Differential Activity of Nivolumab, Pembrolizumab and MPDL3280A according to the Tumor Expression of Programmed Death-Ligand-1 (PD-L1): Sensitivity Analysis of Trials in Melanoma, Lung and Genitourinary Cancers.

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Published in PLoS One on June 18, 2015

Authors

Luisa Carbognin1, Sara Pilotto1, Michele Milella2, Vanja Vaccaro2, Matteo Brunelli3, Anna Caliò3, Federica Cuppone4, Isabella Sperduti5, Diana Giannarelli5, Marco Chilosi3, Vincenzo Bronte3, Aldo Scarpa6, Emilio Bria1, Giampaolo Tortora1

Author Affiliations

1: Medical Oncology, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
2: Medical Oncology, Regina Elena National Cancer Institute, Roma, Italy.
3: Department of Pathology and Diagnostic, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy.
4: Agenzia Italiana del Farmaco (AIFA), Roma, Italy.
5: Biostatistics, Regina Elena National Cancer Institute, Roma, Italy.
6: Department of Pathology and Diagnostic, University of Verona, Azienda Ospedaliera Universitaria Integrata, Verona, Italy; ARC-NET Center for Applied Research on Cancer, Verona, Italy.

Associated clinical trials:

CAR-T Cell Immunotherapy for Advanced Lung Cancer | NCT03330834

Pembro + Blina Combination in Pediatric and Young Adult Patients With Relapsed/Refractory Acute Leukemia or Lymphoma | NCT03605589

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