Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation.

GMP Synthase is Required for Virulence Factor Production and Infection by Cryptococcus neoformans. J Biol Chem (2017) 0.75

PHENIX: a comprehensive Python-based system for macromolecular structure solution. Acta Crystallogr D Biol Crystallogr (2010) 108.52

Features and development of Coot. Acta Crystallogr D Biol Crystallogr (2010) 89.46

XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46

Scalable molecular dynamics with NAMD. J Comput Chem (2005) 59.49

Genome sequence of the human malaria parasite Plasmodium falciparum. Nature (2002) 37.89

Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions. Acta Crystallogr D Biol Crystallogr (2004) 31.52

Systematic analysis of domain motions in proteins from conformational change: new results on citrate synthase and T4 lysozyme. Proteins (1998) 5.91

SuperPose: a simple server for sophisticated structural superposition. Nucleic Acids Res (2004) 4.09

New tricks for modelers from the crystallography toolkit: the particle mesh Ewald algorithm and its use in nucleic acid simulations. Structure (1999) 2.92

The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat Struct Biol (1996) 2.11

The mechanism of glutamine-dependent amidotransferases. Cell Mol Life Sci (1998) 1.44

Site-directed mutagenesis using a single mutagenic oligonucleotide and DpnI digestion of template DNA. Anal Biochem (2003) 1.36

Crystal structure of imidazole glycerol phosphate synthase: a tunnel through a (beta/alpha)8 barrel joins two active sites. Structure (2001) 1.32

Enzymes essential for the biosynthesis of nucleic acid guanine; xanthosine 5'-phosphate aminase of Aerobacter aerogenes. J Biol Chem (1957) 1.28

Toward understanding the mechanism of the complex cyclization reaction catalyzed by imidazole glycerolphosphate synthase: crystal structures of a ternary complex and the free enzyme. Biochemistry (2003) 1.20

Purine salvage pathways in the intraerythrocytic malaria parasite Plasmodium falciparum. Eukaryot Cell (2008) 1.13

Mechanism for acivicin inactivation of triad glutamine amidotransferases. Biochemistry (2001) 1.12

Conformational changes in ammonia-channeling glutamine amidotransferases. Curr Opin Struct Biol (2007) 1.11

Crystal structures of CTP synthetase reveal ATP, UTP, and glutamine binding sites. Structure (2004) 1.01

Synchronization of the three reaction centers within carbamoyl phosphate synthetase. Biochemistry (2000) 1.00

Metabolic fate of fumarate, a side product of the purine salvage pathway in the intraerythrocytic stages of Plasmodium falciparum. J Biol Chem (2011) 0.98

Dynamics of glucosamine-6-phosphate synthase catalysis. Arch Biochem Biophys (2010) 0.89

Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetase. Biochem J (2008) 0.87

Replacement by site-directed mutagenesis indicates a role for histidine 170 in the glutamine amide transfer function of anthranilate synthase. J Biol Chem (1985) 0.87

The glutamine hydrolysis function of human GMP synthetase. Identification of an essential active site cysteine. J Biol Chem (1995) 0.86

Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthase. Exp Parasitol (2000) 0.86

Role of the four conserved histidine residues in the amidotransferase domain of carbamoyl phosphate synthetase. Biochemistry (1991) 0.84

Catalysis uncoupling in a glutamine amidotransferase bienzyme by unblocking the glutaminase active site. Chem Biol (2012) 0.84

Crystal structure of the ATPPase subunit and its substrate-dependent association with the GATase subunit: a novel regulatory mechanism for a two-subunit-type GMP synthetase from Pyrococcus horikoshii OT3. J Mol Biol (2009) 0.80

Substrate-induced conformational changes in Plasmodium falciparum guanosine monophosphate synthetase. FEBS J (2011) 0.79

Ammonia channeling in Plasmodium falciparum GMP synthetase: investigation by NMR spectroscopy and biochemical assays. Biochemistry (2011) 0.79

Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain. Arch Biochem Biophys (2011) 0.79

Substrate specificity and oligomerization of human GMP synthetase. J Mol Biol (2013) 0.79

Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase. Arch Biochem Biophys (2014) 0.78

Substrate activation and conformational dynamics of guanosine 5'-monophosphate synthetase. Biochemistry (2013) 0.78

Importance of hydrophobic cavities in allosteric regulation of formylglycinamide synthetase: insight from xenon trapping and statistical coupling analysis. PLoS One (2013) 0.77

Studies on active site mutants of P. falciparum adenylosuccinate synthetase: insights into enzyme catalysis and activation. Biochim Biophys Acta (2010) 0.76

Unexpected functional implication of a stable succinimide in the structural stability of Methanocaldococcus jannaschii glutaminase. Nat Commun (2016) 0.75

Structural basis of homo- and heterotrimerization of collagen I. Nat Commun (2017) 0.75

Effect of introducing a disulphide bond between the A and C domains on the activity and stability of Saccharomycopsis fibuligera R64 α-amylase. J Biotechnol (2014) 0.75

Crystal structure of recombinant tyrosinase-binding protein MtaL at 1.35 Å resolution. Acta Crystallogr F Struct Biol Commun (2016) 0.75