Targeting of HPV-16+ Epithelial Cancer Cells by TCR Gene Engineered T Cells Directed against E6.

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🔗 View Article (PMID 26429982)

Published in Clin Cancer Res on October 01, 2015

Authors

Lindsey M Draper1, Mei Li M Kwong1, Alena Gros1, Sanja Stevanović1, Eric Tran1, Sid Kerkar2, Mark Raffeld2, Steven A Rosenberg1, Christian S Hinrichs3

Author Affiliations

1: Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
2: Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland.
3: Surgery Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland. Hinrichs@nih.gov.

Associated clinical trials:

T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers | NCT02280811

E7 TCR T Cells With or Without PD-1 Blockade for Human Papillomavirus-Associated Cancers | NCT02858310

Phase I Trial of LMP2 Antigen-specific TCR T-cell Therapy for Recurrent and Metastatic NPC Patients | NCT03925896

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