Rho GTPase signaling promotes constitutive expression and release of TGF-β2 by human trabecular meshwork cells.

PubWeight™: 0.75‹?›

🔗 View Article (PMID 26743044)

Published in Exp Eye Res on December 30, 2015

Authors

Cynthia L Pervan1, Jonathan D Lautz2, Andrea L Blitzer3, Kelly A Langert4, Evan B Stubbs5

Author Affiliations

1: Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, USA; Department of Ophthalmology, Loyola University Chicago, Maywood, IL, USA. Electronic address: cynthia.pervan@va.gov.
2: Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, USA; Program in Neuroscience, Loyola University Chicago, Maywood, IL, USA.
3: Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, USA; Stritch School of Medicine, Loyola University Chicago, Maywood, IL, USA.
4: Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, USA.
5: Research Service, Department of Veterans Affairs, Edward Hines Jr. VA Hospital, Hines, IL, USA; Department of Ophthalmology, Loyola University Chicago, Maywood, IL, USA; Program in Neuroscience, Loyola University Chicago, Maywood, IL, USA.

Articles cited by this

The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol (2006) 25.47

The Rho family GTPases RhoA, Rac1, and CDC42Hs regulate transcriptional activation by SRF. Cell (1995) 8.20

Prevalence of open-angle glaucoma among adults in the United States. Arch Ophthalmol (2004) 5.44

miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42. Nat Struct Mol Biol (2008) 4.81

Aqueous humor in glaucomatous eyes contains an increased level of TGF-beta 2. Exp Eye Res (1994) 2.40

TGFbeta2-induced changes in human trabecular meshwork: implications for intraocular pressure. Invest Ophthalmol Vis Sci (2006) 2.02

Effects of TGF-beta2 in perfused human eyes. Invest Ophthalmol Vis Sci (2004) 2.00

Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma. Invest Ophthalmol Vis Sci (2007) 1.97

Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA. Genes Dev (2001) 1.94

Transforming growth factor-beta 2 levels in aqueous humor of glaucomatous eyes. Graefes Arch Clin Exp Ophthalmol (2001) 1.77

Transforming growth factor beta 2 levels in the aqueous humor in different types of glaucoma and the relation to filtering bleb development. Graefes Arch Clin Exp Ophthalmol (2001) 1.62

Adenoviral gene transfer of active human transforming growth factor-{beta}2 elevates intraocular pressure and reduces outflow facility in rodent eyes. Invest Ophthalmol Vis Sci (2009) 1.56

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway. Genes Dev (2001) 1.41

Immunolocalization of TGF-beta 1, TGF-beta 2, and TGF-beta 3 in the anterior segment of the human eye. Invest Ophthalmol Vis Sci (1993) 1.40

Induction of tissue transglutaminase in the trabecular meshwork by TGF-beta1 and TGF-beta2. Invest Ophthalmol Vis Sci (2000) 1.37

The aqueous levels of TGF-beta2 in patients with glaucoma. Int Ophthalmol (2004) 1.34

Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery. Invest Ophthalmol Vis Sci (2003) 1.33

Higher concentration of transforming growth factor-beta in aqueous humor of glaucomatous eyes and diabetic eyes. Jpn J Ophthalmol (2002) 1.32

Bone morphogenetic protein-7 is an antagonist of transforming growth factor-beta2 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2007) 1.26

Mechanistic basis of Rho GTPase-induced extracellular matrix synthesis in trabecular meshwork cells. Am J Physiol Cell Physiol (2009) 1.24

The effect of TGF-beta2 on human trabecular meshwork extracellular proteolytic system. Exp Eye Res (2003) 1.20

A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy. Ophthalmology (2007) 1.18

Novel antisense oligonucleotides targeting TGF-beta inhibit in vivo scarring and improve surgical outcome. Gene Ther (2003) 1.17

Gene expression profiling of TGFbeta2- and/or BMP7-treated trabecular meshwork cells: Identification of Smad7 as a critical inhibitor of TGF-beta2 signaling. Exp Eye Res (2009) 1.14

Concentration of transforming growth factor beta2 in aqueous humor. Ophthalmic Res (2004) 1.13

Ultrastructural and biochemical evaluation of the porcine anterior chamber perfusion model. Invest Ophthalmol Vis Sci (2006) 1.12

Cross-talk between miR-29 and transforming growth factor-betas in trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 1.11

Ocular gene transfer of active TGF-beta induces changes in anterior segment morphology and elevated IOP in rats. Invest Ophthalmol Vis Sci (2009) 1.10

Multiple forms of TGF-beta: distinct promoters and differential expression. Ciba Found Symp (1991) 1.07

Differential effects of ADAMTS-1, -4, and -5 in the trabecular meshwork. Invest Ophthalmol Vis Sci (2009) 1.06

Effects of cholesterol-lowering statins on the aqueous humor outflow pathway. Invest Ophthalmol Vis Sci (2005) 1.03

Transcriptional regulation of the transforming growth factor-beta2 promoter by cAMP-responsive element-binding protein (CREB) and activating transcription factor-1 (ATF-1) is modulated by protein kinases and the coactivators p300 and CREB-binding protein. J Biol Chem (1999) 0.99

Transforming growth factor-beta2 utilizes the canonical Smad-signaling pathway to regulate tissue transglutaminase expression in human trabecular meshwork cells. Exp Eye Res (2011) 0.99

Elasticity-dependent modulation of TGF-β responses in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 0.98

Transforming growth factor-beta levels in human aqueous humor of glaucomatous, diabetic and uveitic eyes. Korean J Ophthalmol (2006) 0.98

Cochlin expression in anterior segment organ culture models after TGFbeta2 treatment. Invest Ophthalmol Vis Sci (2008) 0.96

Regulation of plasticity and fibrogenic activity of trabecular meshwork cells by Rho GTPase signaling. J Cell Physiol (2014) 0.96

miR-29 promotes murine osteoclastogenesis by regulating osteoclast commitment and migration. J Biol Chem (2013) 0.92

Trabecular cells express the TGF-beta 2 gene and secrete the cytokine. Exp Eye Res (1994) 0.91

SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Invest Ophthalmol Vis Sci (2008) 0.89

TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells. J Hepatol (2010) 0.88

Smad3 is necessary for transforming growth factor-beta2 induced ocular hypertension in mice. Exp Eye Res (2013) 0.85

Cdc42 GTPases facilitate TNF-α-mediated secretion of CCL2 from peripheral nerve microvascular endoneurial endothelial cells. J Peripher Nerv Syst (2013) 0.85

Suppression of transforming growth factor-β effects in rabbit subconjunctival fibroblasts by activin receptor-like kinase 5 inhibitor. Mol Vis (2010) 0.84

Immunolocalization of TGF-beta1, -beta2, and -beta3, and TGF-beta receptors in human lens capsules with lens implants. Graefes Arch Clin Exp Ophthalmol (2000) 0.84

Increased RhoA and RhoB protein accumulation in cultured human trabecular meshwork cells by lovastatin. Invest Ophthalmol Vis Sci (2009) 0.83

Effects of pharmacologic inhibition of protein geranylgeranyltransferase type I on aqueous humor outflow through the trabecular meshwork. Invest Ophthalmol Vis Sci (2008) 0.82

Geranylgeranylation facilitates proteasomal degradation of rho G-proteins in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2011) 0.82

Transforming growth factor-β2 induces synthesis and secretion of endothelin-1 in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2012) 0.82

Decorin Reduces Intraocular Pressure and Retinal Ganglion Cell Loss in Rodents Through Fibrolysis of the Scarred Trabecular Meshwork. Invest Ophthalmol Vis Sci (2015) 0.81

Pharmacological regulation of SPARC by lovastatin in human trabecular meshwork cells. Invest Ophthalmol Vis Sci (2014) 0.81

Prenylation of Rho G-proteins: a novel mechanism regulating gene expression and protein stability in human trabecular meshwork cells. Mol Neurobiol (2012) 0.81

TGF-β2-mediated ocular hypertension is attenuated in SPARC-null mice. Invest Ophthalmol Vis Sci (2014) 0.78

Novel role of Cdc42 and RalA GTPases in TNF-α mediated secretion of CCL2. Small GTPases (2014) 0.77

All-Trans Retinoic Acid Induces TGF-β2 in Intestinal Epithelial Cells via RhoA- and p38α MAPK-Mediated Activation of the Transcription Factor ATF2. PLoS One (2015) 0.76