Published in Nucleic Acids Res on October 30, 2015
Systematic Prioritization of Druggable Mutations in ∼5000 Genomes Across 16 Cancer Types Using a Structural Genomics-based Approach. Mol Cell Proteomics (2015) 0.82
Investigating cellular network heterogeneity and modularity in cancer: a network entropy and unbalanced motif approach. BMC Syst Biol (2016) 0.76
Multi-omic measurement of mutually exclusive loss-of-function enriches for candidate synthetic lethal gene pairs. BMC Genomics (2016) 0.75
mutLBSgeneDB: mutated ligand binding site gene DataBase. Nucleic Acids Res (2016) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res (2008) 54.83
Integrated genomic analyses of ovarian carcinoma. Nature (2011) 47.72
Comprehensive molecular portraits of human breast tumours. Nature (2012) 47.39
A census of human cancer genes. Nat Rev Cancer (2004) 36.20
Comprehensive molecular characterization of human colon and rectal cancer. Nature (2012) 34.13
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature (2012) 31.78
The Unified Medical Language System (UMLS): integrating biomedical terminology. Nucleic Acids Res (2004) 25.99
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
International network of cancer genome projects. Nature (2010) 20.35
Genomic and epigenomic landscapes of adult de novo acute myeloid leukemia. N Engl J Med (2013) 19.87
Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature (2009) 19.65
Comprehensive genomic characterization of squamous cell lung cancers. Nature (2012) 18.90
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
The mutational landscape of head and neck squamous cell carcinoma. Science (2011) 16.88
UniProt: a hub for protein information. Nucleic Acids Res (2014) 16.72
Data, information, knowledge and principle: back to metabolism in KEGG. Nucleic Acids Res (2013) 15.13
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
DrugBank 3.0: a comprehensive resource for 'omics' research on drugs. Nucleic Acids Res (2010) 13.68
Comprehensive molecular characterization of clear cell renal cell carcinoma. Nature (2013) 13.60
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Discovery and saturation analysis of cancer genes across 21 tumour types. Nature (2014) 11.68
Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell (2008) 11.18
Open Babel: An open chemical toolbox. J Cheminform (2011) 11.12
Integrative analysis of 111 reference human epigenomes. Nature (2015) 10.32
Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer (2011) 9.68
The Reactome pathway knowledgebase. Nucleic Acids Res (2013) 8.56
Comprehensive molecular characterization of urothelial bladder carcinoma. Nature (2014) 8.48
Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science (2012) 6.79
DrugBank 4.0: shedding new light on drug metabolism. Nucleic Acids Res (2013) 6.73
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013. Nucleic Acids Res (2013) 6.17
Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell (2012) 6.09
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
Comprehensive genomic characterization of head and neck squamous cell carcinomas. Nature (2015) 5.50
Whole genomes redefine the mutational landscape of pancreatic cancer. Nature (2015) 4.01
Genomic Classification of Cutaneous Melanoma. Cell (2015) 3.91
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2014) 3.55
Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery. Nucleic Acids Res (2011) 3.05
CancerGenes: a gene selection resource for cancer genome projects. Nucleic Acids Res (2006) 3.00
TSGene: a web resource for tumor suppressor genes. Nucleic Acids Res (2012) 2.90
(13)C-based metabolic flux analysis. Nat Protoc (2009) 2.75
PKM2 isoform-specific deletion reveals a differential requirement for pyruvate kinase in tumor cells. Cell (2013) 2.38
Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32
Comprehensive genomic profiles of small cell lung cancer. Nature (2015) 2.20
Heterogeneity of tumor-induced gene expression changes in the human metabolic network. Nat Biotechnol (2013) 1.91
Metabolic genes in cancer: their roles in tumor progression and clinical implications. Biochim Biophys Acta (2010) 1.88
TCGA-assembler: open-source software for retrieving and processing TCGA data. Nat Methods (2014) 1.86
PharmGKB: the Pharmacogenomics Knowledge Base. Methods Mol Biol (2013) 1.81
TCPA: a resource for cancer functional proteomics data. Nat Methods (2013) 1.64
Blood-brain barrier glucose transporter: effects of hypo- and hyperglycemia revisited. J Neurochem (1999) 1.57
Hypoxic regulation of glutamine metabolism through HIF1 and SIAH2 supports lipid synthesis that is necessary for tumor growth. Cell Metab (2014) 1.15
Targeting the hallmarks of cancer: towards a rational approach to next-generation cancer therapy. Curr Opin Oncol (2013) 1.12
NCG 4.0: the network of cancer genes in the era of massive mutational screenings of cancer genomes. Database (Oxford) (2014) 1.10
Patterns and processes of somatic mutations in nine major cancers. BMC Med Genomics (2014) 1.08
Quantitative network mapping of the human kinome interactome reveals new clues for rational kinase inhibitor discovery and individualized cancer therapy. Oncotarget (2014) 1.07
Prediction of individualized therapeutic vulnerabilities in cancer from genomic profiles. Bioinformatics (2014) 0.99
Comparative study of IDH1 mutations in gliomas by immunohistochemistry and DNA sequencing. Neuro Oncol (2013) 0.98
Reproducible combinatorial regulatory networks elucidate novel oncogenic microRNAs in non-small cell lung cancer. RNA (2014) 0.92
Studying tumorigenesis through network evolution and somatic mutational perturbations in the cancer interactome. Mol Biol Evol (2014) 0.92
Global gene expression and functional network analysis of gastric cancer identify extended pathway maps and GPRC5A as a potential biomarker. Cancer Lett (2012) 0.91
ChiTaRS 2.1--an improved database of the chimeric transcripts and RNA-seq data with novel sense-antisense chimeric RNA transcripts. Nucleic Acids Res (2014) 0.91
Ets-1 global gene expression profile reveals associations with metabolism and oxidative stress in ovarian and breast cancers. Cancer Metab (2013) 0.90
Targeting the AKT pathway in glioblastoma. Curr Pharm Des (2011) 0.90
C2 domains as protein-protein interaction modules in the ciliary transition zone. Cell Rep (2014) 0.88
A Gene Gravity Model for the Evolution of Cancer Genomes: A Study of 3,000 Cancer Genomes across 9 Cancer Types. PLoS Comput Biol (2015) 0.84
Preventive effects of bexarotene and budesonide in a genetically engineered mouse model of small cell lung cancer. Cancer Prev Res (Phila) (2009) 0.81
Long-term effects of inhaled budesonide on screening-detected lung nodules. Ann Oncol (2015) 0.81
Cancer metabolism: A waste of insulin interference. Nature (2015) 0.78
Generalized portrait of cancer metabolic pathways inferred from a list of genes overexpressed in cancer. Genet Res Int (2014) 0.76
A network-based drug repositioning infrastructure for precision cancer medicine through targeting significantly mutated genes in the human cancer genomes. J Am Med Inform Assoc (2016) 0.81
Proteome-Scale Investigation of Protein Allosteric Regulation Perturbed by Somatic Mutations in 7,000 Cancer Genomes. Am J Hum Genet (2016) 0.77