.95
Morphological transformation of C3H/10T1/2 cells subcultured at low cell densities. Life Sci (1978) 0.94
Measurement of cytochrome P450 2A6 and 2E1 gene expression in primary human bronchial epithelial cells. Carcinogenesis (1998) 0.94
Killing and mutation of human lymphoblast cells by aflatoxin B1: evidence for an inducible repair response. Cancer Res (1987) 0.94
Bell-shaped nuclei dividing by symmetrical and asymmetrical nuclear fission have qualities of stem cells in human colonic embryogenesis and carcinogenesis. Cancer Genet Cytogenet (2006) 0.92
Chemically induced mutations in mitochondrial DNA of human cells: mutational spectrum of N-methyl-N'-nitro-N-nitrosoguanidine. Cancer Res (1998) 0.92
Microcarrier cell culture: new methods for research-scale application. Somatic Cell Genet (1977) 0.91
A sensitive scanning technology for low frequency nuclear point mutations in human genomic DNA. Nucleic Acids Res (2000) 0.91
9-Aminoacridine-A frameshift mutagen for Salmonella typhimurium TA 1537 inactive at the hgprt locus in human lymphoblasts. Mutat Res (1977) 0.90
Human interferon production with diploid fibroblast cells grown on microcarriers. Biotechnol Bioeng (1979) 0.90
Mutational spectrometry: means and ends. Prog Nucleic Acid Res Mol Biol (1994) 0.90
Resolution and conservation of mismatches in DNA end joining. Mutagenesis (1994) 0.88
Analysis of point mutations induced by ultraviolet light in human cells. Mutat Res (1991) 0.87
Concentration-dependent mutation of diploid human lymphoblasts by methylnitronitrosoguanidine: the importance of phenotypic lag. Somatic Cell Genet (1976) 0.87
Use of gradient denaturing gels to determine mutational spectrum in human cells. Basic Life Sci (1986) 0.87
Toxic and mutagenic effects of formaldehyde in Salmonella typhimurium. Mutat Res (1983) 0.86
Mutagenicity of N-nitroso bile acid conjugates in Salmonella typhimurium and diploid human lymphoblasts. Cancer Res (1982) 0.86
Alkyl methane sulfonate mutation of diploid human lymphoblasts and Salmonella typhimurium. Cancer Res (1978) 0.86
Ha-ras-1 oncogene mutations in mammary epithelial cells do not contribute to initiation of spontaneous mammary tumorigenesis in rats. Carcinogenesis (1996) 0.86
Dead cells don't form mutant colonies: a serious source of bias in mutation assays. Environ Mutagen (1985) 0.85
DNA damage produced by ethidium bromide staining and exposure to ultraviolet light. Nucleic Acids Res (1988) 0.85
Binding of cisplatin to specific sequences of human DNA in vitro. Mutat Res (1988) 0.84
Mutation of xeroderma pigmentosum lymphoblasts by far-ultraviolet light. Mutat Res (1984) 0.84
Mutation of human lymphoblasts exposed to low concentrations of chemical mutagens for long periods of time. Mutat Res (1983) 0.84
Studies of mutagenicity and clastogenicity of 5-azacytidine in human lymphoblasts and Salmonella typhimurium. Mutat Res (1986) 0.84
Mutagenicity of hydroxamic acids and the probable involvement of carbamoylation. Cancer Res (1980) 0.84
Growth of mammalian cells at high oxygen concentrations. J Cell Sci (1989) 0.84
Spontaneous and induced chromosomal aberrations and gene mutations in human lymphoblasts: mitomycin C, methylnitrosourea, and ethylnitrosourea. Mutat Res (1986) 0.82
Formaldehyde is mutagenic for cultured human cells. Mutat Res (1983) 0.82
Maintenance of perpetual synchrony in HeLa S3 culture: theoretical and empirical approaches. Methods Cell Biol (1976) 0.82
Comparative mutagenicity of ICR-191 to S. typhimurium and diploid human lymphoblasts. Mutat Res (1977) 0.81
Mutational spectra of a 100-base pair mitochondrial DNA target sequence in bronchial epithelial cells: a comparison of smoking and nonsmoking twins. Cancer Res (1998) 0.81
Multi-copy nuclear pseudogenes of mitochondrial DNA reveal recent acute genetic changes in the human genome. Curr Genet (1995) 0.81
Ultraviolet light-induced mutation of diploid human lymphoblasts. Mutat Res (1983) 0.81
Methylmethacrylate is a mutagen for Salmonella typhimurium. J Bone Joint Surg Am (1979) 0.80
13C- and 31P-NMR studies of human colon cancer in-vitro and in-vivo. Surg Oncol (1993) 0.80
High yields from microcarrier cultures by medium perfusion. J Cell Sci (1983) 0.80
Mutagenicity of mono- and dinitropyrenes in the Salmonella typhimurium TM677 forward mutation assay. Mutat Res (1994) 0.80
Use of wide-bore capillaries in constant denaturant capillary electrophoresis. Electrophoresis (1996) 0.80
A human cell line sensitive to mutation by particle-borne chemicals. Mutat Res (1985) 0.80
Mutational spectra vary with exposure conditions: benzo[a]pyrene in human cells. Mutat Res (1996) 0.80
High density mammalian cell growth in Leibovitz bicarbonate-free medium: effects of fructose and galactose on culture biochemistry. J Cell Sci (1985) 0.79
Applications of constant denaturant capillary electrophoresis/high-fidelity polymerase chain reaction to human genetic analysis. Electrophoresis (1999) 0.79
Parameters affecting cell growth on reduced charge microcarriers. Dev Biol Stand (1979) 0.79
Separation of transforming amino acid-substituting mutations in codons 12, 13 and 61 the N-ras gene by constant denaturant capillary electrophoresis (CDCE). Carcinogenesis (1995) 0.79