Anticancer Cytokines: Biology and Clinical Effects of Interferon-α2, Interleukin (IL)-2, IL-15, IL-21, and IL-12.

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Published in Semin Oncol on June 03, 2015


Theofanis Floros1, Ahmad A Tarhini2

Author Affiliations

1: University of Pittsburgh Cancer Institute, Pittsburgh, PA; Athens Naval and Veterans Hospital, Pittsburgh, PA.
2: University of Pittsburgh Cancer Institute, Pittsburgh, PA; University of Pittsburgh School of Medicine, Pittsburgh, PA. Electronic address:

Associated clinical trials:

Safety Study of IL-21/Anti-PD-1 Combination in the Treatment of Solid Tumors | NCT01629758

Haploidentical Donor Natural Killer Cell Infusion With IL-15 in Acute Myelogenous Leukemia (AML) | NCT01385423

Recombinant Interleukin-15 in Treating Patients With Advanced Melanoma, Kidney Cancer, Non-small Cell Lung Cancer, or Squamous Cell Head and Neck Cancer | NCT01727076

Continuous Infusion of rhIL-15 for Adults With Advanced Cancer | NCT01572493

NK White Blood Cells and Interleukin in Children and Young Adults With Advanced Solid Tumors | NCT01875601

Safety Study of IL-21/Ipilimumab Combination in the Treatment of Melanoma | NCT01489059

IL-15 Super Agonist ALT-803 to Treat Relapse Of Hematologic Malignancy After Allogeneic SCT | NCT01885897

IL15 Dendritic Cell Vaccine for Patients With Resected Stage III (A, B or C) or Stage IV Melanoma | NCT01189383

IL-21-Expanded NK Cells for Induction of Acute Myeloid Leukemia (AML) | NCT01787474

A Phase 1 Study of the Clinical and Immunologic Effects of ALT-803 in Patients With Advanced Solid Tumors | NCT01946789

NCT 02138734

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