Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging.

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Published in Proc Natl Acad Sci U S A on November 10, 2015

Authors

Roy L Maute1, Sydney R Gordon1, Aaron T Mayer2, Melissa N McCracken1, Arutselvan Natarajan3, Nan Guo Ring1, Richard Kimura3, Jonathan M Tsai1, Aashish Manglik4, Andrew C Kruse5, Sanjiv S Gambhir2, Irving L Weissman6, Aaron M Ring6

Author Affiliations

1: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305; Department of Pathology, Stanford University Medical Center, Stanford, CA 94305;
2: Department of Radiology, Molecular Imaging Program at Stanford (MIPS), James H. Clark Center, Stanford, CA 94305; Department of Bioengineering, Materials Science and Engineering, Stanford University, Stanford, CA 94305;
3: Department of Radiology, Molecular Imaging Program at Stanford (MIPS), James H. Clark Center, Stanford, CA 94305;
4: Department of Molecular and Cellular Physiology, Stanford University Medical Center, Stanford, CA 94305;
5: Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115.
6: Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305; Ludwig Center for Cancer Stem Cell Research and Medicine, Stanford University School of Medicine, Stanford, CA 94305; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA 94305; Department of Pathology, Stanford University Medical Center, Stanford, CA 94305; aaron.ring@yale.edu irv@stanford.edu.

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