Therapeutic efficacy of combined BRAF and MEK inhibition in metastatic melanoma: a comprehensive network meta-analysis of randomized controlled trials.

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🔗 View Article (PMID 26143635)

Published in Oncotarget on September 29, 2015

Authors

Ruiqin Mai1, Songxia Zhou2, Weixiang Zhong3, Siming Rong2, Zhichao Cong2, Yunxian Li2, Qizhi Xie2, Huanming Chen2, Xiaoyun Li2, Shuhui Liu2, Yabin Cheng4, Yuanshen Huang4, Youwen Zhou4, Guohong Zhang2,4

Author Affiliations

1: Department of Laboratory Medicine, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong, China.
2: Department of Pathology, Shantou University Medical College, Shantou, Guangdong, China.
3: Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
4: Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.

Associated clinical trials:

A Study of Vemurafenib (RO5185426) in Comparison With Dacarbazine in Previously Untreated Patients With Metastatic Melanoma (BRIM 3) | NCT01006980

Investigate Safety, Pharmacokinetics and Pharmacodynamics of GSK2118436 & GSK1120212 | NCT01072175

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma | NCT01584648

Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma (COMBI-v) | NCT01597908

A Study Comparing GSK2118436 to Dacarbazine (DTIC) in Previously Untreated Subjects With BRAF Mutation Positive Advanced (Stage III) or Metastatic (Stage IV) Melanoma | NCT01227889

GSK1120212 vs Chemotherapy in Advanced or Metastatic BRAF V600E/K Mutation-positive Melanoma | NCT01245062

A Phase III Study Comparing Vemurafenib vs Vemurafenib Plus Cobimetinib (GDC-0973) in Patients With Metastatic Melanoma (coBRIM) | NCT01689519

Temozolomide or Selumetinib in Treating Patients With Metastatic Melanoma of the Eye | NCT01143402

CP-675,206 Versus Either Dacarbazine Or Temozolomide In Patients Without Prior Therapy | NCT00257205

Comparison of AZD6244 in Combination With Dacarbazine Versus (vs) Dacarbazine Alone in BRAF Mutation Positive Melanoma Patients | NCT00936221

Carboplatin and Paclitaxel With or Without Sorafenib Tosylate in Treating Patients With Stage III or Stage IV Melanoma That Cannot Be Removed by Surgery | NCT00110019

Randomised Study to Compare the Efficacy of AZD6244 vs TMZ | NCT00338130

Docetaxel With or Without AZD6244 in Melanoma (DOC-MEK) | NCT01256359

A Treatment Combination for Patients With Unresectable Stage III or Stage IV Melanoma | NCT00111007

Treatment for Subjects With Unresectable Stage III or Stage IV Melanoma | NCT00110994

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