Published in Antimicrob Agents Chemother on October 05, 2015
Role for the plasmodium falciparum digestive vacuole in chloroquine resistance. Biochem Pharmacol (1998) 1.65
PfCRT and its role in antimalarial drug resistance. Trends Parasitol (2012) 1.63
Structure-function relationships in aminoquinolines: effect of amino and chloro groups on quinoline-hematin complex formation, inhibition of beta-hematin formation, and antiplasmodial activity. J Med Chem (2000) 1.52
Primaquine: the risks and the benefits. Malar J (2014) 1.51
Primaquine synergises the activity of chloroquine against chloroquine-resistant P. falciparum. Biochem Pharmacol (2005) 1.31
In vitro and in vivo reversal of chloroquine resistance in Plasmodium falciparum with promethazine. Am J Trop Med Hyg (1998) 1.21
Structure-activity relationships in 4-aminoquinoline antiplasmodials. The role of the group at the 7-position. J Med Chem (2002) 1.20
Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolines. J Med Chem (2008) 1.09
Synthesis and antimalarial activity of new 4-amino-7-chloroquinolyl amides, sulfonamides, ureas and thioureas. Bioorg Med Chem (2008) 1.00
Reversal agent and linker variants of reversed chloroquines: activities against Plasmodium falciparum. J Med Chem (2010) 0.90
Synthesis and antimalarial evaluation of new N1-(7-chloro-4-quinolyl)-1,4-bis(3-aminopropyl)piperazine derivatives. Bioorg Med Chem Lett (2005) 0.86
Quinine dimers are potent inhibitors of the Plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum. ACS Chem Biol (2014) 0.86
To kill or not to kill, that is the question: cytocidal antimalarial drug resistance. Trends Parasitol (2014) 0.85
Novel 4-aminoquinoline analogs highly active against the blood and sexual stages of Plasmodium in vivo and in vitro. Antimicrob Agents Chemother (2012) 0.82
Characterization of native PfABCG protein in Plasmodium falciparum. Biochem Pharmacol (2015) 0.75