Progress with Plasmodium falciparum sporozoite (PfSPZ)-based malaria vaccines.

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Published in Vaccine on November 27, 2015

Authors

Thomas L Richie1, Peter F Billingsley2, B Kim Lee Sim2, Eric R James2, Sumana Chakravarty2, Judith E Epstein3, Kirsten E Lyke4, Benjamin Mordmüller5, Pedro Alonso6, Patrick E Duffy7, Ogobara K Doumbo8, Robert W Sauerwein9, Marcel Tanner10, Salim Abdulla11, Peter G Kremsner5, Robert A Seder12, Stephen L Hoffman2

Author Affiliations

1: Sanaria Inc., Rockville, MD, United States. Electronic address: trichie@sanaria.com.
2: Sanaria Inc., Rockville, MD, United States.
3: Naval Medical Research Center, Silver Spring, MD, United States.
4: Center for Malaria Research, Institute for Global Health, University of Maryland School of Medicine, Baltimore, MD, United States.
5: Institute of Tropical Medicine, University of Tübingen, Tübingen, Germany.
6: Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
7: Laboratory of Malaria Immunology and Vaccinology, National Institute of Allergy and Infectious Diseases, NIH, Rockville, MD, United States.
8: Malaria Research and Training Center, University of Bamako, Bamako, Mali.
9: Radboud University Medical Center, Nijmegen, The Netherlands.
10: Swiss Tropical and Public Health Institute, Basel, Switzerland.
11: Ifakara Health Institute, Bagamoyo, United Republic of Tanzania.
12: Vaccine Research Center, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD, United States.

Associated clinical trials:

A Clinical Trial of the PfSPZ Vaccine Administered by Direct Venous Inoculation in Healthy Malaria-Naïve Adults: Heterologous vs. Homologous Controlled Human Malaria Infection and Reduction in Number of Doses | NCT02215707

Study of Controlled Human Malaria Infections to Evaluate Protection After Intravenous or Intramuscular Administration of PfSPZ Vaccine in Malaria-Naive Adults | NCT02015091

Safety and Protective Efficacy of Intravenous Immunization With Cryopreserved Plasmodium Falciparum Sporozoites Under Chemoprophylaxis | NCT02115516

Study of Safety and Effectiveness of Intravenous Immunization With PfSPZ Vaccine in Healthy African Adults | NCT01988636

Dose Escalation, Randomized Controlled Trial to Evaluate the Safety, Immunogenicity and Efficacy of Intravenously Administered Attenuated Plasmodium Falciparum Sporozoite Vaccine (PfSPZ Vaccine) in Tanzanian Adults | NCT02132299

Safety and Immunogenicity of Direct Venous Inoculation of a Radiation-attenuated PfSPZ Vaccine in Equatoguinean Adults | NCT02418962

Sanaria PfSPZ Challenge With Pyrimethamine Chemoprophylaxis (PfSPZ-CVac Approach): Phase 1 Trial to Determine Safety and Protective Efficacy of Sanaria PfSPZ Challenge With Concurrent Pyrimethamine Treatment That Inhibits Development of Asexual B... | NCT02511054

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