Cognitive and behavior deficits in sickle cell mice are associated with profound neuropathologic changes in hippocampus and cerebellum.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26462816)

Published in Neurobiol Dis on October 14, 2015

Authors

Li Wang1, Luis E F Almeida1, Celia M de Souza Batista2, Alfia Khaibullina1, Nuo Xu1, Sarah Albani1, Kira A Guth1, Ji Sung Seo1, Martha Quezado3, Zenaide M N Quezado4

Author Affiliations

1: The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, United States.
2: Department of Nutritional Sciences, Howard University, Washington DC 20059, United States.
3: Laboratory of Pathology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, United States.
4: The Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's Research Institute, United States; Divisions of Anesthesiology and Pain Medicine, Children's National Health System, United States; Center for Neuroscience Research, Children's Research Institute, Children's National Health System, School of Medicine and Health Sciences, George Washington University, Washington, DC 20010, United States. Electronic address: zquezado@childrensnational.org.

Articles cited by this

Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Science (2007) 12.41

Cerebrovascular accidents in sickle cell disease: rates and risk factors. Blood (1998) 6.72

The human hippocampus and spatial and episodic memory. Neuron (2002) 6.09

The use of a plus-maze to measure anxiety in the mouse. Psychopharmacology (Berl) (1987) 5.35

Transgenic knockout mice with exclusively human sickle hemoglobin and sickle cell disease. Science (1997) 4.25

Assessing substrates underlying the behavioral effects of antidepressants using the modified rat forced swimming test. Neurosci Biobehav Rev (2005) 3.32

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice. Mol Psychiatry (2004) 2.55

Pain-related behaviors and neurochemical alterations in mice expressing sickle hemoglobin: modulation by cannabinoids. Blood (2010) 2.45

Sensitivity to the effects of pharmacologically selective antidepressants in different strains of mice. Psychopharmacology (Berl) (2001) 2.44

Pathology of Berkeley sickle cell mice: similarities and differences with human sickle cell disease. Blood (2005) 2.37

Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adults with sickle cell anemia. JAMA (2010) 2.25

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy. Neurobiol Dis (2008) 2.20

Correction of sickle cell disease by homologous recombination in embryonic stem cells. Blood (2006) 1.92

Lesions of the medial striatum in monkeys produce perseverative impairments during reversal learning similar to those produced by lesions of the orbitofrontal cortex. J Neurosci (2008) 1.88

"Behavioural despair" in rats and mice: strain differences and the effects of imipramine. Eur J Pharmacol (1978) 1.61

Brain neuroplastic changes accompany anxiety and memory deficits in a model of complex regional pain syndrome. Anesthesiology (2014) 1.56

Neuropsychologic performance in school-aged children with sickle cell disease: a report from the Cooperative Study of Sickle Cell Disease. J Pediatr (2001) 1.46

The use of a running wheel to measure activity in rodents: relationship to energy balance, general activity, and reward. Neurosci Biobehav Rev (2012) 1.45

Inflammation-induced decrease in voluntary wheel running in mice: a nonreflexive test for evaluating inflammatory pain and analgesia. Pain (2012) 1.42

Functional coding variation in recombinant inbred mouse lines reveals multiple serotonin transporter-associated phenotypes. Proc Natl Acad Sci U S A (2009) 1.38

Depression and anxiety in adults with sickle cell disease: the PiSCES project. Psychosom Med (2007) 1.29

Gestational and neonatal iron deficiency alters apical dendrite structure of CA1 pyramidal neurons in adult rat hippocampus. Dev Neurosci (2010) 1.18

Physiological correlates of intellectual function in children with sickle cell disease: hypoxaemia, hyperaemia and brain infarction. Dev Sci (2006) 1.17

Cognitive impairment in children with hemoglobin SS sickle cell disease: relationship to MR imaging findings and hematocrit. AJNR Am J Neuroradiol (2003) 1.15

A new animal model for assessing mechanisms and management of muscle hyperalgesia. Pain (2000) 1.14

Cognitive screening examinations for silent cerebral infarcts in sickle cell disease. Neurology (1998) 1.11

Mouse models for studying pain in sickle disease: effects of strain, age, and acuteness. Br J Haematol (2011) 1.09

Wheel running in the wild. Proc Biol Sci (2014) 1.08

Sickle cell disease as a neurodevelopmental disorder. Ment Retard Dev Disabil Res Rev (2006) 1.05

Factors influencing behavior in the forced swim test. Physiol Behav (2013) 1.04

Neurocognitive development of young children with sickle cell disease through three years of age. J Pediatr Psychol (2002) 1.02

Somatic symptom burden in adults with sickle cell disease predicts pain, depression, anxiety, health care utilization, and quality of life: the PiSCES project. Psychosomatics (2011) 1.01

Procedural learning and cognitive flexibility in a mouse model of restricted, repetitive behaviour. Behav Brain Res (2008) 1.00

Sensitization of nociceptive spinal neurons contributes to pain in a transgenic model of sickle cell disease. Pain (2015) 0.98

Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice. Nutr Neurosci (2003) 0.97

Magnetic resonance imaging/angiography and transcranial Doppler velocities in sickle cell anemia: results from the SWiTCH trial. Blood (2014) 0.96

Sickle cell mice exhibit mechanical allodynia and enhanced responsiveness in light touch cutaneous mechanoreceptors. Mol Pain (2012) 0.94

Sleep disturbance, depression and pain in adults with sickle cell disease. BMC Psychiatry (2014) 0.94

Cardiopulmonary responses to exercise in women with sickle cell anemia. Am J Respir Crit Care Med (2002) 0.94

Impaired acquisition of a Morris water maze task following selective destruction of cerebellar purkinje cells with OX7-saporin. Behav Brain Res (2000) 0.93

Infant maternal separation impairs adult cognitive performance in BALB/cJ mice. Psychopharmacology (Berl) (2011) 0.89

Developmental function in toddlers with sickle cell anemia. Pediatrics (2013) 0.88

Respiratory muscle force and lung volume changes in a population of children with sickle cell disease. Br J Haematol (2013) 0.88

Neurobehavioral impact of sickle cell disease in early childhood. J Int Neuropsychol Soc (2007) 0.87

Attenuated maximal muscle strength and peak power in children with sickle cell disease. J Pediatr Hematol Oncol (2011) 0.87

Developmental screening in young children with sickle cell disease. Results of a cooperative study. Am J Pediatr Hematol Oncol (1993) 0.87

Suppression of voluntary wheel running in rats is dependent on the site of inflammation: evidence for voluntary running as a measure of hind paw-evoked pain. J Pain (2013) 0.87

Neuroimaging abnormalities in adults with sickle cell anemia: associations with cognition. Neurology (2014) 0.86

Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems. J Neurodev Disord (2010) 0.86

Rodent models of depression: forced swim and tail suspension behavioral despair tests in rats and mice. Curr Protoc Pharmacol (2010) 0.85

Exercise tolerance, lung function abnormalities, anemia, and cardiothoracic ratio in sickle cell patients. Am J Hematol (2014) 0.84

Mental health disorders influence admission rates for pain in children with sickle cell disease. Pediatr Blood Cancer (2012) 0.83

Sickle cell disease in mice is associated with sensitization of sensory nerve fibers. Exp Biol Med (Maywood) (2014) 0.82

Iron, inflammation, and early death in adults with sickle cell disease. Circ Res (2014) 0.82

The impact of sickle cell disease on exercise capacity in children. Chest (2013) 0.82

Psychiatric diagnosis in adolescents with sickle cell disease: a preliminary report. Curr Psychiatry Rep (2011) 0.81

Persistent nociception induces anxiety-like behavior in rodents: role of endogenous neuropeptide S. Pain (2014) 0.81

The Association of Cytokine Levels With Cognitive Function in Children With Sickle Cell Disease and Normal MRI Studies of the Brain. J Child Neurol (2014) 0.80

Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia. Br J Haematol (2013) 0.80

Dexmedetomidine ameliorates nocifensive behavior in humanized sickle cell mice. Eur J Pharmacol (2015) 0.79

Synapses, circuits, and the ontogeny of learning. Dev Psychobiol (2007) 0.79

Depression in children suffering from sickle cell anemia. J Pediatr Hematol Oncol (2015) 0.78

Neurodevelopmental deficits among infants and toddlers with sickle cell disease. J Dev Behav Pediatr (2013) 0.78

Behavior in the elevated plus maze is differentially affected by testing conditions in rats under and over three weeks of age. Front Behav Neurosci (2015) 0.78

Hypoxia and inflammation in children with sickle cell disease: implications for hippocampal functioning and episodic memory. Neuropsychol Rev (2014) 0.77

Genetic mouse models of depression. Curr Top Behav Neurosci (2013) 0.77

Rapamycin increases fetal hemoglobin and ameliorates the nociception phenotype in sickle cell mice. Blood Cells Mol Dis (2015) 0.76