Mitochondrial Dysfunction Due to Lack of Manganese Superoxide Dismutase Promotes Hepatocarcinogenesis.

European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS). Redox Biol (2017) 0.77

Metabolic zonation of the liver: The oxygen gradient revisited. Redox Biol (2017) 0.75

Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods (1983) 114.35

Wnt signaling and cancer. Genes Dev (2000) 18.53

XTcf-3 transcription factor mediates beta-catenin-induced axis formation in Xenopus embryos. Cell (1996) 11.70

Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology (1982) 11.24

Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev (1999) 6.38

A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal Biochem (1976) 5.38

Role of superoxide dismutase in cancer: a review. Cancer Res (1979) 3.34

CuZnSOD deficiency leads to persistent and widespread oxidative damage and hepatocarcinogenesis later in life. Oncogene (2005) 3.17

Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol (2007) 3.11

Hypoxia-inducible factor 1alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol (2003) 3.10

The Ala16Val genetic dimorphism modulates the import of human manganese superoxide dismutase into rat liver mitochondria. Pharmacogenetics (2003) 2.87

Superoxide dismutases in the lung and human lung diseases. Am J Respir Crit Care Med (2003) 2.49

O2 regulates stem cells through Wnt/β-catenin signalling. Nat Cell Biol (2010) 2.45

Purification, induction, and distribution of placental glutathione transferase: a new marker enzyme for preneoplastic cells in the rat chemical hepatocarcinogenesis. Proc Natl Acad Sci U S A (1985) 2.32

N-nitrosodiethylamine mechanistic data and risk assessment: bioactivation, DNA-adduct formation, mutagenicity, and tumor initiation. Pharmacol Ther (1996) 2.24

NAFLD, NASH and liver cancer. Nat Rev Gastroenterol Hepatol (2013) 2.20

beta-Catenin mutation and overexpression in hepatocellular carcinoma: clinicopathologic and prognostic significance. Cancer (2001) 2.17

Oxygen: modulator of metabolic zonation and disease of the liver. Hepatology (2000) 2.12

Increased manganese superoxide dismutase expression suppresses the malignant phenotype of human melanoma cells. Proc Natl Acad Sci U S A (1993) 2.08

Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr (1996) 2.03

Heterogeneous distribution of glutamine synthetase among rat liver parenchymal cells in situ and in primary culture. EMBO J (1983) 1.84

Mitochondrial manganese-superoxide dismutase expression in ovarian cancer: role in cell proliferation and response to oxidative stress. J Biol Chem (2005) 1.64

Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes. Blood (1999) 1.60

Manganese superoxide dismutase enhances the invasive and migratory activity of tumor cells. Cancer Res (2007) 1.52

Phenotypic changes induced in human breast cancer cells by overexpression of manganese-containing superoxide dismutase. Oncogene (1995) 1.46

Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk. Carcinogenesis (2001) 1.37

Model mice for tissue-specific deletion of the manganese superoxide dismutase (MnSOD) gene. Biochem Biophys Res Commun (2002) 1.27

Manganese superoxide dismutase suppresses hypoxic induction of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Oncogene (2005) 1.26

Manganese superoxide dismutase regulation and cancer. Free Radic Biol Med (2012) 1.26

Liver zonation occurs through a beta-catenin-dependent, c-Myc-independent mechanism. Gastroenterology (2009) 1.25

Suppression of the malignant phenotype of human glioma cells by overexpression of manganese superoxide dismutase. Oncogene (1997) 1.25

Inhibition of cell growth by overexpression of manganese superoxide dismutase (MnSOD) in human pancreatic carcinoma. Free Radic Res (2004) 1.25

SOD2: a new type of tumor-suppressor gene? Int J Cancer (1992) 1.24

Conditional beta-catenin loss in mice promotes chemical hepatocarcinogenesis: role of oxidative stress and platelet-derived growth factor receptor alpha/phosphoinositide 3-kinase signaling. Hepatology (2010) 1.23

Manganese superoxide dismutase alanine-to-valine polymorphism at codon 16 and lung cancer risk. J Natl Cancer Inst (2001) 1.21

Perivenous expression of the mRNA of the three hypoxia-inducible factor alpha-subunits, HIF1alpha, HIF2alpha and HIF3alpha, in rat liver. Biochem J (2001) 1.16

Complementary DNA encoding human colon cancer manganese superoxide dismutase and the expression of its gene in human cells. Cancer Res (1991) 1.14

Reduced expression of E-cadherin/catenin complex in hepatocellular carcinomas. World J Gastroenterol (2008) 1.12

Transcription dynamics in a physiological process: β-catenin signaling directs liver metabolic zonation. Int J Biochem Cell Biol (2009) 1.10

GSK-3β regulates cell growth, migration, and angiogenesis via Fbw7 and USP28-dependent degradation of HIF-1α. Blood (2011) 1.10

Human mitochondrial manganese superoxide dismutase polymorphic variant Ile58Thr reduces activity by destabilizing the tetrameric interface. Biochemistry (1996) 1.05

Tumor hypoxia blocks Wnt processing and secretion through the induction of endoplasmic reticulum stress. Mol Cell Biol (2008) 1.04

Manganese superoxide dismutase is a p53-regulated gene that switches cancers between early and advanced stages. Cancer Res (2011) 1.02

Potential mechanisms for the inhibition of tumor cell growth by manganese superoxide dismutase. Antioxid Redox Signal (2001) 1.01

Hypoxia-inducible factor-1alpha obstructs a Wnt signaling pathway by inhibiting the hARD1-mediated activation of beta-catenin. Cancer Res (2008) 1.01

Isolation and characterization of complementary DNAs encoding human manganese-containing superoxide dismutase. FEBS Lett (1988) 1.01

Oxidative damage to DNA and aging. Exerc Sport Sci Rev (2003) 0.98

Deregulation of manganese superoxide dismutase (SOD2) expression and lymph node metastasis in tongue squamous cell carcinoma. BMC Cancer (2010) 0.98

Heterogeneous distribution of glutamine synthetase during rat liver development. J Histochem Cytochem (1987) 0.98

Antioxidant enzyme levels as a function of growth state in cell culture. Free Radic Biol Med (1995) 0.98

Superoxide dismutase activity in WI-38 cell cultures: effects of age, trypsinization and SV-40 transformation. Physiol Chem Phys (1974) 0.97

Superoxide and derived reactive oxygen species in the regulation of hypoxia-inducible factors. Methods Enzymol (2007) 0.96

Prognostic significance of glutamine synthetase expression in unifocal advanced hepatocellular carcinoma. J Hepatol (2000) 0.94

Identification of cysteine residues involved in disulfide formation in the inactivation of glutathione transferase P-form by hydrogen peroxide. Arch Biochem Biophys (1993) 0.93

Mutations in the SOD2 promoter reveal a molecular basis for an activating protein 2-dependent dysregulation of manganese superoxide dismutase expression in cancer cells. Mol Cancer Res (2008) 0.92

Manganese superoxide dismutase (SOD2/MnSOD)/catalase and SOD2/GPx1 ratios as biomarkers for tumor progression and metastasis in prostate, colon, and lung cancer. Free Radic Biol Med (2015) 0.90

Glutamine synthetase and hepatocarcinogenesis. Carcinogenesis (1995) 0.88

The Wnt/beta-catenin pathway: master regulator of liver zonation? Bioessays (2006) 0.87

β-catenin links von Hippel-Lindau to aurora kinase A and loss of primary cilia in renal cell carcinoma. J Am Soc Nephrol (2014) 0.86

Manganese superoxide dismutase inhibits neointima formation through attenuation of migration and proliferation of vascular smooth muscle cells. Free Radic Biol Med (2011) 0.86

PAI-1 modulates cell migration in a LRP1-dependent manner via β-catenin and ERK1/2. Thromb Haemost (2015) 0.86

Preferential selection of MnSOD transcripts in proliferating normal and cancer cells. Oncogene (2011) 0.86

Deficiency of manganese superoxide dismutase in hepatocytes disrupts zonated gene expression in mouse liver. Arch Biochem Biophys (2007) 0.86

Maintenance of mitochondrial genomic integrity in the absence of manganese superoxide dismutase in mouse liver hepatocytes. Redox Biol (2013) 0.86

Hydrogen peroxide contributes to the manganese superoxide dismutase promotion of migration and invasion in glioma cells. Free Radic Res (2011) 0.85

Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species. J Biol Chem (1989) 0.83

Hypoxia-induced β-catenin downregulation involves p53-dependent activation of Siah-1. Cancer Sci (2011) 0.81

Manganese superoxide dismutase is reduced in the liver of male but not female humans and rodents with non-alcoholic fatty liver disease. Exp Mol Pathol (2013) 0.80

Decreased activity of liver glutathione peroxidase in human hepatocellular carcinoma. Eur J Cancer Clin Oncol (1985) 0.78