Published in Nature on June 15, 1978
13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats. Proc Natl Acad Sci U S A (1979) 2.19
Matrix alkalinization: a novel mitochondrial signal for sustained pancreatic beta-cell activation. EMBO J (2009) 1.85
Activity of phosphorylase in total global ischaemia in the rat heart. A phosphorus-31 nuclear-magnetic-resonance study. Biochem J (1981) 1.65
Rapid ATP assays in perfused mouse liver by 31P NMR. Proc Natl Acad Sci U S A (1979) 1.36
31P NMR reveals increased intracellular pH after fertilization in Xenopus eggs. Proc Natl Acad Sci U S A (1981) 1.18
Bicarbonate-dependent and -independent intracellular pH regulatory mechanisms in rat hepatocytes. Evidence for Na+-HCO3- cotransport. J Clin Invest (1989) 1.05
Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets. J Biol Chem (2009) 1.03
Adenine nucleotide storage and secretion in platelets as studied by 31P nuclear magnetic resonance. Proc Natl Acad Sci U S A (1979) 0.98
The role of intrarenal pH in regulation of ammoniagenesis: [31P]NMR studies of the isolated perfused rat kidney. J Physiol (1981) 0.89
The cytosolic concentration of phosphate determines the maximal rate of glycogenolysis in perfused rat liver. Biochem J (1990) 0.81
New advances in MR-compatible bioartificial liver. NMR Biomed (2011) 0.77
Effect of phenylephrine on the compartmentation of inorganic phosphate in perfused rat liver during gluconeogenesis and urea synthesis: a 31P-n.m.r.-spectroscopic study. Biochem J (1994) 0.77
Lactic dehydrogenase isozymes, 31P magnetic resonance spectroscopy, and in vitro antimitochondrial tumor toxicity with gossypol and rhodamine-123. J Clin Invest (1987) 0.75
Pertussis Vaccine Prepared with Phase-I Cultures Grown in Fluid Medium. Am J Public Health Nations Health (1946) 17.04
Growth of human hepatoma cells lines with differentiated functions in chemically defined medium. Cancer Res (1982) 11.72
Oxygenation-sensitive contrast in magnetic resonance image of rodent brain at high magnetic fields. Magn Reson Med (1990) 9.62
The measurement of membrane potential and deltapH in cells, organelles, and vesicles. Methods Enzymol (1979) 9.41
The effect of adrenalin on the gaseous metabolism of the isolated mammalian heart. J Physiol (1914) 8.89
Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N Engl J Med (1990) 7.13
Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases. Nature (2000) 6.70
Optical trapping and manipulation of single cells using infrared laser beams. Nature (1988) 6.04
Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest (1999) 5.30
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The proton electrochemical gradient in Escherichia coli cells. Eur J Biochem (1976) 5.13
NMR chemical shift imaging in three dimensions. Proc Natl Acad Sci U S A (1982) 4.95
Systematic gain-of-function genetics in Drosophila. Development (1998) 4.71
Catechol-O-methyltransferase-deficient mice exhibit sexually dimorphic changes in catecholamine levels and behavior. Proc Natl Acad Sci U S A (1998) 3.99
Endocrine-disrupting chemicals and public health protection: a statement of principles from The Endocrine Society. Endocrinology (2012) 3.98
A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner. EMBO J (1994) 3.88
Two distinct mechanisms for long-range patterning by Decapentaplegic in the Drosophila wing. Nature (1996) 3.81
Energy on demand. Science (1999) 3.80
The nomenclature of cell death: recommendations of an ad hoc Committee of the Society of Toxicologic Pathologists. Toxicol Pathol (1999) 3.73
Port site metastases after laparoscopic colorectal surgery for cure of malignancy. Br J Surg (1995) 3.64
Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study. J Clin Invest (1992) 3.55
Electrophysiological breakthroughs from the left atrium to the pulmonary veins. Circulation (2000) 3.43
The molecular mechanism of thermal unfolding of Escherichia coli formylmethionine transfer RNA. J Mol Biol (1974) 3.25
Developmental regulation of Dictyostelium discoideum actin gene fusions carried on low-copy and high-copy transformation vectors. Mol Cell Biol (1986) 3.20
Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activity. Proc Natl Acad Sci U S A (1998) 3.17
Cellular applications of 31P and 13C nuclear magnetic resonance. Science (1979) 3.14
Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell (2000) 3.10
Immunofluorescent detection of antibody to lymphocytic choriomeningitis virus in man. J Immunol (1966) 2.98
Determination of pH in chloroplasts. I. Distribution of ( 14 C) methylamine. Eur J Biochem (1972) 2.97
Quantitation of hepatic glycogenolysis and gluconeogenesis in fasting humans with 13C NMR. Science (1991) 2.92
Dpp gradient formation in the Drosophila wing imaginal disc. Cell (2000) 2.91
Wingless gradient formation in the Drosophila wing. Curr Biol (2000) 2.83
Determination of the rate of the glutamate/glutamine cycle in the human brain by in vivo 13C NMR. Proc Natl Acad Sci U S A (1999) 2.76
The measurement of transmembrane electrochemical proton gradients. J Bioenerg (1975) 2.74
High resolution 31P nuclear magnetic resonance studies of intact yeast cells. Proc Natl Acad Sci U S A (1975) 2.72
Phosphorus-31 nuclear magnetic resonance studies of wild-type and glycolytic pathway mutants of Saccharomyces cerevisiae. Biochemistry (1979) 2.67
Atovaquone, a broad spectrum antiparasitic drug, collapses mitochondrial membrane potential in a malarial parasite. J Biol Chem (1997) 2.67
High-resolution 31P nuclear magnetic resonance studies of metabolism in aerobic Escherichia coli cells. Proc Natl Acad Sci U S A (1977) 2.58
Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development (1997) 2.55
31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate. Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest (1992) 2.52
Determination of pH in chloroplasts. 2. Fluorescent amines as a probe for the determination of pH in chloroplasts. Eur J Biochem (1972) 2.45
Spatially localized 1H NMR spectra of metabolites in the human brain. Proc Natl Acad Sci U S A (1988) 2.44
An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease. Nature (1997) 2.42
Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol (1996) 2.42
High-resolution 1H nuclear magnetic resonance study of cerebral hypoxia in vivo. Proc Natl Acad Sci U S A (1983) 2.40
Mortality and mental health: evidence from the Midtown Manhattan Restudy. Soc Sci Med (1977) 2.36
Serrate signals through Notch to establish a Wingless-dependent organizer at the dorsal/ventral compartment boundary of the Drosophila wing. Development (1995) 2.36
Cell interaction between compartments establishes the proximal-distal axis of Drosophila legs. Nature (1994) 2.33
apterous, a gene required for imaginal disc development in Drosophila encodes a member of the LIM family of developmental regulatory proteins. Genes Dev (1992) 2.33
Color Doppler imaging of the eye and orbit. Technique and normal vascular anatomy. Arch Ophthalmol (1991) 2.31
Sequence of the intron/exon junctions of the coding region of the human androgen receptor gene and identification of a point mutation in a family with complete androgen insensitivity. Proc Natl Acad Sci U S A (1989) 2.28
Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons. J Biol Chem (1999) 2.27
The absence of "heme-heme" interactions in hemoglobin. Science (1969) 2.26
Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of non-insulin-dependent diabetes mellitus. Proc Natl Acad Sci U S A (1995) 2.25
Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing. Cell (1998) 2.25
Phosphorus nuclear magnetic resonance of fast- and slow-twitch muscle. Am J Physiol (1985) 2.21
Retracted A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA. EMBO J (2001) 2.21
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13C NMR studies of gluconeogenesis in rat liver cells: utilization of labeled glycerol by cells from euthyroid and hyperthyroid rats. Proc Natl Acad Sci U S A (1979) 2.19
Advanced protein glycosylation induces transendothelial human monocyte chemotaxis and secretion of platelet-derived growth factor: role in vascular disease of diabetes and aging. Proc Natl Acad Sci U S A (1990) 2.18
Phosphorus-31 nuclear magnetic resonance studies of the effect of oxygen upon glycolysis in yeast. Biochemistry (1981) 2.17
Membrane potential and surface potential in mitochondria: uptake and binding of lipophilic cations. J Membr Biol (1984) 2.17
Imaging at high magnetic fields: initial experiences at 4 T. Magn Reson Q (1993) 2.14
In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cycling. Proc Natl Acad Sci U S A (1997) 2.12
Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia. EMBO J (1994) 2.12
An estimation of the light-induced electrochemical potential difference of protons across the membrane of Halobacterium halobium. Biochim Biophys Acta (1976) 2.11
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol (2001) 2.11
In vitro antimycobacterial activities of newly synthesized benzoxazinorifamycins. Antimicrob Agents Chemother (1991) 2.08
Prophylaxis with carbon-adsorbed mitomycin against peritoneal recurrence of gastric cancer. Lancet (1992) 2.07
Cbfa1 isoforms exert functional differences in osteoblast differentiation. J Biol Chem (1999) 2.06
Determination of relative CMRO2 from CBF and BOLD changes: significant increase of oxygen consumption rate during visual stimulation. Magn Reson Med (1999) 2.06
Dose comparison trial of sustained-release fampridine in multiple sclerosis. Neurology (2008) 2.04
Long-term feeding of sodium saccharin to nonhuman primates: implications for urinary tract cancer. J Natl Cancer Inst (1998) 2.04
The fetal larynx and pharynx: structure and development on two- and three-dimensional ultrasound. Ultrasound Obstet Gynecol (2013) 2.03
Simultaneous determination of the rates of the TCA cycle, glucose utilization, alpha-ketoglutarate/glutamate exchange, and glutamine synthesis in human brain by NMR. J Cereb Blood Flow Metab (1995) 1.98
High resolution nuclear magnetic resonance studies of hydrogen bonded protons of tRNA in water. Nature (1971) 1.97
31P nuclear magnetic resonance studies of Ehrlich ascites tumor cells. Proc Natl Acad Sci U S A (1977) 1.97
The nature of spatiotemporal changes in cerebral hemodynamics as manifested in functional magnetic resonance imaging. Magn Reson Med (1997) 1.94
Experience in Treatment of War Burns. Br Med J (1940) 1.93
Dynamic mapping of the human visual cortex by high-speed magnetic resonance imaging. Proc Natl Acad Sci U S A (1992) 1.92
31P nuclear magnetic resonance studies of bioenergetics and glycolysis in anaerobic Escherichia coli cells. Proc Natl Acad Sci U S A (1978) 1.92
Homeotic genes of the Bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell (1992) 1.91