Constitutive Reprogramming of Fibroblast Mitochondrial Metabolism in Pulmonary Hypertension.

PubWeight™: 0.79‹?›

🔗 View Article (PMID 26699943)

Published in Am J Respir Cell Mol Biol on July 01, 2016

Authors

Lydie Plecitá-Hlavatá1, Jan Tauber1, Min Li2, Hui Zhang2,3, Amanda R Flockton2, Soni Savai Pullamsetti4, Prakash Chelladurai4, Angelo D'Alessandro5, Karim C El Kasmi6, Petr Ježek1, Kurt R Stenmark2

Author Affiliations

1: 1 Department of Membrane Transport Biophysics, Institute of Physiology, Czech Academy of Sciences, Prague, Czech Republic.
2: 2 Developmental Lung Biology and Cardiovascular Pulmonary Research Laboratory, University of Colorado, Denver, Colorado.
3: 3 Department of Pediatrics, Shengjing Hospital of China Medical, University, Shenyang, China.
4: 4 Department of Lung Development and Remodeling, University of Giessen and Marburg Lung Center, Bad Nauheim, Germany; and.
5: Department of 5 Biochemistry and Molecular Genetics, and.
6: 6 Pediatric Gastroenterology, University of Colorado, Denver, Colorado.

Articles cited by this

Hallmarks of cancer: the next generation. Cell (2011) 140.01

HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 13.22

The redox state of free nicotinamide-adenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J (1967) 12.40

Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab (2005) 6.85

Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts. Nat Protoc (2007) 6.57

Metabolism of inflammation limited by AMPK and pseudo-starvation. Nature (2013) 3.76

Inflammation, growth factors, and pulmonary vascular remodeling. J Am Coll Cardiol (2009) 3.75

Hypoxia-dependent regulation of nonphagocytic NADPH oxidase subunit NOX4 in the pulmonary vasculature. Circ Res (2007) 3.28

The sites and topology of mitochondrial superoxide production. Exp Gerontol (2010) 2.91

Histone deacetylation inhibition in pulmonary hypertension: therapeutic potential of valproic acid and suberoylanilide hydroxamic acid. Circulation (2012) 2.54

The genetics and pathology of oxidative phosphorylation. Nat Rev Genet (2001) 2.48

Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol (1997) 2.47

Dichloroacetate prevents and reverses pulmonary hypertension by inducing pulmonary artery smooth muscle cell apoptosis. Circ Res (2004) 2.06

Relevant issues in the pathology and pathobiology of pulmonary hypertension. J Am Coll Cardiol (2013) 1.96

Hypoxia triggers subcellular compartmental redox signaling in vascular smooth muscle cells. Circ Res (2009) 1.92

Sustained hypoxia leads to the emergence of cells with enhanced growth, migratory, and promitogenic potentials within the distal pulmonary artery wall. Am J Physiol Lung Cell Mol Physiol (2009) 1.81

MicroRNA-124 controls the proliferative, migratory, and inflammatory phenotype of pulmonary vascular fibroblasts. Circ Res (2013) 1.80

Hypoxia inducible-factor1alpha regulates the metabolic shift of pulmonary hypertensive endothelial cells. Am J Pathol (2010) 1.79

Hypoxia exposure induces the emergence of fibroblasts lacking replication repressor signals of PKCzeta in the pulmonary artery adventitia. Cardiovasc Res (2008) 1.72

Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization. Cell Metab (2014) 1.65

Mitochondria: from cell death executioners to regulators of cell differentiation. Trends Cell Biol (2014) 1.53

Bone Morphogenetic Protein Receptor Type II Deficiency and Increased Inflammatory Cytokine Production. A Gateway to Pulmonary Arterial Hypertension. Am J Respir Crit Care Med (2015) 1.53

Fibroblasts as novel therapeutic targets in chronic inflammation. Br J Pharmacol (2007) 1.45

Targeting energetic metabolism: a new frontier in the pathogenesis and treatment of pulmonary hypertension. Am J Respir Crit Care Med (2011) 1.41

Emergence of fibroblasts with a proinflammatory epigenetically altered phenotype in severe hypoxic pulmonary hypertension. J Immunol (2011) 1.39

Gene transfer of extracellular superoxide dismutase ameliorates pulmonary hypertension in rats. Am J Respir Crit Care Med (2007) 1.33

The adventitia: essential regulator of vascular wall structure and function. Annu Rev Physiol (2012) 1.31

More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. Immunol Invest (2006) 1.21

Pathological mutations of the human NDUFS4 gene of the 18-kDa (AQDQ) subunit of complex I affect the expression of the protein and the assembly and function of the complex. J Biol Chem (2003) 1.16

The metabolic theory of pulmonary arterial hypertension. Circ Res (2014) 1.13

Adventitial fibroblasts induce a distinct proinflammatory/profibrotic macrophage phenotype in pulmonary hypertension. J Immunol (2014) 1.03

Metabolic dysfunction in pulmonary hypertension: the expanding relevance of the Warburg effect. Eur J Clin Invest (2013) 1.03

Role of arginase 1 from myeloid cells in th2-dominated lung inflammation. PLoS One (2013) 1.02

NADPH oxidase 4 is expressed in pulmonary artery adventitia and contributes to hypertensive vascular remodeling. Arterioscler Thromb Vasc Biol (2014) 0.98

Natural disease course and genotype-phenotype correlations in Complex I deficiency caused by nuclear gene defects: what we learned from 130 cases. J Inherit Metab Dis (2012) 0.97

Targeting the adventitial microenvironment in pulmonary hypertension: A potential approach to therapy that considers epigenetic change. Pulm Circ (2012) 0.94

N-acetylcysteine inhibits hypoxic pulmonary hypertension most effectively in the initial phase of chronic hypoxia. Life Sci (2005) 0.93

Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension. J Appl Physiol (1985) (2015) 0.91

Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling. Cardiovasc Res (2012) 0.91

Suppression of mitochondrial complex I influences cell metastatic properties. PLoS One (2013) 0.90

Mitochondrial dynamics in pulmonary arterial hypertension. J Mol Med (Berl) (2015) 0.89

Targeting mitochondrial reactive oxygen species to modulate hypoxia-induced pulmonary hypertension. Free Radic Biol Med (2015) 0.88

Complex I deficiency due to selective loss of Ndufs4 in the mouse heart results in severe hypertrophic cardiomyopathy. PLoS One (2014) 0.86

Mitochondrial Complex I superoxide production is attenuated by uncoupling. Int J Biochem Cell Biol (2008) 0.86

Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol (2012) 0.83

Pharmacological targeting of mitochondrial complex I deficiency: the cellular level and beyond. Mitochondrion (2011) 0.82

The role of non-hematopoietic stromal cells in the persistence of inflammation. Front Immunol (2013) 0.82

Activation of the cAMP cascade in human fibroblast cultures rescues the activity of oxidatively damaged complex I. Free Radic Biol Med (2011) 0.79