Published in BMC Genet on December 03, 2015
Pathways to precision medicine in smoking cessation treatments. Neurosci Lett (2016) 0.76
An Adaptive Fisher's Combination Method for Joint Analysis of Multiple Phenotypes in Association Studies. Sci Rep (2016) 0.75
PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet (2007) 209.92
An integrated map of genetic variation from 1,092 human genomes. Nature (2012) 59.82
Standardisation of spirometry. Eur Respir J (2005) 48.20
Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med (2007) 47.86
MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet Epidemiol (2010) 26.41
METAL: fast and efficient meta-analysis of genomewide association scans. Bioinformatics (2010) 21.21
Genome-wide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet (2008) 16.17
A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature (2008) 16.10
Fast and accurate genotype imputation in genome-wide association studies through pre-phasing. Nat Genet (2012) 11.29
Genetic epidemiology of COPD (COPDGene) study design. COPD (2010) 7.67
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet (2009) 6.93
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet (2009) 4.56
Evaluation of COPD Longitudinally to Identify Predictive Surrogate End-points (ECLIPSE). Eur Respir J (2008) 4.53
Genome-wide association study identifies five loci associated with lung function. Nat Genet (2009) 4.10
A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet (2009) 3.78
The CHRNA5-A3 region on chromosome 15q24-25.1 is a risk factor both for nicotine dependence and for lung cancer. J Natl Cancer Inst (2008) 3.67
Variants in FAM13A are associated with chronic obstructive pulmonary disease. Nat Genet (2010) 3.44
Deaths: preliminary data for 2008. Natl Vital Stat Rep (2010) 3.12
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function. Nat Genet (2011) 3.03
Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis. Lancet Respir Med (2014) 2.28
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
A quantitative-trait analysis of human plasma-dopamine beta-hydroxylase activity: evidence for a major functional polymorphism at the DBH locus. Am J Hum Genet (2001) 1.80
Genome-wide study of percent emphysema on computed tomography in the general population. The Multi-Ethnic Study of Atherosclerosis Lung/SNP Health Association Resource Study. Am J Respir Crit Care Med (2014) 1.80
Integration of genomic and genetic approaches implicates IREB2 as a COPD susceptibility gene. Am J Hum Genet (2009) 1.52
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction. Am J Respir Crit Care Med (2012) 1.49
RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway. J Cell Sci (2003) 1.47
Retracted Association of CYP2A6*4 with susceptibility of lung cancer: a meta-analysis. PLoS One (2013) 1.45
Identification of a chronic obstructive pulmonary disease genetic determinant that regulates HHIP. Hum Mol Genet (2011) 1.42
The 15q24/25 susceptibility variant for lung cancer and chronic obstructive pulmonary disease is associated with emphysema. Am J Respir Crit Care Med (2009) 1.36
A novel binding protein composed of homophilic tetramer exhibits unique properties for the small GTPase Rab5. J Biol Chem (2001) 1.21
A genome-wide scan of pulmonary function measures in the National Heart, Lung, and Blood Institute Family Heart Study. Am J Respir Crit Care Med (2003) 1.19
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
The association of genome-wide significant spirometric loci with chronic obstructive pulmonary disease susceptibility. Am J Respir Cell Mol Biol (2011) 1.17
Hedgehog-interacting protein is a COPD susceptibility gene: the Rotterdam Study. Eur Respir J (2009) 1.16
Lung function and airway diseases. Nat Genet (2010) 1.15
Chromosome 4q31 locus in COPD is also associated with lung cancer. Eur Respir J (2010) 1.14
CHRNA3/5, IREB2, and ADCY2 are associated with severe chronic obstructive pulmonary disease in Poland. Am J Respir Cell Mol Biol (2012) 1.13
Strong association between two polymorphisms on 15q25.1 and lung cancer risk: a meta-analysis. PLoS One (2012) 1.07
FAM13A locus in COPD is independently associated with lung cancer - evidence of a molecular genetic link between COPD and lung cancer. Appl Clin Genet (2010) 0.97
Opportunities and challenges in the genetics of COPD 2010: an International COPD Genetics Conference report. COPD (2011) 0.93
Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility. Hum Genet (2013) 0.92
Genetics of COPD and emphysema. Chest (2009) 0.92
Chromosome 15q24-25.1 variants, diet, and lung cancer susceptibility in cigarette smokers. Cancer Causes Control (2011) 0.89
Nicotinic acetylcholine receptor variants associated with susceptibility to chronic obstructive pulmonary disease: a meta-analysis. Respir Res (2011) 0.86
An alternative hypothesis testing strategy for secondary phenotype data in case-control genetic association studies. Front Genet (2014) 0.86
Genetic variants associated with lung function: the long life family study. Respir Res (2014) 0.77
Changes in forced expiratory volume in 1 second over time in COPD. N Engl J Med (2011) 5.69
Pulmonary arterial enlargement and acute exacerbations of COPD. N Engl J Med (2012) 5.54
Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med (2011) 4.75
Chronic obstructive pulmonary disease exacerbations in the COPDGene study: associated radiologic phenotypes. Radiology (2011) 3.30
Comparison of spirometric thresholds in diagnosing smoking-related airflow obstruction. Thorax (2013) 2.88
The clinical features of the overlap between COPD and asthma. Respir Res (2011) 2.29
Relationship between quantitative CT metrics and health status and BODE in chronic obstructive pulmonary disease. Thorax (2012) 2.15
The chronic bronchitic phenotype of COPD: an analysis of the COPDGene Study. Chest (2011) 2.14
Early-onset chronic obstructive pulmonary disease is associated with female sex, maternal factors, and African American race in the COPDGene Study. Am J Respir Crit Care Med (2011) 2.06
Inflammatory biomarkers improve clinical prediction of mortality in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2012) 1.99
A genome-wide association study of COPD identifies a susceptibility locus on chromosome 19q13. Hum Mol Genet (2011) 1.98
Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med (2012) 1.80
Clinical and radiographic predictors of GOLD-unclassified smokers in the COPDGene study. Am J Respir Crit Care Med (2011) 1.76
Characteristics, stability and outcomes of the 2011 GOLD COPD groups in the ECLIPSE cohort. Eur Respir J (2013) 1.66
Racial differences in quality of life in patients with COPD. Chest (2011) 1.64
Association Between Interstitial Lung Abnormalities and All-Cause Mortality. JAMA (2016) 1.61
Genome-wide association identifies regulatory Loci associated with distinct local histogram emphysema patterns. Am J Respir Crit Care Med (2014) 1.57
Reduced Bone Density and Vertebral Fractures in Smokers. Men and COPD Patients at Increased Risk. Ann Am Thorac Soc (2015) 1.54
β-Blockers are associated with a reduction in COPD exacerbations. Thorax (2015) 1.48
Radiological correlates and clinical implications of the paradoxical lung function response to β₂ agonists: an observational study. Lancet Respir Med (2014) 1.41
Quantitative computed tomography of the lungs and airways in healthy nonsmoking adults. Invest Radiol (2012) 1.41
Statins and pulmonary fibrosis: the potential role of NLRP3 inflammasome activation. Am J Respir Crit Care Med (2012) 1.27
Hospitalized exacerbations of COPD: risk factors and outcomes in the ECLIPSE cohort. Chest (2015) 1.25
The clinical impact of non-obstructive chronic bronchitis in current and former smokers. Respir Med (2013) 1.23
Serum PARC/CCL-18 concentrations and health outcomes in chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2011) 1.23
Genome-wide association study of smoking behaviours in patients with COPD. Thorax (2011) 1.18
Genetics of sputum gene expression in chronic obstructive pulmonary disease. PLoS One (2011) 1.11
Association between Functional Small Airway Disease and FEV1 Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 1.07
Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene. Respir Res (2014) 1.06
Association between airway caliber changes with lung inflation and emphysema assessed by volumetric CT scan in subjects with COPD. Chest (2011) 1.03
Six-minute walk distance predictors, including CT scan measures, in the COPDGene cohort. Chest (2011) 1.03
Paired inspiratory-expiratory chest CT scans to assess for small airways disease in COPD. Respir Res (2013) 1.00
Family history is a risk factor for COPD. Chest (2011) 0.96
Induced sputum genes associated with spirometric and radiological disease severity in COPD ex-smokers. Thorax (2011) 0.95
Racial differences in CT phenotypes in COPD. COPD (2013) 0.95
Exome Sequencing Analysis in Severe, Early-Onset Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.92
Association between occupational exposure and lung function, respiratory symptoms, and high-resolution computed tomography imaging in COPDGene. Am J Respir Crit Care Med (2014) 0.89
Pulmonary function reduction in diabetes with and without chronic obstructive pulmonary disease. Diabetes Care (2013) 0.89
Clinical, physiologic, and radiographic factors contributing to development of hypoxemia in moderate to severe COPD: a cohort study. BMC Pulm Med (2016) 0.87
Analysis of Asthma-Chronic Obstructive Pulmonary Disease Overlap Syndrome Defined on the Basis of Bronchodilator Response and Degree of Emphysema. Ann Am Thorac Soc (2016) 0.87
Characterizing functional lung heterogeneity in COPD using reference equations for CT scan-measured lobar volumes. Chest (2013) 0.86
Risk factors for COPD exacerbations in inhaled medication users: the COPDGene study biannual longitudinal follow-up prospective cohort. BMC Pulm Med (2016) 0.86
Comparison between an alternative and the classic definition of chronic bronchitis in COPDGene. Ann Am Thorac Soc (2015) 0.85
Childhood pneumonia increases risk for chronic obstructive pulmonary disease: the COPDGene study. Respir Res (2015) 0.84
Impact of self-reported gastroesophageal reflux disease in subjects from COPDGene cohort. Respir Res (2014) 0.84
Impact of emphysema and airway wall thickness on quality of life in smoking-related COPD. Respir Med (2013) 0.83
Admixture mapping identifies a quantitative trait locus associated with FEV1/FVC in the COPDGene Study. Genet Epidemiol (2014) 0.82
Exome Array Analysis Identifies a Common Variant in IL27 Associated with Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2016) 0.81
Cardiovascular disease is associated with COPD severity and reduced functional status and quality of life. COPD (2014) 0.81
Persistent and Newly Developed Chronic Bronchitis Are Associated with Worse Outcomes in Chronic Obstructive Pulmonary Disease. Ann Am Thorac Soc (2016) 0.80
Obesity is Associated with Increased Morbidity in Moderate to Severe COPD. Chest (2016) 0.79
Effect of Emphysema Severity on the Apnea-Hypopnea Index in Smokers with Obstructive Sleep Apnea. Ann Am Thorac Soc (2016) 0.79
CT-derived Biomechanical Metrics Improve Agreement Between Spirometry and Emphysema. Acad Radiol (2016) 0.78
Phenotypic and genetic heterogeneity among subjects with mild airflow obstruction in COPDGene. Respir Med (2014) 0.78
Airway wall thickness is increased in COPD patients with bronchodilator responsiveness. Respir Res (2014) 0.78
Lung Mass in Smokers. Acad Radiol (2016) 0.77
Current Smoking Status Is Associated With Lower Quantitative CT Measures of Emphysema and Gas Trapping. J Thorac Imaging (2016) 0.77
Pneumothorax risk factors in smokers with and without chronic obstructive pulmonary disease. Ann Am Thorac Soc (2014) 0.77
Common Genetic Polymorphisms Influence Blood Biomarker Measurements in COPD. PLoS Genet (2016) 0.77
Childhood-onset asthma in smokers. association between CT measures of airway size, lung function, and chronic airflow obstruction. Ann Am Thorac Soc (2014) 0.77
Biomechanical CT metrics are associated with patient outcomes in COPD. Thorax (2017) 0.77
Genetic loci associated with chronic obstructive pulmonary disease overlap with loci for lung function and pulmonary fibrosis. Nat Genet (2017) 0.76
Multiplanar MDCT measurement of esophageal hiatus surface area: association with hiatal hernia and GERD. Surg Endosc (2015) 0.76
Sex-specific features of emphysema among current and former smokers with COPD. Eur Respir J (2015) 0.76
GDF-15 plasma levels in chronic obstructive pulmonary disease are associated with subclinical coronary artery disease. Respir Res (2017) 0.75
Acute Exacerbations and Lung Function Loss in Smokers With and Without COPD. Am J Respir Crit Care Med (2016) 0.75
Post-imaging pulmonary nodule mathematical prediction models: are they clinically relevant? Eur Radiol (2019) 0.75
Signs of Gas Trapping in Normal Lung Density Regions in Smokers. Am J Respir Crit Care Med (2017) 0.75
CT Measure of Lung At-risk and Lung Function Decline in Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med (2017) 0.75
Handgrip Strength in Chronic Obstructive Pulmonary Disease. Associations with Acute Exacerbations and Body Composition. Ann Am Thorac Soc (2017) 0.75
Ventricular Geometry From Non-contrast Non-ECG-gated CT Scans: An Imaging Marker of Cardiopulmonary Disease in Smokers. Acad Radiol (2017) 0.75
Lobar Emphysema Distribution Is Associated With 5-Year Radiological Disease Progression. Chest (2017) 0.75
Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. Chest (2017) 0.75
Genetic Association and Risk Scores in a COPD Meta-Analysis of 16,707 Subjects. Am J Respir Cell Mol Biol (2017) 0.75