Published in Oncoscience on April 28, 2015
Deciphering intra-tumor heterogeneity of lung adenocarcinoma confirms that dominant, branching, and private gene mutations occur within individual tumor nodules. Virchows Arch (2016) 0.84
Restricting retrotransposons: a review. Mob DNA (2016) 0.79
T cell exhaustion: from pathophysiological basics to tumor immunotherapy. Cell Commun Signal (2017) 0.78
Zinc enhancement of cytidine deaminase activity highlights a potential allosteric role of loop-3 in regulating APOBEC3 enzymes. Sci Rep (2015) 0.78
Structural and functional assessment of APOBEC3G macromolecular complexes. Methods (2016) 0.77
Multi-nucleotide de novo Mutations in Humans. PLoS Genet (2016) 0.76
Cytidine deaminase Apobec3a induction in fallopian epithelium after exposure to follicular fluid. Gynecol Oncol (2017) 0.75
Putative RNA-Directed Adaptive Mutations in Cancer Evolution. Transcription (2016) 0.75
Base changes in tumour DNA have the power to reveal the causes and evolution of cancer. Oncogene (2016) 0.75
AIDing cancer treatment: Reducing AID activity via HSP90 inhibition. Eur J Immunol (2015) 0.75
Activation induced deaminase mutational signature overlaps with CpG methylation sites in follicular lymphoma and other cancers. Sci Rep (2016) 0.75
Progressive APOBEC3B mRNA expression in distant breast cancer metastases. PLoS One (2017) 0.75
A Novel Regulator of Activation-Induced Cytidine Deaminase/APOBECs in Immunity and Cancer: Schrödinger's CATalytic Pocket. Front Immunol (2017) 0.75
Higher Expression of Activation-induced Cytidine Deaminase Is Significantly Associated with Merkel Cell Polyomavirus-negative Merkel Cell Carcinomas. Yonago Acta Med (2017) 0.75
Instability and decay of the primary structure of DNA. Nature (1993) 25.58
Signatures of mutational processes in human cancer. Nature (2013) 21.63
Isolation of a human gene that inhibits HIV-1 infection and is suppressed by the viral Vif protein. Nature (2002) 21.53
Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme. Cell (2000) 20.83
Mutational processes molding the genomes of 21 breast cancers. Cell (2012) 11.22
Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2). Cell (2000) 9.99
Genome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency. Nature (2010) 8.84
DNA demethylation in zebrafish involves the coupling of a deaminase, a glycosylase, and gadd45. Cell (2008) 8.62
Subclonal phylogenetic structures in cancer revealed by ultra-deep sequencing. Proc Natl Acad Sci U S A (2008) 7.22
AID mutates E. coli suggesting a DNA deamination mechanism for antibody diversification. Nature (2002) 7.12
An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22. Genomics (2002) 7.10
Molecular mechanisms of antibody somatic hypermutation. Annu Rev Biochem (2007) 6.92
Specific expression of activation-induced cytidine deaminase (AID), a novel member of the RNA-editing deaminase family in germinal center B cells. J Biol Chem (1999) 6.67
Immunoglobulin isotype switching is inhibited and somatic hypermutation perturbed in UNG-deficient mice. Curr Biol (2002) 6.55
Cytidine deamination of retroviral DNA by diverse APOBEC proteins. Curr Biol (2004) 6.51
Reprogramming towards pluripotency requires AID-dependent DNA demethylation. Nature (2010) 6.20
A second human antiretroviral factor, APOBEC3F, is suppressed by the HIV-1 and HIV-2 Vif proteins. EMBO J (2004) 5.67
Spatial and temporal diversity in genomic instability processes defines lung cancer evolution. Science (2014) 5.63
Human APOBEC3F is another host factor that blocks human immunodeficiency virus type 1 replication. J Virol (2004) 5.35
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
Transcription-targeted DNA deamination by the AID antibody diversification enzyme. Nature (2003) 5.20
APOBEC3B is an enzymatic source of mutation in breast cancer. Nature (2013) 5.18
RNA editing enzyme APOBEC1 and some of its homologs can act as DNA mutators. Mol Cell (2002) 5.14
Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet (2004) 5.04
Retroviral restriction by APOBEC proteins. Nat Rev Immunol (2004) 5.00
APOBEC3F properties and hypermutation preferences indicate activity against HIV-1 in vivo. Curr Biol (2004) 4.89
Activation-induced cytidine deaminase deaminates deoxycytidine on single-stranded DNA but requires the action of RNase. Proc Natl Acad Sci U S A (2003) 4.89
Processive AID-catalysed cytosine deamination on single-stranded DNA simulates somatic hypermutation. Nature (2003) 4.84
An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers. Nat Genet (2013) 4.69
Mechanisms of B-cell lymphoma pathogenesis. Nat Rev Cancer (2005) 4.66
Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions. Mol Cell (2012) 4.52
The APOBEC3 cytidine deaminases: an innate defensive network opposing exogenous retroviruses and endogenous retroelements. Annu Rev Immunol (2008) 4.27
Class-switch recombination: interplay of transcription, DNA deamination and DNA repair. Nat Rev Immunol (2004) 4.04
Replication protein A interacts with AID to promote deamination of somatic hypermutation targets. Nature (2004) 3.94
AID is required for c-myc/IgH chromosome translocations in vivo. Cell (2004) 3.89
Somatic hypermutagenesis in immunoglobulin genes. II. Influence of neighbouring base sequences on mutagenesis. Biochim Biophys Acta (1992) 3.75
Helicobacter pylori infection triggers aberrant expression of activation-induced cytidine deaminase in gastric epithelium. Nat Med (2007) 3.70
Translocation-capture sequencing reveals the extent and nature of chromosomal rearrangements in B lymphocytes. Cell (2011) 3.65
APOBEC3 proteins mediate the clearance of foreign DNA from human cells. Nat Struct Mol Biol (2010) 3.61
Comparison of the differential context-dependence of DNA deamination by APOBEC enzymes: correlation with mutation spectra in vivo. J Mol Biol (2004) 3.59
Evolution of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases. Mol Biol Evol (2004) 3.57
Molecular cloning of an apolipoprotein B messenger RNA editing protein. Science (1993) 3.52
Cellular myc oncogene is altered by chromosome translocation to an immunoglobulin locus in murine plasmacytomas and is rearranged similarly in human Burkitt lymphomas. Proc Natl Acad Sci U S A (1983) 3.40
The AID/APOBEC family of nucleic acid mutators. Genome Biol (2008) 3.25
Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes. Science (1998) 3.22
Constitutive expression of AID leads to tumorigenesis. J Exp Med (2003) 3.16
E-proteins directly regulate expression of activation-induced deaminase in mature B cells. Nat Immunol (2003) 3.03
Quantitative profiling of the full APOBEC3 mRNA repertoire in lymphocytes and tissues: implications for HIV-1 restriction. Nucleic Acids Res (2010) 2.96
Activation-induced cytidine deaminase targets DNA at sites of RNA polymerase II stalling by interaction with Spt5. Cell (2010) 2.92
AID is required for germinal center-derived lymphomagenesis. Nat Genet (2007) 2.79
BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci. Proc Natl Acad Sci U S A (1998) 2.76
Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1. Proc Natl Acad Sci U S A (2004) 2.69
DNA deaminases induce break-associated mutation showers with implication of APOBEC3B and 3A in breast cancer kataegis. Elife (2013) 2.67
The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature (2005) 2.63
Immunity through DNA deamination. Trends Biochem Sci (2003) 2.39
Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1. Mol Cell (2008) 2.39
Estrogen directly activates AID transcription and function. J Exp Med (2009) 2.37
Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots. Proc Natl Acad Sci U S A (1993) 2.30
Transcriptome-wide sequencing reveals numerous APOBEC1 mRNA-editing targets in transcript 3' UTRs. Nat Struct Mol Biol (2011) 2.04
Evidence for mutation showers. Proc Natl Acad Sci U S A (2007) 2.00
Hypermutability of damaged single-strand DNA formed at double-strand breaks and uncapped telomeres in yeast Saccharomyces cerevisiae. PLoS Genet (2008) 2.00
AID is essential for immunoglobulin V gene conversion in a cultured B cell line. Curr Biol (2002) 1.98
The balance between Pax5 and Id2 activities is the key to AID gene expression. J Exp Med (2003) 1.96
Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A (2006) 1.95
The p27 catalytic subunit of the apolipoprotein B mRNA editing enzyme is a cytidine deaminase. J Biol Chem (1993) 1.93
The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals. BMC Mol Biol (2008) 1.85
Proteasomal degradation restricts the nuclear lifespan of AID. J Exp Med (2008) 1.80
Immunoglobulin class-switch DNA recombination: induction, targeting and beyond. Nat Rev Immunol (2012) 1.80
Induction of activation-induced cytidine deaminase gene expression by IL-4 and CD40 ligation is dependent on STAT6 and NFkappaB. Int Immunol (2004) 1.79
All APOBEC3 family proteins differentially inhibit LINE-1 retrotransposition. Nucleic Acids Res (2007) 1.79
Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78
RNA editing: cytidine to uridine conversion in apolipoprotein B mRNA. Biochim Biophys Acta (2000) 1.77
Association of a germline copy number polymorphism of APOBEC3A and APOBEC3B with burden of putative APOBEC-dependent mutations in breast cancer. Nat Genet (2014) 1.68
Migrating bubble during break-induced replication drives conservative DNA synthesis. Nature (2013) 1.66
B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell (2014) 1.58
Mice deficient in APOBEC2 and APOBEC3. Mol Cell Biol (2005) 1.55
Somatic hypermutation of the B cell receptor genes B29 (Igbeta, CD79b) and mb1 (Igalpha, CD79a). Proc Natl Acad Sci U S A (2003) 1.55
Accumulation of somatic mutations in TP53 in gastric epithelium with Helicobacter pylori infection. Gastroenterology (2014) 1.52
APOBEC-mediated cytosine deamination links PIK3CA helical domain mutations to human papillomavirus-driven tumor development. Cell Rep (2014) 1.50
APOBEC4, a new member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases predicted by computational analysis. Cell Cycle (2005) 1.49
The APOBEC3 family of retroelement restriction factors. Curr Top Microbiol Immunol (2013) 1.46
Expression of activation-induced cytidine deaminase in human hepatocytes via NF-kappaB signaling. Oncogene (2007) 1.43
Convergent transcription at intragenic super-enhancers targets AID-initiated genomic instability. Cell (2014) 1.43
De novo protein synthesis is required for the activation-induced cytidine deaminase function in class-switch recombination. Proc Natl Acad Sci U S A (2003) 1.43
APOBEC3B upregulation and genomic mutation patterns in serous ovarian carcinoma. Cancer Res (2013) 1.43
14-3-3 adaptor proteins recruit AID to 5'-AGCT-3'-rich switch regions for class switch recombination. Nat Struct Mol Biol (2010) 1.41
APOBEC3B can impair genomic stability by inducing base substitutions in genomic DNA in human cells. Sci Rep (2012) 1.40
Somatic mutation of the CD95 gene in human B cells as a side-effect of the germinal center reaction. J Exp Med (2000) 1.40
Functions and regulation of the APOBEC family of proteins. Semin Cell Dev Biol (2011) 1.38
A common deletion in the APOBEC3 genes and breast cancer risk. J Natl Cancer Inst (2013) 1.36
AID/APOBEC cytosine deaminase induces genome-wide kataegis. Biol Direct (2012) 1.36
The stability of AID and its function in class-switching are critically sensitive to the identity of its nuclear-export sequence. Proc Natl Acad Sci U S A (2009) 1.34
Regulation of activation-induced deaminase stability and antibody gene diversification by Hsp90. J Exp Med (2010) 1.33
APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest (2011) 1.23
APOBEC-2, a cardiac- and skeletal muscle-specific member of the cytidine deaminase supergene family. Biochem Biophys Res Commun (1999) 1.23
APOBEC3B and AID have similar nuclear import mechanisms. J Mol Biol (2012) 1.22
The splicing regulator PTBP2 interacts with the cytidine deaminase AID and promotes binding of AID to switch-region DNA. Nat Immunol (2010) 1.20
Deficiency in APOBEC2 leads to a shift in muscle fiber type, diminished body mass, and myopathy. J Biol Chem (2009) 1.19