Published in Nat Commun on July 17, 2015
Effects of FTY720 on Heart and Lung Functions in Healthy Volunteers | NCT00416845
Glucocorticoid receptors: finding the middle ground. J Clin Invest (2017) 0.79
Respiratory Mucosal Proteome Quantification in Human Influenza Infections. PLoS One (2016) 0.79
Immune regulation by glucocorticoids. Nat Rev Immunol (2017) 0.79
Glucocorticoid-independent modulation of GR activity: Implications for immunotherapy. Pharmacol Ther (2016) 0.78
Cistrome-based Cooperation between Airway Epithelial Glucocorticoid Receptor and NF-κB Orchestrates Anti-inflammatory Effects. J Biol Chem (2016) 0.77
Glucocorticoid and TNF signaling converge at A20 (TNFAIP3) to repress airway smooth muscle cytokine expression. Am J Physiol Lung Cell Mol Physiol (2016) 0.76
Endothelial Response to Glucocorticoids in Inflammatory Diseases. Front Immunol (2016) 0.75
Copper Deficiency in the Lungs of TNF-α Transgenic Mice. Front Physiol (2016) 0.75
GR-independent down-modulation on GM-CSF bone marrow-derived dendritic cells by the selective glucocorticoid receptor modulator Compound A. Sci Rep (2016) 0.75
Sphingosine 1-Phosphate: A Novel Target for Lung Disorders. Front Immunol (2017) 0.75
Dicer ablation in osteoblasts by Runx2 driven cre-loxP recombination affects bone integrity, but not glucocorticoid-induced suppression of bone formation. Sci Rep (2016) 0.75
The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling. FASEB J (2017) 0.75
Plasmodium berghei NK65 in Combination with IFN-γ Induces Endothelial Glucocorticoid Resistance via Sustained Activation of p38 and JNK. Front Immunol (2017) 0.75
The acute respiratory distress syndrome. N Engl J Med (2000) 25.38
One-year outcomes in survivors of the acute respiratory distress syndrome. N Engl J Med (2003) 11.77
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev (2004) 9.54
Efficacy and safety of corticosteroids for persistent acute respiratory distress syndrome. N Engl J Med (2006) 9.52
Signaling mechanisms regulating endothelial permeability. Physiol Rev (2006) 7.63
Methylprednisolone infusion in early severe ARDS: results of a randomized controlled trial. Chest (2007) 7.49
DNA binding of the glucocorticoid receptor is not essential for survival. Cell (1998) 6.40
Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol (2008) 6.10
Notch-RBP-J signaling controls the homeostasis of CD8- dendritic cells in the spleen. J Exp Med (2007) 5.09
Sphingosine 1-phosphate promotes endothelial cell barrier integrity by Edg-dependent cytoskeletal rearrangement. J Clin Invest (2001) 5.05
Use of corticosteroids in acute lung injury and acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care Med (2009) 4.90
An official American Thoracic Society workshop report: features and measurements of experimental acute lung injury in animals. Am J Respir Cell Mol Biol (2011) 4.65
p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev (2005) 3.88
Sphingosine-1-phosphate is a missing cofactor for the E3 ubiquitin ligase TRAF2. Nature (2010) 3.59
Protective effects of sphingosine 1-phosphate in murine endotoxin-induced inflammatory lung injury. Am J Respir Crit Care Med (2004) 3.59
Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clin Neuropharmacol (2010) 3.26
Mice deficient in sphingosine kinase 1 are rendered lymphopenic by FTY720. J Biol Chem (2004) 3.22
Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem (1998) 2.92
Safety and efficacy of fingolimod in patients with relapsing-remitting multiple sclerosis (FREEDOMS II): a double-blind, randomised, placebo-controlled, phase 3 trial. Lancet Neurol (2014) 2.80
Sphingosine 1-phosphate reduces vascular leak in murine and canine models of acute lung injury. Am J Respir Crit Care Med (2004) 2.73
Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. J Clin Invest (2009) 2.41
Fas (CD95) induces alveolar epithelial cell apoptosis in vivo: implications for acute pulmonary inflammation. Am J Pathol (2001) 2.18
Report of the American-European Consensus conference on acute respiratory distress syndrome: definitions, mechanisms, relevant outcomes, and clinical trial coordination. Consensus Committee. J Crit Care (1994) 2.07
In vitro and in vivo modulation of vascular barrier integrity by sphingosine 1-phosphate: mechanistic insights. Cell Signal (2005) 2.01
Activation of sphingosine kinase-1 reverses the increase in lung vascular permeability through sphingosine-1-phosphate receptor signaling in endothelial cells. Circ Res (2008) 1.85
Macrophages and neutrophils are the targets for immune suppression by glucocorticoids in contact allergy. J Clin Invest (2007) 1.51
Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes. Mol Cell (2012) 1.51
Macrophage glucocorticoid receptors regulate Toll-like receptor 4-mediated inflammatory responses by selective inhibition of p38 MAP kinase. Blood (2007) 1.48
The role of the glucocorticoid receptor in inflammation and immunity. J Steroid Biochem Mol Biol (2010) 1.42
Differential effects of sphingosine 1-phosphate receptors on airway and vascular barrier function in the murine lung. Am J Respir Cell Mol Biol (2009) 1.36
ARDS: clinical lessons from the oleic acid model of acute lung injury. Am J Respir Crit Care Med (1994) 1.35
The versatile role of MSKs in transcriptional regulation. Trends Biochem Sci (2009) 1.33
Glucocorticoid-induced granulocytosis: contribution of marrow release and demargination of intravascular granulocytes. Circulation (1998) 1.31
Erythrocytes serve as a reservoir for cellular and extracellular sphingosine 1-phosphate. J Cell Biochem (2010) 1.24
Physiologic, biochemical, and imaging characterization of acute lung injury in mice. Am J Respir Crit Care Med (2005) 1.23
Sphingosine kinase 1 regulates the expression of proinflammatory cytokines and nitric oxide in activated microglia. Neuroscience (2009) 1.18
Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression. Am J Respir Cell Mol Biol (2010) 1.13
Sphingosine kinase protects lipopolysaccharide-activated macrophages from apoptosis. Mol Cell Biol (2004) 1.12
Differential regulation of sphingosine kinases 1 and 2 in lung injury. Am J Physiol Lung Cell Mol Physiol (2009) 1.11
Glucocorticoid receptor dimerization is required for survival in septic shock via suppression of interleukin-1 in macrophages. FASEB J (2011) 1.10
A critical role for sphingosine kinase in anaphylatoxin-induced neutropenia, peritonitis, and cytokine production in vivo. J Immunol (2005) 1.10
Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome. Crit Care Med (1996) 1.07
Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cytoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med (Berl) (2009) 1.06
The alpha-isoform of p38 MAPK specifically regulates arthritic bone loss. J Immunol (2009) 1.06
Targeting inflammation using selective glucocorticoid receptor modulators. Curr Opin Pharmacol (2010) 1.05
Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages. Prostaglandins Other Lipid Mediat (2007) 1.05
Antiinflammatory functions of p38 in mouse models of rheumatoid arthritis: advantages of targeting upstream kinases MKK-3 or MKK-6. Arthritis Rheum (2012) 1.05
Prednisolone-induced differential gene expression in mouse liver carrying wild type or a dimerization-defective glucocorticoid receptor. BMC Genomics (2010) 1.05
Corticosteroids for severe sepsis: an evidence-based guide for physicians. Ann Intensive Care (2011) 1.04
Glucocorticoid receptor dimerization induces MKP1 to protect against TNF-induced inflammation. J Clin Invest (2012) 1.03
Glucocorticoid treatment in acute lung injury and acute respiratory distress syndrome. Crit Care Clin (2011) 1.01
Genomic redistribution of GR monomers and dimers mediates transcriptional response to exogenous glucocorticoid in vivo. Genome Res (2015) 0.99
Pharmacological treatments in ARDS; a state-of-the-art update. BMC Med (2013) 0.99
The impact of endogenous annexin A1 on glucocorticoid control of inflammatory arthritis. Ann Rheum Dis (2012) 0.96
Roles for the mitogen-activated protein kinase (MAPK) phosphatase, DUSP1, in feedback control of inflammatory gene expression and repression by dexamethasone. J Biol Chem (2014) 0.96
Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol (2008) 0.95
Glucocorticoid therapy of antigen-induced arthritis depends on the dimerized glucocorticoid receptor in T cells. Proc Natl Acad Sci U S A (2011) 0.95
An increase in serum C18 unsaturated free fatty acids as a predictor of the development of acute respiratory distress syndrome. Crit Care Med (1996) 0.93
Sphingosine kinases are not required for inflammatory responses in macrophages. J Biol Chem (2013) 0.93
Glucocorticoids protect renal mesangial cells from apoptosis by increasing cellular sphingosine-1-phosphate. Kidney Int (2010) 0.89
Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry. Methods Mol Biol (2012) 0.85
Functional promoter variants in sphingosine 1-phosphate receptor 3 associate with susceptibility to sepsis-associated acute respiratory distress syndrome. Am J Physiol Lung Cell Mol Physiol (2013) 0.84
Glucocorticoids and mitogen- and stress-activated protein kinase 1 inhibitors: possible partners in the combat against inflammation. Biochem Pharmacol (2008) 0.83
Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J Dermatol Sci (2013) 0.83
Role of p38 MAP kinase in the development of acute lung injury. Clin Immunol (2001) 0.81
Activation of the lung S1P(1) receptor reduces allergen-induced plasma leakage in mice. Br J Pharmacol (2009) 0.81
Mitogen- and stress-activated protein kinase 1 MSK1 regulates glucocorticoid response element promoter activity in a glucocorticoid concentration-dependent manner. Eur J Pharmacol (2013) 0.80
Focusing on the flood: targeting functional polymorphisms in ALI permeability pathways. Am J Respir Crit Care Med (2011) 0.79
Corticosteroids and ARDS: A review of treatment and prevention evidence. Lung India (2011) 0.77
Molecular mechanisms of the glucocorticoid receptor in steroid therapy - lessons from transgenic mice. Biomol Concepts (2012) 0.76