Intranodal vaccination with mRNA-optimized dendritic cells in metastatic melanoma patients.

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Published in Oncoimmunology on April 01, 2015

Authors

Kalijn F Bol1, Carl G Figdor2, Erik Hjg Aarntzen3, Marieke Eb Welzen4, Michelle M van Rossum5, Willeke Am Blokx6, Mandy Wmm van de Rakt2, Nicole M Scharenborg2, Annemiek J de Boer2, Jeanette M Pots2, Michel Am Olde Nordkamp2, Tom Gm van Oorschot2, Roel Dm Mus7, Sandra Aj Croockewit8, Joannes Fm Jacobs9, Gerold Schuler10, Bart Neyns11, Jonathan M Austyn12, Cornelis Ja Punt13, Gerty Schreibelt2, I Jolanda M de Vries1

Author Affiliations

1: Department of Tumor Immunology (Radboud Institute for Molecular Life Sciences); Radboud university medical centre ; Nijmegen, The Netherlands ; Medical Oncology; Radboud university medical centre ; Nijmegen, The Netherlands.
2: Department of Tumor Immunology (Radboud Institute for Molecular Life Sciences); Radboud university medical centre ; Nijmegen, The Netherlands.
3: Department of Tumor Immunology (Radboud Institute for Molecular Life Sciences); Radboud university medical centre ; Nijmegen, The Netherlands ; Radiology and Nuclear Medicine; Radboud university medical centre ; Nijmegen, The Netherlands.
4: Pharmacy; Radboud university medical centre ; Nijmegen, The Netherlands.
5: Dermatology; Radboud university medical centre ; Nijmegen, The Netherlands.
6: Pathology; Radboud university medical centre ; Nijmegen, The Netherlands.
7: Radiology and Nuclear Medicine; Radboud university medical centre ; Nijmegen, The Netherlands.
8: Hematology; Radboud university medical centre ; Nijmegen, The Netherlands.
9: Laboratory Medicine; Radboud university medical centre ; Nijmegen, The Netherlands.
10: Department of Dermatology; University Hospital Erlangen ; Erlangen, Germany.
11: Department of Medical Oncology; Vrije Universiteit Brussel ; Brussels, Belgium.
12: Nuffield Department of Surgical Sciences; John Radcliffe Hospital; University of Oxford ; Oxford, UK.
13: Department of Medical Oncology; Academic Medical Center ; Amsterdam, The Netherlands.

Associated clinical trials:

Single-step Antigen Loading and TLR Activation of Dendritic Cells in Melanoma Patients | NCT01530698

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