Published in J Biol Chem on December 15, 1989
Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone. Mol Cell Biol (1992) 2.80
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Exploring the interaction between the protein kinase A catalytic subunit and caveolin-1 scaffolding domain with shotgun scanning, oligomer complementation, NMR, and docking. Protein Sci (2006) 0.85
Catalytic subunits of Aplysia neuronal cAMP-dependent protein kinase with two different N termini. Proc Natl Acad Sci U S A (1992) 0.83
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Mapping the Hydrogen Bond Networks in the Catalytic Subunit of Protein Kinase A Using H/D Fractionation Factors. Biochemistry (2015) 0.77
Expression of Chinese hamster cAMP-dependent protein kinase in Escherichia coli results in growth inhibition of bacterial cells: a model system for the rapid screening of mutant type I regulatory subunits. Proc Natl Acad Sci U S A (1993) 0.77
A new autoinhibited kinase conformation reveals a salt-bridge switch in kinase activation. Sci Rep (2016) 0.75
Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 13.85
Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Science (1991) 9.99
Identification of a signal for rapid export of proteins from the nucleus. Cell (1995) 9.92
Fluorescence ratio imaging of cyclic AMP in single cells. Nature (1991) 4.45
Phosphorylation sites in enolase and lactate dehydrogenase utilized by tyrosine protein kinases in vivo and in vitro. J Biol Chem (1984) 4.20
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites. Nature (1984) 3.91
Crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MgATP and peptide inhibitor. Biochemistry (1993) 3.88
Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proc Natl Acad Sci U S A (2001) 3.77
Phosphorylation and inactivation of BAD by mitochondria-anchored protein kinase A. Mol Cell (1999) 3.46
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Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains. Science (1995) 3.18
A protein that activates expression of a multidrug efflux transporter upon binding the transporter substrates. J Biol Chem (1994) 3.08
A visual screen of a GFP-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol (1999) 2.69
2.2 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with MnATP and a peptide inhibitor. Acta Crystallogr D Biol Crystallogr (1993) 2.66
cAMP-dependent protein kinase: crystallographic insights into substrate recognition and phosphotransfer. Protein Sci (1994) 2.62
Protein N-myristoylation in Escherichia coli: reconstitution of a eukaryotic protein modification in bacteria. Proc Natl Acad Sci U S A (1990) 2.61
Affinity labeling of cAMP-dependent protein kinase with p-fluorosulfonylbenzoyl adenosine. Covalent modification of lysine 71. J Biol Chem (1981) 2.48
Crystal structures of the myristylated catalytic subunit of cAMP-dependent protein kinase reveal open and closed conformations. Protein Sci (1993) 2.44
A genetically encoded, fluorescent indicator for cyclic AMP in living cells. Nat Cell Biol (2000) 2.34
Primary structure of Torpedo californica acetylcholinesterase deduced from its cDNA sequence. Nature (1986) 2.32
Two highly similar multidrug transporters of Bacillus subtilis whose expression is differentially regulated. J Bacteriol (1995) 2.26
Aneuploid colon cancer cells have a robust spindle checkpoint. EMBO Rep (2001) 2.12
Identification of a novel protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J Biol Chem (1997) 2.10
Phosphorylation and activation of cAMP-dependent protein kinase by phosphoinositide-dependent protein kinase. Proc Natl Acad Sci U S A (1998) 2.09
Structural adaptations of lactate dehydrogenase isozymes. Proc Natl Acad Sci U S A (1977) 1.88
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The protein kinase resource. Trends Biochem Sci (1997) 1.85
Climate change and the integrity of science. Science (2010) 1.80
D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc Natl Acad Sci U S A (1997) 1.79
Movement of the free catalytic subunit of cAMP-dependent protein kinase into and out of the nucleus can be explained by diffusion. Mol Biol Cell (1993) 1.71
Energetic limits of phosphotransfer in the catalytic subunit of cAMP-dependent protein kinase as measured by viscosity experiments. Biochemistry (1992) 1.64
Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit. Structure (2001) 1.59
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates. J Biol Chem (1990) 1.57
Role of the glycine triad in the ATP-binding site of cAMP-dependent protein kinase. J Biol Chem (1997) 1.55
Phosphorylation modulates catalytic function and regulation in the cAMP-dependent protein kinase. Biochemistry (1995) 1.55
Phosphorylation of histones 1 and 3 and nonhistone high mobility group 14 by an endogenous kinase in HeLa metaphase chromosomes. J Biol Chem (1982) 1.54
Structural features that specify tyrosine kinase activity deduced from homology modeling of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1993) 1.53
Expression of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli: multiple isozymes reflect different phosphorylation states. Protein Eng (1993) 1.52
A binary complex of the catalytic subunit of cAMP-dependent protein kinase and adenosine further defines conformational flexibility. Structure (1997) 1.51
Crystal structure of a polyhistidine-tagged recombinant catalytic subunit of cAMP-dependent protein kinase complexed with the peptide inhibitor PKI(5-24) and adenosine. Biochemistry (1997) 1.50
Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry (1996) 1.48
Domain movements in protein kinases. Curr Opin Struct Biol (1994) 1.47
NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J Cell Biol (1999) 1.46
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal. J Biol Chem (1994) 1.43
N-myristylation of the catalytic subunit of cAMP-dependent protein kinase conveys structural stability. J Biol Chem (1993) 1.42
Profile of the disulfide bonds in acetylcholinesterase. J Biol Chem (1986) 1.42
Ribitol dehydrogenase from Klebsiella aerogenes. Purification and subunit structure. Biochem J (1974) 1.39
Serum protein electrophoresis in 147 dogs. Vet Rec (2011) 1.38
Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. J Biol Chem (1992) 1.37
The catalytic subunit of cAMP-dependent protein kinase: prototype for an extended network of communication. Prog Biophys Mol Biol (1999) 1.36
Structural comparisons of cAMP-dependent protein kinases I and II from porcine skeletal muscle. J Biol Chem (1979) 1.36
Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit. J Biol Chem (1998) 1.34
Physiological inhibitors of the catalytic subunit of cAMP-dependent protein kinase: effect of MgATP on protein-protein interactions. Biochemistry (1993) 1.33
600 ps molecular dynamics reveals stable substructures and flexible hinge points in cAMP dependent protein kinase. Biopolymers (1999) 1.32
Structural basis of the intrasteric regulation of myosin light chain kinases. Science (1992) 1.31
Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29
Identification of a partially rate-determining step in the catalytic mechanism of cAMP-dependent protein kinase: a transient kinetic study using stopped-flow fluorescence spectroscopy. Biochemistry (1997) 1.27
Phosphorylation of peptide substrates for the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1993) 1.27
Signal transduction through the cAMP-dependent protein kinase. Mol Cell Biochem (1993) 1.27
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase in Escherichia coli. Protein Eng (1997) 1.26
Dynamics of the distribution of cyclic AMP-dependent protein kinase in living cells. Proc Natl Acad Sci U S A (1990) 1.26
Identification of phosphorylation sites in the recombinant catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1993) 1.26
Structure of the mammalian catalytic subunit of cAMP-dependent protein kinase and an inhibitor peptide displays an open conformation. Acta Crystallogr D Biol Crystallogr (1993) 1.24
Mitogenic signaling by Ret/ptc2 requires association with enigma via a LIM domain. J Biol Chem (1996) 1.23
Serine-53 at the tip of the glycine-rich loop of cAMP-dependent protein kinase: role in catalysis, P-site specificity, and interaction with inhibitors. Biochemistry (2000) 1.23
Thermostable inhibitor of cAMP-dependent protein kinase enhances the rate of export of the kinase catalytic subunit from the nucleus. J Biol Chem (1994) 1.22
Correlation of the cAMP binding domain with a site of autophosphorylation on the regulatory subunit of cAMP-dependent protein kinase II from porcine skeletal muscle. J Biol Chem (1979) 1.21
Divalent metal ions influence catalysis and active-site accessibility in the cAMP-dependent protein kinase. Protein Sci (1993) 1.19
Identification of aspartate-184 as an essential residue in the catalytic subunit of cAMP-dependent protein kinase. Biochemistry (1988) 1.19
Kinetic analyses of mutations in the glycine-rich loop of cAMP-dependent protein kinase. Biochemistry (1998) 1.19
Importance of the A-helix of the catalytic subunit of cAMP-dependent protein kinase for stability and for orienting subdomains at the cleft interface. Protein Sci (1997) 1.19
A point mutation abolishes binding of cAMP to site A in the regulatory subunit of cAMP-dependent protein kinase. J Biol Chem (1988) 1.18
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc Natl Acad Sci U S A (1999) 1.18
Conserved water molecules contribute to the extensive network of interactions at the active site of protein kinase A. Proc Natl Acad Sci U S A (1998) 1.18
Affinity labeling of the nucleotide binding site of the catalytic subunit of cAMP-dependent protein kinase using p-fluorosulfonyl-[14C]benzoyl 5'-adenosine. Identification of a modified lysine residue. J Biol Chem (1979) 1.15
Relationships between structural domains and function in the regulatory subunit of cAMP-dependent protein kinases I and II from porcine skeletal muscle. J Biol Chem (1979) 1.14
DdPK3, which plays essential roles during Dictyostelium development, encodes the catalytic subunit of cAMP-dependent protein kinase. Proc Natl Acad Sci U S A (1992) 1.13
Cowpea mosaic virus: from the presentation of antigenic peptides to the display of active biomaterials. Intervirology (2002) 1.12
Differential binding of cAMP-dependent protein kinase regulatory subunit isoforms Ialpha and IIbeta to the catalytic subunit. J Biol Chem (2000) 1.11
Specificity of LIM domain interactions with receptor tyrosine kinases. J Biol Chem (1996) 1.11
Divergence in primary structure between the molecular forms of acetylcholinesterase. J Biol Chem (1988) 1.10
Predicted structures of cAMP binding domains of type I and II regulatory subunits of cAMP-dependent protein kinase. Biochemistry (1987) 1.10
Prokaryotic expression of catalytic subunit of adenosine cyclic monophosphate-dependent protein kinase. Methods Enzymol (1991) 1.10
A conserved helix motif complements the protein kinase core. Proc Natl Acad Sci U S A (1993) 1.10
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Cloning and mitochondrial localization of full-length D-AKAP2, a protein kinase A anchoring protein. Proc Natl Acad Sci U S A (2001) 1.08
A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Mol Cell Biol (1993) 1.08
Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. Biochemistry (1994) 1.07
Isoform-specific differences between the type Ialpha and IIalpha cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR. J Biol Chem (2000) 1.07
Crystal structure of the potent natural product inhibitor balanol in complex with the catalytic subunit of cAMP-dependent protein kinase. Biochemistry (1999) 1.06
Interaction of the regulatory and catalytic subunits of cAMP-dependent protein kinase. Electrostatic sites on the type Ialpha regulatory subunit. J Biol Chem (1997) 1.05
2.0 A refined crystal structure of the catalytic subunit of cAMP-dependent protein kinase complexed with a peptide inhibitor and detergent. Acta Crystallogr D Biol Crystallogr (1993) 1.05
The structural domains of cAMP-dependent protein kinase I. Characterization of two sites of proteolytic cleavage and homologies to cAMP-dependent protein kinase II. J Biol Chem (1980) 1.05
Differential labeling of the catalytic subunit of cAMP-dependent protein kinase with acetic anhydride: substrate-induced conformational changes. Biochemistry (1989) 1.05
Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates. J Biol Chem (1982) 1.04
2H NMR studies of a myristoylated peptide in neutral and acidic phospholipid bicelles. Biochemistry (1998) 1.03
Autophosphorylation of the catalytic subunit of cAMP-dependent protein kinase. J Biol Chem (1992) 1.01
Consequences of cAMP-binding site mutations on the structural stability of the type I regulatory subunit of cAMP-dependent protein kinase. Biochemistry (2000) 1.00
Backbone flexibility of five sites on the catalytic subunit of cAMP-dependent protein kinase in the open and closed conformations. Biochemistry (1998) 0.99