Published in Oncotarget on February 02, 2016
Empirical verification of evolutionary theories of aging. Aging (Albany NY) (2016) 0.84
Discovery of plant extracts that greatly delay yeast chronological aging and have different effects on longevity-defining cellular processes. Oncotarget (2016) 0.77
Communications between Mitochondria, the Nucleus, Vacuoles, Peroxisomes, the Endoplasmic Reticulum, the Plasma Membrane, Lipid Droplets, and the Cytosol during Yeast Chronological Aging. Front Genet (2016) 0.75
Hallmarks of cancer: the next generation. Cell (2011) 140.01
Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 49.82
On the origin of cancer cells. Science (1956) 49.55
Observations on the carbohydrate metabolism of tumours. Biochem J (1929) 33.77
The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 18.87
Microenvironmental regulation of metastasis. Nat Rev Cancer (2008) 15.76
Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 15.44
The hallmarks of aging. Cell (2013) 14.29
Cancer cell metabolism: Warburg and beyond. Cell (2008) 11.80
Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat Rev Cancer (2007) 10.20
PI3K pathway alterations in cancer: variations on a theme. Oncogene (2008) 9.94
Metabolic reprogramming: a cancer hallmark even warburg did not anticipate. Cancer Cell (2012) 9.88
Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance. Cancer Cell (2006) 9.80
Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012. Cell Death Differ (2011) 9.44
Molecular mechanisms of necroptosis: an ordered cellular explosion. Nat Rev Mol Cell Biol (2010) 9.06
The chemical genomic portrait of yeast: uncovering a phenotype for all genes. Science (2008) 8.52
Brick by brick: metabolism and tumor cell growth. Curr Opin Genet Dev (2008) 7.87
THE METABOLISM OF TUMORS IN THE BODY. J Gen Physiol (1927) 7.64
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol (2011) 7.07
Four faces of cellular senescence. J Cell Biol (2011) 6.86
Autophagic cell death: the story of a misnomer. Nat Rev Mol Cell Biol (2008) 6.78
The emerging role of lysophosphatidic acid in cancer. Nat Rev Cancer (2003) 6.70
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 6.15
Targeting cancer metabolism: a therapeutic window opens. Nat Rev Drug Discov (2011) 5.79
Atg32 is a mitochondrial protein that confers selectivity during mitophagy. Dev Cell (2009) 5.77
Biologically active sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer (2004) 5.63
Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell (2010) 5.47
Links between metabolism and cancer. Genes Dev (2012) 5.27
Pyruvate kinase type M2 and its role in tumor growth and spreading. Semin Cancer Biol (2005) 5.25
Chemogenomic profiling: identifying the functional interactions of small molecules in yeast. Proc Natl Acad Sci U S A (2004) 5.10
Aging, cellular senescence, and cancer. Annu Rev Physiol (2012) 5.08
Induction of autophagy by spermidine promotes longevity. Nat Cell Biol (2009) 5.00
Discovering modes of action for therapeutic compounds using a genome-wide screen of yeast heterozygotes. Cell (2004) 4.91
Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov (2013) 4.72
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 4.09
Exploring the mode-of-action of bioactive compounds by chemical-genetic profiling in yeast. Cell (2006) 4.03
A kinetic study of glycolytic enzyme synthesis in yeast. J Biol Chem (1971) 3.99
Mitochondrial tumour suppressors: a genetic and biochemical update. Nat Rev Cancer (2005) 3.85
How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature (2012) 3.77
Pyruvate kinase type M2: a key regulator of the metabolic budget system in tumor cells. Int J Biochem Cell Biol (2010) 3.72
Saturated fatty acids induce endoplasmic reticulum stress and apoptosis independently of ceramide in liver cells. Am J Physiol Endocrinol Metab (2006) 3.71
Adipose triglyceride lipase contributes to cancer-associated cachexia. Science (2011) 3.70
Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death. J Lipid Res (2006) 3.64
Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis. Nat Med (2009) 3.43
Lipid metabolism in cancer. FEBS J (2012) 3.42
Regulation of stearoyl-CoA desaturases and role in metabolism. Prog Lipid Res (2004) 3.14
The machinery of macroautophagy. Cell Res (2013) 3.13
Increased lipogenesis in cancer cells: new players, novel targets. Curr Opin Clin Nutr Metab Care (2006) 3.09
Cancer cell metabolism: one hallmark, many faces. Cancer Discov (2012) 3.03
Investigating metformin for cancer prevention and treatment: the end of the beginning. Cancer Discov (2012) 3.02
FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling. Cell Metab (2012) 2.96
Cellular metabolism and disease: what do metabolic outliers teach us? Cell (2012) 2.90
Cellular fatty acid metabolism and cancer. Cell Metab (2013) 2.82
Hexokinase 2 is required for tumor initiation and maintenance and its systemic deletion is therapeutic in mouse models of cancer. Cancer Cell (2013) 2.55
The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proc Natl Acad Sci U S A (2009) 2.55
Mechanism of action of A-769662, a valuable tool for activation of AMP-activated protein kinase. J Biol Chem (2007) 2.54
Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology (2005) 2.47
Cdk1/Cdc28-dependent activation of the major triacylglycerol lipase Tgl4 in yeast links lipolysis to cell-cycle progression. Mol Cell (2009) 2.46
Fatty acid metabolism: target for metabolic syndrome. J Lipid Res (2008) 2.36
Apoptosis in yeast: triggers, pathways, subroutines. Cell Death Differ (2010) 2.34
Nutritional control of growth and development in yeast. Genetics (2012) 2.33
Discovery of drug-resistant and drug-sensitizing mutations in the oncogenic PI3K isoform p110 alpha. Cancer Cell (2008) 2.32
Metabolic targets for cancer therapy. Nat Rev Drug Discov (2013) 2.32
Isolation and characterization of OLE1, a gene affecting fatty acid desaturation from Saccharomyces cerevisiae. J Biol Chem (1989) 2.28
Role of prostaglandin E2-dependent angiogenic switch in cyclooxygenase 2-induced breast cancer progression. Proc Natl Acad Sci U S A (2003) 2.23
Aging and immortality: quasi-programmed senescence and its pharmacologic inhibition. Cell Cycle (2006) 2.23
Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis. Cancer Cell (2015) 2.21
A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol (2009) 2.16
VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium. Cancer Cell (2012) 2.14
Growth and aging: a common molecular mechanism. Aging (Albany NY) (2009) 2.13
Cell death by autophagy: facts and apparent artefacts. Cell Death Differ (2011) 2.06
M2 macrophages induced by prostaglandin E2 and IL-6 from cervical carcinoma are switched to activated M1 macrophages by CD4+ Th1 cells. J Immunol (2011) 2.02
Stearoyl-CoA desaturase-1: a novel key player in the mechanisms of cell proliferation, programmed cell death and transformation to cancer. Carcinogenesis (2010) 2.01
Fatty acid synthase as a potential therapeutic target in cancer. Future Oncol (2010) 2.00
Stearoyl-CoA desaturase 1 is a novel molecular therapeutic target for clear cell renal cell carcinoma. Clin Cancer Res (2013) 2.00
Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. Genetics (2012) 1.98
Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance. Oncotarget (2012) 1.96
Choosing between glycolysis and oxidative phosphorylation: a tumor's dilemma? Biochim Biophys Acta (2010) 1.94
Rocking cell metabolism: revised functions of the key glycolytic regulator PKM2 in cancer. Trends Biochem Sci (2012) 1.89
Yeast: an experimental organism for 21st Century biology. Genetics (2011) 1.88
Adipose tissue and adipocytes support tumorigenesis and metastasis. Biochim Biophys Acta (2013) 1.85
Fatty acid synthase expression defines distinct molecular signatures in prostate cancer. Mol Cancer Res (2003) 1.83
Autophagic cell death: Loch Ness monster or endangered species? Autophagy (2011) 1.82
Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells. Cancer Res (2007) 1.81
Highly selective inhibitors of monoacylglycerol lipase bearing a reactive group that is bioisosteric with endocannabinoid substrates. Chem Biol (2012) 1.79
Autophagic processes in yeast: mechanism, machinery and regulation. Genetics (2013) 1.78
Cancer cell dependence on unsaturated fatty acids implicates stearoyl-CoA desaturase as a target for cancer therapy. Mol Cancer Res (2011) 1.76
Peroxisomal beta-oxidation--a metabolic pathway with multiple functions. Biochim Biophys Acta (2006) 1.76
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes. Aging (Albany NY) (2010) 1.76
Human stearoyl-CoA desaturase: alternative transcripts generated from a single gene by usage of tandem polyadenylation sites. Biochem J (1999) 1.75
Yeast-like chronological senescence in mammalian cells: phenomenon, mechanism and pharmacological suppression. Aging (Albany NY) (2011) 1.74
Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains. Proc Natl Acad Sci U S A (2013) 1.73
Cyclooxygenases, prostanoids, and tumor progression. Cancer Metastasis Rev (2007) 1.72
Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis. Cancer Res (2012) 1.71
Ageing as a risk factor for disease. Curr Biol (2012) 1.71
Dysregulation of the mevalonate pathway promotes transformation. Proc Natl Acad Sci U S A (2010) 1.71
Metabolism and proliferation share common regulatory pathways in cancer cells. Oncogene (2010) 1.68
The Warburg and Crabtree effects: On the origin of cancer cell energy metabolism and of yeast glucose repression. Biochim Biophys Acta (2010) 1.68
Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6. Biochemistry (2005) 1.65
Overexpression of fatty acid synthase is an early and common event in the development of prostate cancer. Int J Cancer (2002) 1.65
Spatiotemporal dynamics of the ER-derived peroxisomal endomembrane system. Int Rev Cell Mol Biol (2009) 0.88
The Intricate Interplay between Mechanisms Underlying Aging and Cancer. Aging Dis (2014) 0.79
Cell-Nonautonomous Mechanisms Underlying Cellular and Organismal Aging. Int Rev Cell Mol Biol (2015) 0.77
Six plant extracts delay yeast chronological aging through different signaling pathways. Oncotarget (2016) 0.76
Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast. Oncotarget (2017) 0.76