Tumor necrosis factor receptor- associated factor 6 (TRAF6) regulation of development, function, and homeostasis of the immune system.

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Published in Immunol Rev on July 01, 2015

Authors

Matthew C Walsh1, JangEun Lee1, Yongwon Choi1

Author Affiliations

1: Institute for Immunology and Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

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CYLD is a deubiquitinating enzyme that negatively regulates NF-kappaB activation by TNFR family members. Nature (2003) 6.00

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The involvement of multiple tumor necrosis factor receptor (TNFR)-associated factors in the signaling mechanisms of receptor activator of NF-kappaB, a member of the TNFR superfamily. J Biol Chem (1998) 1.86

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New insights into ubiquitin E3 ligase mechanism. Nat Struct Mol Biol (2014) 1.82

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miR-146a controls the resolution of T cell responses in mice. J Exp Med (2012) 1.81

The TAK1-TRAF6 signalling pathway. Int J Biochem Cell Biol (2010) 1.79