Inhibition of the angiopoietin/Tie2 axis induces immunogenic modulation, which sensitizes human tumor cells to immune attack.

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Published in J Immunother Cancer on November 17, 2015

Authors

Italia Grenga1, Anna R Kwilas1, Renee N Donahue1, Benedetto Farsaci1, James W Hodge1

Author Affiliations

1: Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Center Drive, Room 8B13 MSC 1750, Bethesda, MD 20892 USA.

Associated clinical trials:

I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer (I-SPY 2) | NCT01042379

TRINOVA-1: A Study of AMG 386 or Placebo, in Combination With Weekly Paclitaxel Chemotherapy, as Treatment for Ovarian Cancer, Primary Peritoneal Cancer and Fallopian Tube Cancer | NCT01204749

AMG 386 (Trebananib) in Ovarian Cancer (TRINOVA-2) | NCT01281254

TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and Carboplatin to Treat Ovarian Cancer | NCT01493505

AMG 386 and Abiraterone for Advanced Prostate Cancer | NCT01553188

Phase 2 Study of AMG 386 Plus Paclitaxel With or Without Bevacizumab as First Line Therapy in Her2-Negative Breast Cancer Patients | NCT00511459

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