c-Met as a Target for Personalized Therapy.

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Published in Transl Oncogenomics on November 23, 2015

Authors

Ingrid Garajová1, Elisa Giovannetti2, Guido Biasco3, Godefridus J Peters4

Author Affiliations

1: Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands. ; Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
2: Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands. ; Cancer Pharmacology Lab, AIRC Start-Up Unit, University of Pisa, Pisa, Italy.
3: Department of Experimental, Diagnostic and Speciality Medicine, University of Bologna, Sant'Orsola-Malpighi Hospital, Bologna, Italy.
4: Department of Medical Oncology, VU University Medical Center, Cancer Center Amsterdam, Amsterdam, The Netherlands.

Associated clinical trials:

A Study Of Oral PF-02341066, A C-Met/Hepatocyte Growth Factor Tyrosine Kinase Inhibitor, In Patients With Advanced Cancer (PROFILE 1001) | NCT00585195

Cabozantinib in Patients With RET Fusion-Positive Advanced Non-Small Cell Lung Cancer and Those With Other Genotypes: ROS1 or NTRK Fusions or Increased MET or AXL Activity | NCT01639508

First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition Factor (MET) - Positive Gastric, Lower Esophageal, or Gastroesophageal Junction (GEJ) Adenocarcinoma (RILOMET-1) | NCT01697072

A Safety and Efficacy Study of INC280 and Gefitinib in Patients With EGFR Mutated, c-MET-amplified NSCLC Who Have Progressed After EGFRi Treatment | NCT01610336

CREATE: Cross-tumoral Phase 2 With Crizotinib (CREATE) | NCT01524926

INC280 and Erlotinib Hydrochloride in Treating Patients With Non-small Cell Lung Cancer | NCT01911507

S1300: Pemetrexed Disodium With or Without Crizotinib in Treating Patients With Stage IV Non-Small Cell Lung Cancer That Has Progressed After Crizotinib | NCT02134912

A Study of Onartuzumab in Combination With Erlotinib in Patients With MET-Positive Stage IIIB or IV Non-Small Cell Lung Cancer Carrying an Activating Epidermal Growth Factor Receptor (EGFR) Mutation | NCT01887886

Pazopanib or Pemetrexed and Crizotinib in Advanced Cancer | NCT01548144

Study of Efficacy and Safety of Nivolumab in Combination With EGF816 and of Nivolumab in Combination With INC280 in Patients With Previously Treated Non-small Cell Lung Cancer (EGF816) | NCT02323126

Erlotinib Hydrochloride or Crizotinib and Chemoradiation Therapy in Treating Patients With Stage III Non-small Cell Lung Cancer | NCT01822496

A Trial of Cabozantinib (XL184) and Gemcitabine in Advanced Pancreatic Cancer | NCT01663272

A Phase 1b Study Of Axitinib In Combination With Crizotinib In Patients With Advanced Solid Tumors | NCT01999972

A Phase II Trial to Evaluate the Efficacy of AZD6094 (HMPL-504) in Patients With Papillary Renal Cell Carcinoma (PRCC) | NCT02127710

MSC2156119J With Gefitinib in Subjects With Locally Advanced or Metastatic Non-small Cell Lung Cancer (NSCLC) | NCT01982955

Dasatinib and Crizotinib in Advanced Cancer | NCT01744652

Sorafenib or Crizotinib and Vemurafenib in Advanced Cancer | NCT01531361

A Phase 2 Study of the MET Kinase Inhibitor INC280 in Papillary Renal Cell Cancer | NCT02019693

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