HIV Envelope Trimer Specific Immune Response Is Influenced by Different Adjuvant Formulations and Heterologous Prime-Boost.

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Published in PLoS One on January 04, 2016

Authors

Juliana de Souza Apostólico1, Silvia Beatriz Boscardin2, Márcio Massao Yamamoto2, Jethe Nunes de Oliveira-Filho1, Jorge Kalil3,4, Edecio Cunha-Neto3,4,5, Daniela Santoro Rosa1,4

Author Affiliations

1: Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo (UNIFESP/EPM), São Paulo, Brazil.
2: Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil.
3: Heart Institute (InCor), University of São Paulo-School of Medicine, São Paulo, Brazil.
4: Institute for Investigation in Immunology-INCT, São Paulo, Brazil.
5: Laboratory of Clinical Immunology and Allergy-LIM60, University of São Paulo- School of Medicine, São Paulo, Brazil.

Associated clinical trials:

Safety of and Immune Response to a Combination HIV Vaccine Regimen in HIV Uninfected Adults | NCT00073216

Safety of and Immune Response to a DNA HIV Vaccine Boosted With a Modified Vaccinia HIV Vaccine and Protein HIV Vaccine in Healthy Adults | NCT01418235

Safety, Tolerability, and Immunogenicity Study of Homologous Ad26 Mosaic Vector Vaccine Regimens or Heterologous Ad26 Mosaic and MVA Mosaic Vector Vaccine Regimens With Glycoprotein 140 (gp140) for Human Immunodeficiency Virus (HIV) Prevention | NCT02315703

Investigating Immunisation Strategies of DNA, MVA and CN54rgp140 Adjuvanted With GLA-AF to Maximise Antibody Responses (UKHVCSpoke003) | NCT01922284

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