Multiple Pathways Control the Reactivation of Telomerase in HTLV-I-Associated Leukemia.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26430700)

Published in Int J Cancer Oncol on June 02, 2015

Authors

Marcia Bellon1, Christophe Nicot1

Author Affiliations

1: Department of Pathology and Laboratory Medicine, Center for Viral Oncology, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.

Articles citing this

Telomerase Activation in Hematological Malignancies. Genes (Basel) (2016) 0.75

Human T-cell lymphotropic virus type 1 and its oncogenesis. Acta Pharmacol Sin (2017) 0.75

Articles cited by this

(truncated to the top 100)

Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma. Proc Natl Acad Sci U S A (1980) 30.08

Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev (2005) 15.19

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell (1997) 13.34

A DNA damage checkpoint response in telomere-initiated senescence. Nature (2003) 12.55

The somatic genomic landscape of glioblastoma. Cell (2013) 11.73

How shelterin protects mammalian telomeres. Annu Rev Genet (2008) 11.20

Adult T-cell leukemia: clinical and hematologic features of 16 cases. Blood (1977) 10.69

DNA damage-induced phosphorylation of p53 alleviates inhibition by MDM2. Cell (1997) 10.52

hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell (1997) 8.74

Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature (2000) 7.28

Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature (2007) 6.82

Chk2/hCds1 functions as a DNA damage checkpoint in G(1) by stabilizing p53. Genes Dev (2000) 5.90

Monoclonal integration of human T-cell leukemia provirus in all primary tumors of adult T-cell leukemia suggests causative role of human T-cell leukemia virus in the disease. Proc Natl Acad Sci U S A (1984) 4.97

Telomeres: protecting chromosomes against genome instability. Nat Rev Mol Cell Biol (2010) 4.23

Senescence induced by altered telomere state, not telomere loss. Science (2002) 4.17

Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell (2006) 4.13

Cellular transcription factors and regulation of IL-2 receptor gene expression by HTLV-I tax gene product. Science (1988) 4.01

Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I. Science (1995) 3.43

Human telomerase and its regulation. Microbiol Mol Biol Rev (2002) 3.11

HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci U S A (2006) 3.11

Thymus-derived leukemia-lymphoma in mice transgenic for the Tax gene of human T-lymphotropic virus type I. Nat Med (2006) 2.81

Definition, prognostic factors, treatment, and response criteria of adult T-cell leukemia-lymphoma: a proposal from an international consensus meeting. J Clin Oncol (2008) 2.67

Dysfunctional telomeres activate an ATM-ATR-dependent DNA damage response to suppress tumorigenesis. EMBO J (2007) 2.61

Telomerase activity is restored in human cells by ectopic expression of hTERT (hEST2), the catalytic subunit of telomerase. Oncogene (1998) 2.56

Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer (2008) 2.54

Multiple viral strategies of HTLV-1 for dysregulation of cell growth control. Annu Rev Immunol (2001) 2.54

Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). Nucleic Acids Res (2000) 2.54

Methylation of the TERT promoter and risk stratification of childhood brain tumours: an integrative genomic and molecular study. Lancet Oncol (2013) 2.34

Akt protein kinase enhances human telomerase activity through phosphorylation of telomerase reverse transcriptase subunit. J Biol Chem (1999) 2.34

Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene. Cancer Res (1999) 2.32

The telomeric protein TRF2 binds the ATM kinase and can inhibit the ATM-dependent DNA damage response. PLoS Biol (2004) 2.23

Multiple roles for MRE11 at uncapped telomeres. Nature (2009) 2.18

Telomerase activity in human cancer. Curr Opin Oncol (1996) 2.13

Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci (2008) 2.13

Telomeres, telomerase, and immortality. J Natl Cancer Inst (1995) 2.12

Activation of NF-kappaB by HTLV-I and implications for cell transformation. Oncogene (2005) 2.10

Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J (2000) 2.05

Exocrinopathy resembling Sjögren's syndrome in HTLV-1 tax transgenic mice. Nature (1989) 1.98

Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep (2007) 1.96

The nature of telomere fusion and a definition of the critical telomere length in human cells. Genes Dev (2007) 1.88

Regulation of the human catalytic subunit of telomerase (hTERT). Gene (2012) 1.81

Cutting edge: telomerase activation in human T lymphocytes does not require increase in telomerase reverse transcriptase (hTERT) protein but is associated with hTERT phosphorylation and nuclear translocation. J Immunol (2001) 1.77

Impact of HTLV-I Tax on cell cycle progression and the cellular DNA damage repair response. Oncogene (2005) 1.74

Telomere-related genome instability in cancer. Cold Spring Harb Symp Quant Biol (2005) 1.69

POT1b protects telomeres from end-to-end chromosomal fusions and aberrant homologous recombination. EMBO J (2006) 1.66

Central role of PI3K in transcriptional activation of hTERT in HTLV-I-infected cells. Blood (2008) 1.61

Interleukin-2 receptor (Tac antigen) expressed on adult T cell leukemia cells. J Clin Invest (1985) 1.58

Human T-cell leukemia virus type I (HTLV-1) proviral load and disease progression in asymptomatic HTLV-1 carriers: a nationwide prospective study in Japan. Blood (2010) 1.57

Persistent clonal proliferation of human T-lymphotropic virus type I-infected cells in vivo. Cancer Res (1997) 1.56

Telomere dysfunction and chromosome instability. Mutat Res (2011) 1.51

Constitutive and regulated expression of telomerase reverse transcriptase (hTERT) in human lymphocytes. Proc Natl Acad Sci U S A (1999) 1.42

Telomerase is controlled by protein kinase Calpha in human breast cancer cells. J Biol Chem (1998) 1.38

Persistent inhibition of telomerase reprograms adult T-cell leukemia to p53-dependent senescence. Blood (2006) 1.33

Transcriptional activation of hTERT through the NF-kappaB pathway in HTLV-I-transformed cells. Blood (2004) 1.32

Recruitment of SH2-containing protein tyrosine phosphatase SHP-1 to the interleukin 2 receptor; loss of SHP-1 expression in human T-lymphotropic virus type I-transformed T cells. Proc Natl Acad Sci U S A (1998) 1.30

HTLV-1 HBZ cooperates with JunD to enhance transcription of the human telomerase reverse transcriptase gene (hTERT). Retrovirology (2007) 1.29

Nuclear factor-kappaB p65 mediates tumor necrosis factor alpha-induced nuclear translocation of telomerase reverse transcriptase protein. Cancer Res (2003) 1.28

Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. J Biol Chem (1997) 1.28

HBZ, a new important player in the mystery of adult T-cell leukemia. Blood (2006) 1.27

Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity. Biochimie (2007) 1.26

Human T-lymphotropic virus type I tax activates I-kappa B kinase by inhibiting I-kappa B kinase-associated serine/threonine protein phosphatase 2A. J Biol Chem (2002) 1.25

Abnormal centrosome amplification in cells through the targeting of Ran-binding protein-1 by the human T cell leukemia virus type-1 Tax oncoprotein. Proc Natl Acad Sci U S A (2005) 1.24

Regulation of telomerase and telomeres: human tumor viruses take control. J Natl Cancer Inst (2008) 1.24

Human T cell lymphotropic virus type I Tax activates IL-15R alpha gene expression through an NF-kappa B site. J Immunol (2001) 1.21

Cellular transformation by the HTLV-I Tax protein, a jack-of-all-trades. Oncogene (2003) 1.19

Clonal expansion of infected cells: a way of life for HTLV-I. J Acquir Immune Defic Syndr Hum Retrovirol (1996) 1.18

Phosphoinositide-3 kinase-PKB/Akt pathway activation is involved in fibroblast Rat-1 transformation by human T-cell leukemia virus type I tax. Oncogene (2001) 1.17

HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways. Front Microbiol (2012) 1.16

Regulation of the hTERT telomerase catalytic subunit by the c-Abl tyrosine kinase. Curr Biol (2000) 1.14

Telomere repeat binding factors: keeping the ends in check. Cancer Lett (2003) 1.13

HTLV-I Tax-dependent and -independent events associated with immortalization of human primary T lymphocytes. Blood (2010) 1.13

The role of double-strand break repair pathways at functional and dysfunctional telomeres. Cold Spring Harb Perspect Biol (2014) 1.12

Treatment of adult T-cell leukaemia/lymphoma: current strategy and future perspectives. Virus Res (2001) 1.11

Cytogenetic and immunophenotypic analysis of cell lines established from patients with T cell leukemia/lymphoma. Blood (1986) 1.11

Preferential selection of human T-cell leukemia virus type 1 provirus lacking the 5' long terminal repeat during oncogenesis. J Virol (2007) 1.10

Chromatin and epigenetic regulation of the telomerase reverse transcriptase gene. Protein Cell (2010) 1.07

Telomeres. Curr Opin Cell Biol (1991) 1.07

Activation of the IL-2 gene promoter by HTLV-I tax involves induction of NF-AT complexes bound to the CD28-responsive element. EMBO J (1996) 1.04

Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. Proc Natl Acad Sci U S A (2013) 1.03

hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells. Br J Cancer (2006) 1.03

Inactivation of hTERT transcription by Tax. Oncogene (2003) 1.01

The roles of telomeres and telomerase in cell life span. Mutat Res (1996) 1.01

POT1 association with TRF2 regulates telomere length. Mol Cell Biol (2009) 1.01

Mechanisms of persistent NF-kappaB activation by HTLV-I tax. IUBMB Life (2005) 1.01

Nuclear protein tyrosine phosphatase Shp-2 is one important negative regulator of nuclear export of telomerase reverse transcriptase. J Biol Chem (2008) 1.00

Cytogenetic analysis and clinical significance in adult T-cell leukemia/lymphoma: a study of 50 cases from the human T-cell leukemia virus type-1 endemic area, Nagasaki. Blood (2001) 0.97

Increased expression of telomere length regulating factors TRF1, TRF2 and TIN2 in patients with adult T-cell leukemia. Int J Cancer (2006) 0.97

Evidence against a direct cytotoxic effect of alpha interferon and zidovudine in HTLV-I associated adult T cell leukemia/lymphoma. Leukemia (2000) 0.96

Interaction of human T-cell lymphotropic virus type I Tax, Ets1, and Sp1 in transactivation of the PTHrP P2 promoter. J Biol Chem (1997) 0.96

The HTLV-I Tax oncoprotein: hyper-tasking at the molecular level. Front Biosci (2005) 0.95

The tax protein of human T-cell leukemia virus type 1 mediates the transactivation of the c-sis/platelet-derived growth factor-B promoter through interactions with the zinc finger transcription factors Sp1 and NGFI-A/Egr-1. J Biol Chem (1997) 0.95

Significance of HTLV-1 proviral load quantification by real-time PCR as a surrogate marker for HTLV-1-infected cell count. Clin Lab Haematol (2003) 0.94

Significance of soluble interleukin-2 receptor levels for evaluation of the progression of adult T-cell leukemia. Cancer (1994) 0.92

Telomerase recruitment to telomeres. Cytogenet Genome Res (2009) 0.92

Insights into the molecular mechanism of p53 inhibition by HTLV type 1 Tax. AIDS Res Hum Retroviruses (2000) 0.92

Human T-cell lymphotropic virus type 1 Tax1 activation of NF-kappa B: involvement of the protein kinase C pathway. J Virol (1996) 0.92

Cytokine expression and tumorigenicity of large granular lymphocytic leukemia cells from mice transgenic for the tax gene of human T-cell leukemia virus type I. Blood (1997) 0.91

Human T cell leukemia virus type 1: the role of Tax in leukemogenesis. Arch Immunol Ther Exp (Warsz) (2005) 0.91

Setting the stage for transformation: HTLV-1 Tax inhibition of p53 function. Front Biosci (2005) 0.89

Dual roles of telomere dysfunction in initiation and suppression of tumorigenesis. Exp Cell Res (2008) 0.89

Articles by these authors

Tumor Suppressor Inactivation in the Pathogenesis of Adult T-Cell Leukemia. J Oncol (2015) 0.84