Muscle-invasive urothelial bladder cancer: an update on systemic therapy.

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Published in Ther Adv Urol on December 01, 2015

Authors

Hayley Knollman1, J Luke Godwin1, Rishi Jain1, Yu-Ning Wong1, Elizabeth R Plimack1, Daniel M Geynisman2

Author Affiliations

1: Department of Medical Oncology, Fox Chase Cancer Center-Temple University Health System, Philadelphia, PA, USA.
2: Assistant Professor of Medical Oncology, Fox Chase Cancer Center-Temple University Health System, 333 Cottman Avenue, Philadelphia, PA 19111, USA.

Associated clinical trials:

Study of Pembrolizumab (MK-3475) in Participants With Advanced Solid Tumors (MK-3475-012/KEYNOTE-012) | NCT01848834

A Dose Escalation Study in Adult Patients With Advanced Solid Malignancies | NCT01004224

DN24-02 as Adjuvant Therapy in Subjects With High Risk HER2+ Urothelial Carcinoma | NCT01353222

Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer | NCT00942331

A Study of Atezolizumab in Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer [IMvigor210] | NCT02108652

First-Line Gemcitabine, Cisplatin + Ipilimumab for Metastatic Urothelial Carcinoma | NCT01524991

A Study of Atezolizumab Compared With Chemotherapy in Participants With Locally Advanced or Metastatic Urothelial Bladder Cancer [IMvigor211] | NCT02302807

A Study of Pembrolizumab (MK-3475) Versus Paclitaxel, Docetaxel, or Vinflunine for Participants With Advanced Urothelial Cancer (MK-3475-045/KEYNOTE-045) | NCT02256436

A Study to Evaluate the Safety, Pharmacokinetics, and Pharmacodynamics of JNJ-42756493 in Adult Participants With Advanced or Refractory Solid Tumors or Lymphoma | NCT01703481

First-line Everolimus +/- Paclitaxel for Cisplatin-ineligible Patients With Advanced Urothelial Carcinoma | NCT01215136

Cabozantinib for Advanced Urothelial Cancer | NCT01688999

Trial of Gemcitabine, Carboplatin, and Sorafenib in Chemotherapy-naive Patients With Advanced/Metastatic Bladder Carcinoma | NCT00461851

Lapatinib, Cisplatin, Gemcitabine as First-Line Therapy in Treating Patients With Locally Advanced or Metastatic Urothelial Cancer | NCT00623064

Phase I Dose Escalation Pan-FGFR (Fibroblast Growth Factor Receptor) Inhibitor | NCT01976741

A Phase III Study of Atezolizumab Treatment Versus Observation as Adjuvant Therapy in Patients With PD-L1 Positive, High Risk Muscle Invasive Bladder Cancer After Cystectomy [IMvigor010] | NCT02450331

Gemcitabine and Pazopanib in Chemotherapy Naïve Patients With Advanced/Metastatic Urothelial Carcinoma Ineligible for Cisplatin-based Chemotherapy | NCT01622660

Buparlisib in Metastatic Transitional Cell Carcinoma of the Urothelium | NCT01551030

Gemcitabine and Split-Dose Cisplatin Plus Everolimus (RAD001) in Patients With Advanced Solid Tumor Malignancies | NCT01182168

Study of Pembrolizumab (MK-3475) in Participants With Advanced Urothelial Cancer (MK-3475-052/KEYNOTE-52) | NCT02335424

Neoadjuvant Pembrolizumab in Combination With Gemcitabine Therapy in Cis-eligible/Ineligible UC Subjects | NCT02365766

BIBF1120 in Patients With Advanced FGFR3 Mutated,Overexpressed,or Wild Type Urothelial Carcinoma | NCT02278978

Alisertib in Chemotherapy-pretreated Urothelial Cancer | NCT02109328

A Study of Nivolumab in Participants With Metastatic or Unresectable Bladder Cancer | NCT02387996

Sunitinib Malate in Treating Patients With Recurrent Transitional Cell Bladder Cancer | NCT01118351

A Phase 2 Study of B-701 in Treatment of Locally Advanced or Metastatic Urothelial Cell Carcinoma | NCT02401542

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