Outcomes of unselected patients with metastatic clear-cell renal cell carcinoma treated with first-line pazopanib therapy followed by vascular endothelial growth factor receptor tyrosine kinase inhibitors or mammalian target of rapamycin inhibitors: a single institution experience.

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Published in BJU Int on December 13, 2015

Authors

Marc R Matrana1, Tharakeswara Bathala2, Matthew T Campbell3, Cihan Duran2, Aditya Shetty1,4, Purnima Teegavarapu5, Sarathi Kalra1,6, Lianchun Xiao7, Bradley Atkinson8, Paul Corn3, Eric Jonasch3, Nizar M Tannir3

Author Affiliations

1: Division of Cancer Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
2: Department of Diagnostic Radiology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
3: Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
4: Hematology and Oncology Fellowship, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
5: Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
6: Division of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA.
7: Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
8: Clinical Pharmacy Programs, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Associated clinical trials:

Study of Nivolumab (BMS-936558) vs. Everolimus in Pre-Treated Advanced or Metastatic Clear-cell Renal Cell Carcinoma (CheckMate 025) | NCT01668784

A Study of Cabozantinib (XL184) vs Everolimus in Subjects With Metastatic Renal Cell Carcinoma (METEOR) | NCT01865747

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